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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC31626 Bovinic acid

    共轭(9Z11E)亚油酸,Bovinic acid; 9Z,11E-CLA; Rumenic Acid

    An isomer of linoleic acid
  3. GC31625 3-(3-Methoxyphenyl)propionic acid

    3-(3-甲氧基苯基)丙酸

     3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine.
  4. GC31624 D-Xylulose

    D-木酮糖

    A ketopentose
  5. GC31622 (S)-2-Hydroxysuccinic acid

    L-苹果酸; (S)-Hydroxybutanedioic acid; (S)-E 296

     (S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.
  6. GC31620 L-(-)-Fucose

    L(-)岩藻糖,6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose

    A monosaccharide important for immune function
  7. GC31619 Decanedioic acid

    癸二酸

     Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid
  8. GC31617 7-Methylxanthine

    7-甲基黄嘌呤

     An adenosine A1 receptor antagonist and active metabolite of theobromine and caffeine
  9. GC31612 Thiamine pyrophosphate

    焦磷酸硫胺素

    A metabolite of vitamin B1
  10. GC31611 2-Phenylpropionic acid

    2-苯基丙酸

     2-Phenylpropionic acid (2-Phenylpropionate, Hydratropic acid, α-methyl-α-toluic acid) is an intermediate in alpha-Methylstyrene (2-phenylpropylene) metabolism.
  11. GC31610 1-Methyluric acid

    1-甲基尿酸

    1-甲基尿酸是人体三种主要的茶碱代谢物之一。1-甲基尿酸是尿路结石中的嘌呤成分之一。甲基化嘌呤来源于甲基黄嘌呤（咖啡因、茶碱和可可碱）的代谢。作用于膀胱黏膜，并能增加血糖，胰岛素，甘油三酯和胆固醇的水平。
  12. GC31609 Glutarylcarnitine

    戊二酰基肉碱

    Glutarylcarnitine丙二酸尿症和I型戊二酸尿症的重要诊断代谢物。
  13. GC31608 Candoxatril (UK 79300)

    坎沙曲,UK 79300

     Candoxatril (UK 79300) 是一种中性肽链内切酶 (NEP) 抑制剂。
  14. GC31606 Docosanoic acid

    二十二酸

     A long-chain saturated fatty acid
  15. GC31605 N-Isovaleroylglycine

    N-异戊酰氨基乙酸

     A urinary metabolite of leucine
  16. GC31603 Delta-Tocopherol

    (+)-DELTA-生育酚

    A biologically active form of vitamin E
  17. GC31602 Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid)

    廿二碳四烯酸,Adrenic Acid

     A naturally-occurring PUFA formed through elongation of arachidonic acid
  18. GC31595 3-Methylbutanoic acid

    异戊酸

    3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery.
  19. GC31594 DL-O-Phosphoserine

    DL-O-磷酸丝氨酸

     DL-O-Phosphoserine是人类生物流体中的正常代谢物，是丝氨酸和磷酸的酯。
  20. GC31590 Cholestenone

    胆甾烯酮; 4-Cholesten-3-one

     A cholesterol metabolite
  21. GC31588 L-Hexanoylcarnitine L-Hexanoylcarnitine是一种酰基肉碱，被发现和乳糜泻有关。
  22. GC31587 L-Homocitrulline

    高瓜氨酸

     An amino acid and a product of carbamylation
  23. GC31584 Indole-3-carboxylic acid

    3-吲哚甲酸

     A plant metabolite with diverse biological activities
  24. GC31583 SQ28603 (SQ28,603)

    SQ28,603; Squibb 28603

     SQ28603 (SQ28,603) 是中性肽链内切酶 3.4.24.11 (NEP) 的有效选择性抑制剂，NEP 是一种降解心房利钠肽 (ANP) 的酶。
  25. GC31581 Pyridoxylamine

    吡多胺

     Pyridoxylamine是糖基化终产物(AGE)和脂质化终产物(ALE)抑制剂，可防止糖尿病引起的视网膜血管病变。
  26. GC31576 Glycodeoxycholate Sodium (Sodium glycyldeoxycholate)

    脱氧甘胆酸钠,Sodium glycyldeoxycholate

     Glycochenodeoxycholic acid (GCDC, Glycodeoxycholate, Deoxycholylglycine) is a bile salt that is used as an anionic detergent to solubilize lipids.
  27. GC31575 Porphobilinogen

    紫質膽素原

     Porphobilinogen可以作为一种光毒素，神经毒素和代谢毒素。
  28. GC31574 Undecanedioic acid

    十一烷二酸

     Undecanedioic acid (1,9-Nonanedicarboxylic acid, Undecanedionate) is a long-chain dicarboxylic acid that has applications in corrosion inhibitors, hot melt adhesives, high performance polyamides/Nylon, and more.
  29. GC31572 Octanedioic acid

    辛二酸,Octanedioic acid

    Octanedioic acid (Suberic acid) is a dicarboxylic acid used in drug syntheses and plastics manufacture.
  30. GC31571 Isomaltose (6-O-α-D-Glucopyranosyl-D-glucose)

    异麦芽糖; 6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose

    A natural disaccharide
  31. GC31570 Tiglyl carnitine Tiglylcarnitine被发现和乳糜泻，线粒体乙酰辅酶A硫代酶(T2)缺乏症有关。
  32. GC31569 3-Amino-2-methylpropanoic acid

    3-氨基异丁酸

     3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine.
  33. GC31564 BAY-85-8501 BAY-85-8501是人类中性脂酶(HNE)的一个有效的、选择性抑制剂，其IC50值为65pM。
  34. GC31562 Guanylic acid (5'-GMP)

    鸟苷酸; 5'-GMP; 5'-guanosine monophosphate

    鸟苷酸 (5'-GMP) (5'-GMP) 涉及多种代谢紊乱，包括 AICA-核糖苷尿途径、腺苷脱氨酶缺乏症、腺嘌呤磷酸核糖基转移酶缺乏症 (aprt) 和 2-羟基戊二酸尿症途径。
  35. GC31559 Thymine

    胸腺嘧啶

    Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
  36. GC31556 RPR107393 free base RPR107393freebase是一种有效的选择性角鲨烯合酶(squalenesynthase)抑制剂，抑制鼠肝微粒体角鲨烯合成酶，IC50值为0.8±0.2nM。
  37. GC31555 MGAT2-IN-2 MGAT2-IN-2是一种有效的选择性酰基辅酶A:单酰甘油酰基转移酶2(MGAT2)抑制剂，IC50为3.4nM。
  38. GC31553 3b-Hydroxy-5-cholenoic acid

    3B-羟基-D5-胆烯酸

     A bile acid
  39. GC31551 FR-190809 FR-190809是一种有效、可口服、无肾上腺毒性的酰基辅酶A-胆固醇酰基转移酶(ACAT)抑制剂，IC50值为45nM。
  40. GC31550 E-5324

    E-5324是一个强效的酰基辅酶A:胆固醇酰基转移酶(ACAT)抑制剂，其IC50值在44至190nM之间。
  41. GC31549 Glycolic acid

    乙醇酸

     Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
  42. GC31548 ACAT-IN-1 cis isomer ACAT-IN-1cisisomer是有效地ACAT抑制剂，IC50值为100nM。
  43. GC31547 DPP-IV-IN-1 DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂，IC50值为4.6nM；DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。
  44. GC31546 3-Methyladipic acid

    3-甲基己二酸

     A catabolite of phytanic acid
  45. GC31544 2-Hydroxy-2-methylbutanoic acid

    2-羟基-2-甲基丁酸

     2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME).
  46. GC31540 Methionine sulfoxide

    DL-蛋氨酸亚砜

    Methioninesulfoxide是一种具有活性氧的甲硫氨酸的氧化产物，可被当做体内氧化应激的生物标记。
  47. GC31539 D-Gluconic acid solution

    葡萄糖酸; 葡萄糖醛酸

    D-Gluconic acid is an antifungal agent.
  48. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine α-amidating enzyme
  49. GC31535 3-Methyl-L-histidine

    3-甲基-L-组氨酸

     An amino acid
  50. GC31524 Glycylglycine

    双甘肽

    Glycylglycine (Diglycine, Diglycocoll, Glycine dipeptide), the simplest peptide made of two glycine molecules, is usually used in the synthesis of more complicated peptides.
  51. GC31516 YM-53601 free base A squalene synthase inhibitor

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