Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC33640 Nepsilon-Acetyl-L-lysine
N-EPSILON-乙酰-L-赖胺基乙酸
Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins.
GC33637 2,5-Furandicarboxylic acid
2,5-呋喃二甲酸
2,5-Furandicarboxylic acid (Dehydromucic acid) is a normal urinary metabolite in humans and an important renewable building block because of its potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid.
GC33636 5'-Deoxyadenosine
5-脱氧腺嘌呤核苷
An adenosine analog
GC33635 N-Methylsarcosine (DMG)
N,N-二甲基甘氨酸; Dimethylglycine; DMG; N,N-Dimethylglycine
N-Methylsarcosine (N,N-Dimethylglycine, (Dimethylamino)acetic acid) is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers.
GC33633 2-(2-Methylbenzamido)acetic acid
2-甲基马尿酸
A metabolite of xylene
GC33631 3-Chloro-L-tyrosine
3-氯-L-酪氨酸
A derivative of L-tyrosine
GC33630 Tryptamine
色胺
An indole alkaloid
GC33629 DPPC (129Y83)
二棕榈酰磷脂酰胆碱; 129Y83
DPPC (129Y83)是一种磷酸甘油酯，可用于制备脂质体。
GC33628 Epipregnanolone
孕烷醇酮
A neurosteroid and an active metabolite of pregnenolone
GC33626 2,4-Dihydroxybenzoic acid
2,4-二羟基苯甲酸
2,4-Dihydroxybenzoic acid (β-resorcylic acid, p-Hydroxysalicylic acid) is a degradation product of cyanidin glycosides from tart cherries in cell cultures and a metabolite found in human plasma after cranberry juice consumption.
GC33625 N8-Acetylspermidine dihydrochloride
N8-乙酰基亚精胺二盐酸盐
An endogenous polyamine
GC33622 2',4'-Dihydroxyacetophenone
2,4-二羟基苯乙酮,Resacetophenone; 1-?(2,?4-?Dihydroxyphenyl)?ethanone
2,4-Dihydroxyacetophenone (Resacetophenone, 4-Acetylresorcinol) is a plant metabolite that can act as a qualitative reagent for ferric iron.
GC33621 1,2-Dipalmitoyl-sn-glycerol 3-phosphate
1,2-二棕榈酰磷脂酸
1,2-Dipalmitoyl-sn-glycerol3-phosphate是一种磷脂酸。
GC33618 3-(3,4,5-Trimethoxyphenyl)propanoic acid
3-(3,4,5-三甲氧基苯基)丙酸
3-(3,4,5-Trimethoxyphenyl)propanoicacid存在于草药和香料中。3-(3,4,5-Trimethoxyphenyl)propanoicacid是Piperlongum(长胡椒)和Piperretrofractum(爪哇长胡椒)的成分。
GC33617 Hexacosanoic acid
蜡酸
A 26-carbon saturated fatty acid
GC33616 7-Methylguanine
7-甲基鸟嘌呤
A nucleotide metabolite
GC33615 3,4-Dimethoxyphenylacetic acid
3,4-二甲氧基苯乙酸
Homoveratrumic acid (Homoveratric acid) is the main metabolite of 3,4-dimethoxyphenylethylamine (DMPEA) in urine.
GC33613 5-Hydroxymethyluracil
5-羟甲基脲嘧啶
Product of oxidative damage to DNA
GC33612 N-Acetyl-L-aspartic acid
N-乙酰-L-天门冬氨酸
An acetylated form of L-aspartic acid
GC33610 4-Hydroxycyclohexanecarboxylic acid
4-羟基环己烷甲酸
4-Hydroxycyclohexanecarboxylicacid属于环己醇有机化合物类。
GC33608 Malic acid (E 296)
DL-苹果酸; Hydroxybutanedioic acid; E 296
The racemate of L-malic acid
GC33607 Hydrocinnamic acid (3-Phenyl-n-propionic acid)
3-苯丙酸; 3-Phenylpropionic acid; 3-Phenylpropanoic acid; 3-Phenyl-n-propionic acid
Hydrocinnamic acid (3-phenylpropionic acid, Benzylacetic acid) is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite.
GC33606 D-(+)-Glucono-1,5-lactone (Gluconic acid lactone)
葡萄糖酸内酯,Gluconic acid lactone
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
GC33605 2'-Deoxyadenosine monohydrate
2'-脱氧腺苷一水合物
A deoxyribonucleoside
GC33604 3-Pyridineacetic acid
3-吡啶乙酸
3-Pyridineaceticacid是尼克酸的高同系物，是尼古丁（和其它烟草生物碱）的分解产物。
GC33603 Dihydrofolic acid
二氢叶酸
An active metabolite of folic acid
GC33602 Decanoic acid
癸酸
Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
GC33594 Cytosine
胞嘧啶
A pyrimidine base
GC33579 Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
卡维地洛对羟基代谢物,4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol
An active metabolite of carvedilol
GC33578 Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
N-去甲盐酸伊伐布雷定,N-Demethyl ivabradine hydrochloride
An active metabolite of ivabradine
GC33571 Duloxetine metabolite Para-Naphthol Duloxetine (Para-Naphthol duloxetine)
度洛西汀代谢物; Para-Naphthol duloxetine
对萘酚度洛西汀是度洛西汀的代谢产物，度洛西汀是一种血清素去甲肾上腺素再摄取抑制剂 (SNRI)。
GC33564 Lurasidone metabolite 14326
鲁拉西酮缓解期代谢物14326
An active metabolite of lurasidone
GC33563 Netupitant metabolite N-desmethyl Netupitant (N-desmethyl Netupitant)
奈妥匹坦杂质B,N-desmethyl Netupitant

N-desmethyl Netupitant 是 Netupitant 的代谢物，Netupitant 是一种止吐药。
GC33559 Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant)
奈妥匹坦杂质A,Monohydroxy Netupitant
Monohydroxy Netupitant 是 Netupitant 的代谢物，Netupitant 是一种高选择性的 NK1 受体拮抗剂。
GC33558 Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen)
对乙酰氨基酚代谢物; 3-Hydroxyacetaminophen
3-羟基-对乙酰氨基酚是对乙酰氨基酚的代谢物，它是一种止痛药。
GC33548 Netupitant metabolite Netupitant N-oxide (Netupitant N-oxide)
奈妥吡坦杂质,Netupitant N-oxide

A metabolite of netupitant
GC33532 Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate)
甲基孕酮,17-Deacetyl norgestimate; 17-Deacylnorgestimate
An active metabolite of norgestimate
GC33526 5-Methylcytidine
5-甲基胞苷
A modified nucleoside
GC33525 3-Methyluridine
3-甲基尿苷,N3-Methyluridine
3-Methyluridine是细胞RNA的修饰核苷。
GC33519 2,5-Dihydroxybenzoic acid
2,5-二羟基苯甲酸
A benzoic acid with diverse biological activities
GC33518 N-Acetylputrescine hydrochloride
N-(4-氨基丁基)-乙酰胺
N-Acetylputrescinehydrochloride是一种腐胺衍生物。
GC33514 5-Methyluridine
5-甲基尿苷
A pyrimidine nucleoside
GC33504 4-Acetamidobutanoic acid (N-acetyl GABA)
4-乙酰氨基丁酸,N-acetyl GABA
A GABA derivative
GC33502 5,6-Dihydrouridine
5,6-二氢尿苷
A pyrimidine nucleoside and derivative of uridine
GC33496 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine)
6-羟基-2-氨甲基嘌呤,N2-methylguanine
2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) 是一种修饰的核苷。
GC33495 N-Desmethyl imatinib
N-去甲基伊马替尼; Norimatinib; Imatinib metabolite N-Desmethyl imatinib
A major active metabolite of imatinib
GC33484 Ampyrone (4-Aminoantipyrine)
4-氨基安替比林
4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
GC33471 p-Hydroxycinnamic acid (NSC 59260)
对羟基肉桂酸
p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.
GC33464 Oxyresveratrol (trans-Oxyresveratrol)
氧化白藜芦醇; trans-Oxyresveratrol
A resveratrol analog
GC33463 1-Methyladenosine
1-甲基腺苷
1-甲基腺苷是一种在1 位带有甲基取代基的甲基腺苷。它具有作为人体代谢物的作用，在功能上与腺苷有关