Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC34410 N-desmethyl Netupitant D6 N-desmethylNetupitantD6是N-desmethylNetupitant的氘代化合物标准品。
GC34409 Netupitant N-oxide D6 NetupitantN-oxideD6是NetupitantN-oxide的氘代化合物标准品。
GC34408 Monohydroxy Netupitant D6 MonohydroxyNetupitantD6是MonohydroxyNetupitant的氘代化合物标准品。
GC34373 Dabigatran D4 hydrochloride (BIBR-953 D4 hydrochloride) DabigatranD4盐酸盐是Dabigatran氘代化合物标准品。
GC34358 Leu-AMS R enantiomer Leu-AMSRenantiomer是Leu-AMS的R对映体。Leu-AMS是亮氨酰-tRNA合成酶(LRS)的有效抑制剂并抑制细菌的生长。
GC34331 Gln-AMS TFA Gln-AMS(TFA)是Ia类型的氨酰基-tRNA合成酶(AARS)抑制剂。Gln-AMS抑制谷氨酰胺酰-tRNA合成酶的Ki值为1.32µM。
GC34324 ZK824859 hydrochloride ZK824859hydrochloride是一种口服有效的选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂，用于人uPA，tPA和纤溶酶，IC50分别为79nM，1580nM和1330nM。
GC34287 AZ7550 hydrochloride An active metabolite of AZ 9291
GC34255 TP508 TP508是由23个氨基酸残基构成的多肽，它代表了人凝血素的第508-530位氨基酸序列，被认为是高亲和性受体与凝血素的结合域。
GC34193 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid)
对甲氧基苯乙酸,4-Methoxyphenylacetic acid
2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue.
GC34181 Tauroursodeoxycholate (TUDCA)
牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906
牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。
GC34179 2-Methoxybenzoic acid (NSC 3778)
邻甲氧基苯甲酸,NSC 3778; O-Methylsalicylic acid; Salicylic acid methyl ether
2-Methoxybenzoic acid (o-Anisic acid) is a flavouring agent.
GC34134 Glycocholic acid
甘氨胆酸
Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。
GC34123 Deoxycytidine triphosphate (dCTP)
脱氧胞苷三磷酸; dCTP; 2′-Deoxycytidine-5′-triphosphate
脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。
GC34113 N-(5-Aminopentyl)acetamide (Monoacetylcadaverine)
N-(5-氨基戊基)乙酰胺,Monoacetylcadaverine
N-(5-Aminopentyl)acetamide (Monoacetylcadaverine, N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound.
GC34092 Glycochenodeoxycholic acid (Chenodeoxycholylglycine)
甘氨鹅脱氧胆酸; Chenodeoxycholylglycine
A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications
GC34052 Fosfructose (Diphosphofructose)
二磷酸果糖; Diphosphofructose; Esafosfan; FDP
Fosfructose (Diphosphofructose) (Diphosphofructose;Esafosfan;FDP) 是一种具有细胞保护作用的天然磷酸糖，可用于治疗心血管缺血、镰状细胞性贫血和哮喘。
GC34040 Fosfructose trisodium (Diphosphofructose (trisodium))
D-果糖-1,6-二磷酸三钠盐,Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium
D-Fructose-1,6-diphosphate trisodium salt octahydrate (FBP trisodium salt octahydrate), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway.
GC34032 Napsagatran hydrate (Ro 46-6240 hydrate)
奈沙加群,Ro 46-6240 hydrate; Ro 46-6240/010 hydrate
Napsagatran hydrate (Ro 46-6240 hydrate) 是一种新型的特异性凝血酶抑制剂。
GC34027 N-Acetylprocainamide (Acecainide)
N-乙酰普鲁卡因胺; Acecainide; NAPA
N-Acetylprocainamide (Accecainide) 是一种 III 类抗心律失常药，可阻断 K+ 通道。
GC34021 Vitamin K4 (acetomenaphthone)
维生素K4; acetomenaphthone
A synthetic form of vitamin K
GC34019 Omapatrilat (BMS-186716)
BMS-186716
An ACE and NEP inhibitor
GC34016 11beta-Hydroxyprogesterone (11β-Hydroxyprogesterone)
11β-羟孕酮; 11β-Hydroxyprogesterone
A metabolite of progesterone
GC34011 FX-11 (LDHA Inhibitor FX11)
LDHA Inhibitor FX11
FX-11（LDHA 抑制剂 FX11）被发现是一种有效的竞争性人 LDH-A 的 NADH 结合口袋抑制剂。
GC33995 DL-3-Phenyllactic acid
DL-Β-苯乳酸
DL-3-Phenyllacticacid是一种广谱抗菌化合物。
GC33991 Hydroxyphenyllactic acid
3-(4-羟基苯基)乳酸
Hydroxyphenyllacticacid是一种抗真菌的代谢物。
GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein)
4',7-二甲氧基异黄酮; Dimethoxydaidzein
4',7-Dimethoxyisoflavone, isolated from the leaves of Albizzia lebbeck, shows antifungal activity in vitro.
GC33968 DPC-681 (DPH-153893)
DPH-153893
DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂，对野生型 HIV-1 的 IC90 为 4 至 40 nM。
GC33930 Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid)
对羟基苯丙酸; 3-(4-Hydroxyphenyl)propionic acid
Phloretic acid (Desaminotyrosine, Hydro-p-coumaric acid, Phloretate, 3-(4-Hydroxyphenyl)propanoic acid) is a naturally occurring phenolic compound which can be produced by the hydrogenation of p-coumaric acid or synthesized from phloretin, a by-product of apple tree leaves.
GC33907 LP117 LP117是一种新型且有效的5-脂氧合酶(5-LO)产品合成抑制剂，其IC50值为1.1μM。
GC33905 CMI-392 CMI-392是一种双重5-lipoxygenese抑制剂和血小板活化因子(PAF)受体拮抗剂，IC50值分别为100和10nM。
GC33901 Pentanoic acid Pentanoicacid是一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。
GC33892 Cathepsin Inhibitor 2 CathepsinInhibitor2是一种有效的CathepsinS抑制剂，Ki值<20nM。详细信息请参考专利文献WO2009123623A1中的段落0229。
GC33889 N-Acetyl-Ser-Asp-Lys-Pro
戈雷拉肽,Ac-SDKP

N-Acetyl-Ser-Asp-Lys-Pro是ACE的N-末端位点的天然和特异性底物。
GC33885 UbcH5c-IN-1 UbcH5c-IN-1(compound6d)是一种有效的、选择性的小分子泛素结合酶UbcH5c抑制剂，其与E2UbcH5c-IN-1活性位点Cys85共价结合的Kd值为283nM，是开发新型类风湿性关节炎药物的先导化合物。
GC33881 Ro 31-9790 (GI4747)
GI4747
Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。
GC33860 25-Hydroxycholesterol
25-羟基胆固醇
25-羟基胆固醇是胆固醇代谢生成的一种侧链氧甾醇，由巨噬细胞响应 Toll 样受体(TLR)激活分泌。
GC33855 DL-α-Tocopherol acetate (Vitamin E acetate)
生育酚乙酸酯; Vitamin E acetate
DL-α-Tocopherol acetate (DL-Alpha-tocopherol acetate , Vitamin E acetate), a vitamin E derivative, is used as a vitamin E supplement in poultry feeds.
GC33853 Talabostat (PT100)
[(2R)-1-[(2S)-2-氨基-3-甲基丁酰基]吡咯烷-2-基]硼酸,Val-boroPro; PT100
Talabostat (PT100)是一种口服活性的二肽基肽酶IV DPP-IV IC50 < 4 nM的非选择性抑制剂;Ki = 0.18 nM，临床首个成纤维细胞活化蛋白FAP抑制剂IC50= 560 nM，抑制DPP 8/9的IC50= 4/11 nM;Ki = 1.5/0.76 nM，脯氨酸内肽酶QPP IC50= 310 nM, DPP2等DASH家族酶。
GC33846 Xanthine
黄嘌呤

A purine base
GC33839 Cortisone (17-Hydroxy-11-dehydrocorticosterone)
可的松
A precursor and metabolite of cortisol
GC33838 Taurocholic Acid sodium hydrate (Sodium taurocholate hydrate)
牛磺胆酸钠水合物; Sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate
Taurocholic acid (Sodium taurocholate hydrate), a bile salt formed in the liver, is the product of conjugation of cholic acid with taurine that is involved in the emulsification of lipids. Its sodium salt is the chief ingredient of the bile of carnivorous animals.
GC33830 Uridine triphosphate (UTP)
三磷酸尿苷; UTP; Uridine 5'-triphosphate
三磷酸尿苷 (UTP) (UTP;Uridine 5'-triphosphate) 是一种核苷酸，可在正常和疾病状态下调节胰腺在内分泌和外分泌分泌、增殖、通道、转运体和细胞内信号传导方面的功能。
GC33829 Papain (≥800u/mg)
木瓜酶
木瓜蛋白酶是一种具有广泛特异性的半胱氨酸蛋白酶，可切割碱性氨基酸、亮氨酸或甘氨酸的肽键。
GC33827 Uric acid
尿酸
Uric Acid (2,6,8-Trioxypurine, 2,6,8-Trihydroxypurine, 2,6,8-Trioxopurine), a normal component of urine, is a product of the metabolic breakdown of purine nucleotides.
GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
牛磺鹅去氧胆酸; 12-Deoxycholyltaurine

A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC33824 SDMA (Symmetric dimethylarginine)
对称N,N-二甲基精氨酸,Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine
SDMA (Symmetric dimethylarginine)是精氨酸的甲基化形式，是一氧化氮合酶（NOS）的内源性抑制剂。
GC33819 L-5,6,7,8-Tetrahydrofolic acid (THFA)
四氢叶酸; L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid
L-5,6,7,8-四氢叶酸 (THFA) (L-5,6,7,8-L-5,6,7,8-四氢叶酸 (THFA)) 是具有生物活性的维生素 B9 叶酸衍生物.
GC33818 18-Hydroxycorticosterone
18-羟基皮质酮

18-Hydroxycorticosterone是皮质类固醇和皮质酮的衍生物，可能会引起严重的电解质失衡。
GC33817 3,5-Dihydroxybenzoic acid 3,5-Dihydroxybenzoicacid是啤酒，坚果，花生和豆类等食物摄入的潜在生物标记。