Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC31219 8-Hydroxyguanosine
8-羟基鸟苷
An oxidized nucleoside and a marker of RNA oxidative damage
GC31210 Paraxanthine
1,7-二甲基黄嘌呤
An active metabolite of caffeine
GC31186 Citicoline sodium salt
胞磷胆碱钠; Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium

An intermediate in the synthesis of phosphatidylcholine
GC31180 Royal Jelly acid (Queen Bee Acid)
王浆酸; Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid
An unsaturated fatty acid found in royal jelly
GC31123 Mitochonic acid 5 (MA-5)
MA-5
An inhibitor of mitochondrial dysfunction
GC31118 KU-32 KU-32是一种新型的，基于新生霉素的Hsp90抑制剂，可以预防神经细胞死亡。
GC31103 Arimoclomol maleate (BRX-220)
BRX-220
A co-inducer of heat shock proteins
GC31080 GOAT-IN-1 GOAT-IN-1是胃促生长素O-酰基转移酶(GOAT)的抑制剂，可用于预防或治疗肥胖、糖尿病、高脂血症、非酒精性脂肪肝、脂肪性肝炎、骨骼肌减少症、食欲控制、酒精/麻醉性依赖、阿尔茨海默症、帕金森、脑血管疾病与老年痴呆、脑卒中、脑梗死、心血管疾病、一些肿瘤等。
GC31012 BMS 433796
(ALPHAS)-N-[(1S)-2-[[(5S)-4,5-二氢-3-甲基-4-氧代-3H-2,3-苯并二氮杂卓-5-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-ALPHA-羟基苯乙酰胺
BMS433796是一种γ-分泌酶抑制剂，用于阿尔茨海默氏病转基因小鼠模型，可降低Aβ活性。
GC30994 Vanilpyruvic acid (Vanylpyruvic acid)
4-羟基-3-甲氧基苯基丙酮酸,Vanylpyruvic acid
香草丙酮酸 (Vanylpyruvic acid) 是儿茶酚胺代谢物和香草乳酸的前体。
GC30954 Itanapraced (CHF5074)
CHF5074; CSP-1103
A modulator of γ-secretase
GC30887 NGP555 A γ-secretase modulator
GC30877 DPP-IV-IN-2 DPP-IV-IN-2是二肽基肽酶IV(DPIV)和DP8/9的抑制剂，其IC50值分别为0.1和0.95μM。
GC30872 Pipecolic acid
六氢吡啶-alpha-羧酸；哌啶-2-甲酸；呢可酸；2-哌啶甲酸
Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.
GC30842 Androsterone (5α-Androstan-3α-ol-17-one)
雄酮; 5α-Androstan-3α-ol-17-one

An androgenic steroid
GC30806 Cyclo(his-pro) (Cyclo(histidyl-proline))
环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine
A cyclic neuropeptide and metabolite of TRH
GC30795 D-Galactose (D-(+)-Galactose)
D-半乳糖; D-(+)-Galactose

A natural aldohexose
GC30786 Sacubitrilat (LBQ-657)
LCZ696杂质,Desethyl Sacubitril; LBQ-657
A neprilysin inhibitor
GC30783 AZD5904 A myeloperoxidase inhibitor
GC30775 Histamine (Ergamine)
组胺; Ergamine

A biogenic amine
GC30767 Heparan Sulfate
硫酸乙酰肝素

硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。
GC30765 Docosahexaenoic Acid (DHA)
二十二碳六烯酸; DHA; Cervonic acid
二十二碳六烯酸 (DHA) 是一种长链多不饱和脂肪酸，对婴儿和成人均有活性。
GC30760 Pentadecanoic acid
十五烷酸
A saturated fatty acid
GC30758 m-Coumaric acid
3-羟基肉桂酸
m-Coumaricacid是来自咖啡酸的多酚代谢物，由肠道微生物群形成，体液中的量是饮食依赖性的。
GC30757 DL-Homocysteine thiolactone hydrochloride
DL-高半胱氨酸硫内酯盐酸盐
A derivative of DL-homocysteine
GC30753 Ureidopropionic acid
3-酰脲丙酸,3-Ureidopropionic acid
Ureidopropionic acid is an intermediate in the metabolism of uracil.
GC30749 1,3-Dimethyluric acid
1,3-二甲基尿酸
1,3-二甲基尿酸（1,3-Dimethyluric acid）是一种氧嘌呤，它是 7,9-二氢-1H-嘌呤-2,6,8(3H)-三酮，在 N-1 和 N-3 被甲基取代。是人体茶碱代谢的产物。1,3-二甲基尿酸是尿路结石中的嘌呤成分之一。
GC30745 L-Palmitoylcarnitine
棕榈酰肉碱
L-Palmitoylcarnitine是脂肪酸代谢物。
GC30744 Norepinephrine (Adrenor)
去甲肾上腺素; Levarterenol; L-Noradrenaline

(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
GC30742 1,3-Diaminopropane 1,3-Diaminopropane是一种三碳二胺，是鸟氨酸脱羧酶抑制剂。
GC30735 (S)-Leucic acid
(S)-2-羟基-4-甲基戊酸
Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.
GC30732 Guanosine (DL-Guanosine)
鸟嘌呤核苷; 鸟苷; DL-Guanosine; Vernine

A purine nucleoside
GC30730 Monoisobutyl phthalic acid
苯二甲酸单异丁酯
Monoisobutylphthalicacid是一种邻苯二甲酸酯代谢物，存在于人的精液和肽粪中。
GC30729 3-Hydroxyvaleric acid
3-羟基戊酸

3-Hydroxyvalericacid是一种五碳酮体。3-Hydroxyvalericacid可以发生回补反应，即可以补充三羧酸循环的中间产物。
GC30728 Isobutyryl-L-carnitine
异丁酰-L-肉碱
An acylcarnitine
GC30727 Beta-Cortol
NSC 58792
An endogenous metabolite of cortisol
GC30726 Eicosadienoic acid
二十碳二烯酸
An uncommon, naturally occurring PUFA
GC30724 trans-Vaccenic acid
反式-11-十八烯酸
An ω-7 fatty acid
GC30723 Ubiquinone-1
辅酶Q1

An electron acceptor
GC30722 Anserine
L-鹅肌肽
Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.
GC30720 2-Naphthol
β-萘酚
2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds.
GC30719 3-Amino-4-methylpentanoic acid
3-氨基-4-甲基戊酸
3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite.
GC30718 2-Amino-1-phenylethanol
2-氨基-1-苯乙醇
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
GC30716 Levulinic acid (4-Oxovaleric acid)
乙酰丙酸; 4-Oxovaleric acid; NSC 3716
Levulinic acid (4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid) is used as a precursor for pharmaceuticals, plasticizers, and various other additives.
GC30715 Guanosine 5'-diphosphate
鸟苷-5ˊ-二磷酸二钠盐(酵母),GDP
Guanosine5'-diphosphate是一种核苷酸，组成物是焦磷酸基团、五碳糖、以及碱基鸟嘌呤。Guanosine5'-diphosphate是三磷酸鸟苷(GTP)经过去磷酸化之后的产物。
GC30713 2-Oxovaleric acid
2-戊酮酸

2-Oxovalericacid是在人体血液中发现的一种酮酸。
GC30712 5-Methoxytryptophol
5-甲氧基色醇
A natural indole
GC30711 D-Threitol
D-苏糖醇

D-threitol可以作为阿拉斯加甲虫的防冻剂。
GC30708 Terephthalic acid
对苯二甲酸

Terephthalic acid (para-Phthalic acid, 1,4-Benzenedioic acid), a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry.
GC30707 DL-Dopa
DL-多巴
DL-Dopa (3,4-Dihydroxy-DL-phenylalanine) is an immediate precursor of dopamine.