Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC33815 4-Hydroxyphenylacetic acid
4-羟基苯乙酸
A phenolic acid with anti-inflammatory and anti-steatotic activities
GC33814 Glutaric acid
戊二酸
Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry.
GC33813 Xanthine oxidase-IN-1
4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid
Xanthine oxidase-IN-1 是一种黄嘌呤氧化酶抑制剂，提取自专利 WO2008126898A1，第 68 页，化合物实施例 3，IC50 为 6.5 nM。
GC33811 Pimelic acid (1,5-Pentanedicarboxylic acid)
庚二酸,Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid
Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.
GC33810 2-Methoxyestrone
2-甲基雌酮
An active metabolite of estrone
GC33808 Diacylglycerol acyltransferase inhibitor-1 Diacylglycerolacyltransferaseinhibitor-1是一个二酰基甘油酰基转移酶(DGAT1)抑制剂。
GC33807 Alloepipregnanolone
别孕烯醇酮
An Analytical Reference Standard
GC33806 Tricosanoic acid
二十三烷酸
A saturated fatty acid
GC33805 Adipic acid
己二酸
Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.
GC33804 Glycogen
糖原
Glycogen (糖原)是一种多糖，在动物和细菌中作为重要的能量储存分子。
GC33803 Pi-Methylimidazoleacetic acid
Pi-Methylimidazoleaceticacid是一种潜在的神经毒素。
GC33802 N-Acetyl-L-tyrosine
N-乙酰-L-酪氨酸
An active metabolite of, and precursor to, L-tyrosine
GC33801 1,5-Anhydrosorbitol
1,5-酐-D-山梨糖醇
1,5-anhydro-D-glucitol 是 D-glucitol 的脱水糖。它具有作为人体代谢物的作用，在功能上与D-葡萄糖醇有关，是评价短期血糖控制情况的指标
GC33800 10Z-Nonadecenoic acid
十九碳烯酸(顺-10)
10Z-Nonadecenoic acid 是一种具有抗肿瘤活性的长链脂肪酸。也可以抑制 p53 活性
GC33799 Ursocholic acid
熊果胆酸
A bile acid
GC33798 21-Hydroxypregnenolone 21-Hydroxypregnenolone是皮质酮合成的重要中间体。
GC33797 (3-Carboxypropyl)trimethylammonium chloride
(3-羧丙基)三甲基氯化铵,γ-Butyrobetaine hydrochloride
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.
GC33789 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE)
1,2-二硬酯酰-SN-甘油-3-磷酰乙醇胺,DSPE
A phospholipid
GC33779 Cysteamine (β-Mercaptoethylamine)
巯基乙胺
2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
GC33778 Hippuric acid (2-Benzamidoacetic acid)
马尿酸,2-Benzamidoacetic acid
Hippuric Acid (2-Benzamidoacetic acid, Benzoylglycine) is an acyl glycine produced by the conjugation of benzoic acid and glycine, found as a normal component in urine as a metabolite of aromatic compounds from food.
GC33777 Creatine
肌酸
Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue.Creatine can inhibits the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression.
GC33773 Elaidic acid
反油酸
A trans fatty acid
GC33769 Gemigliptin (LC15-0444)
吉格列汀酒石酸盐,LC15-0444
Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
GC33768 Deoxycholic acid sodium salt (Sodium deoxycholate)
脱氧胆酸钠; Sodium deoxycholate
Deoxycholic acid sodium salt (Sodium deoxycholate)是一种胆汁酸，是肠道代谢的副产物，可激活 G 蛋白偶联胆汁酸受体 TGR5。
GC33762 Deoxycholic acid (Cholanoic Acid)
去氧胆酸; Cholanoic Acid; Desoxycholic acid
Deoxycholic acid (Cholanoic Acid)是一种胆汁酸，肠道代谢副产物，可以激活G 蛋白偶联胆汁酸受体TGR5。
GC33748 Ethylmalonic acid
乙基丙二酸
Ethylmalonicacid是一种非致癌性的潜在有毒物质，与神经性厌食和甲氧基脱羧酶缺乏症有关。
GC33746 Dehydroascorbic acid
脱氢抗坏血酸
An oxidized form of ascorbic acid
GC33742 2-Hydroxyphenylacetic acid
邻羟基苯乙酸
2-Hydroxyphenylacetic acid (2-Hydroxybenzeneacetate, ortho-Hydroxyphenylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway styrene degradation.
GC33739 3-Methoxytyramine (3-O-methyl Dopamine)
4-(2-氨基乙基)-2-甲氧基苯酚,3-O-methyl Dopamine
3-Methoxytyramine (3-O-methyl Dopamine) 是一种众所周知的 3-羟基酪胺/多巴胺的细胞外代谢物，是一种神经调节剂。
GC33738 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride)
2-甲氧基-4-(2-氨基乙基)苯酚,3-O-methyl Dopamine hydrochloride
A natural metabolite of dopamine
GC33704 6-Hydroxymelatonin
苏达灭
An active metabolite of melatonin
GC33703 3,4,5-Trimethoxycinnamic acid
3,4,5-三甲氧基肉桂酸
3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.
GC33698 5-Hydroxyindole-3-acetic acid
5-羟基吲哚-3-乙酸
A metabolite of serotonin
GC33687 Glycoursodeoxycholic acid (Ursodeoxycholylglycine)
甘氨熊胆酸,Ursodeoxycholylglycine
A glycine-conjugated form of ursodeoxycholic acid
GC33672 Lurasidone Metabolite 14283 hydrochloride
鲁拉西酮缓解期代谢物14283
LurasidoneMetabolite14283hydrochloride是Lurasidone的主要的活性代谢物。
GC33663 Teprenone (Geranylgeranylacetone)
替普瑞酮; Geranylgeranylacetone

An inducer of Hsp expression
GC33661 Pseudouridine
假尿苷
The C-5 glycoside isomer of uridine
GC33660 Dulcite (Dulcitol)
甜醇; Dulcitol; Melampyrit; NSC 1944
A reduced form of galactose
GC33659 Indolelactic acid
3-吲哚乙酸,Indole-3-lactic acid
A metabolite of tryptophan
GC33656 4-Hydroxy-3-methylbenzoic acid
4-羟基-3-甲基苯甲酸
4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population.
GC33653 3-Methoxybenzoic acid (3-Anisic acid)
3-甲氧基苯甲酸,3-Anisic acid; 3-Methoxybenzoic acid; NSC 27014; NSC 9264; m-Methoxybenzoic acid
3-Methoxybenzoic acid (m-Anisic acid, 3-Methoxybenzoate, 3-Anisic acid, m-Methylsalicylic acid) is a food additive that acts as a flavouring ingredient.
GC33651 Imidazoleacetic acid
咪唑-4-乙酸,Imidazolyl-4-acetic acid
Imidazoleaceticacid是刺激咪唑受体(imidazolereceptors)的内源性配体。
GC33650 5,6-Dihydrouracil
二氢尿嘧啶; 5,6-Dihydrouracil
A catabolite of uracil
GC33649 3,4-Dihydroxybenzeneacetic acid
3,4-二羟基苯乙酸
A dopamine metabolite
GC33648 Taurocholic acid (N-Choloyltaurine)
牛磺胆酸; N-Choloyltaurine
A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications
GC33646 1-Methyladenine
1-甲基腺嘌呤
1-甲基腺嘌呤是在N-1位被甲基取代的腺嘌呤，是 DNA 烷基化损伤的产物，可通过氧化去甲基化损伤逆转进行修复。
GC33645 2-Guanidinoacetic acid
胍基乙酸,Guanidinoacetic acid
A metabolite of glycine and precursor in the biosynthesis of creatine
GC33643 2,6-Dimethoxybenzoic acid
2,6-二甲氧基苯甲酸
2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin.
GC33642 2,6-Dihydroxybenzoic acid
2,6-二羟基苯甲酸
2,6-Dihydroxybenzoic acid (γ-resorcylic acid, 2-Carboxyresorcinol, 2,6-Resorcylic acid) is a phenolic compound which is known to have poor biological performance such as DPPH scavenging activity and microbial growth inhibition.
GC33641 Hydroxyphenylacetylglycine
2-[2-(4-羟基苯基)乙酰氨基]乙酸
A metabolite of tyramine