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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC30706 Maltotriose

    麦芽三糖

     A trisaccharide
  3. GC30704 Urocanic acid

    尿刊酸

    Urocanic acid is an intermediate in the catabolism of L-histidine.
  4. GC30698 L-Octanoylcarnitine L-Octanoylcarnitine是辛酰基肉碱的生理活性形式。
  5. GC30697 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 是组胺 (Him) 代谢物。
  6. GC30691 N-Methylhydantoin

    甲酰乙内脲

    N-Methylhydantoin (1-Methylhydantoin, Dioxy-creatinine) is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam.
  7. GC30690 m-Tyramine

    3-羟苯乙胺盐酸盐

    m-Tyramine是一种内源性微量胺神经调节剂。m-Tyramine对肾上腺素能(adrenergic)和多巴胺能受体(dopaminergic)有影响。
  8. GC30686 Nervonic acid (Selacholeic acid)

    神经酸; Selacholeic acid; cis-15-Tetracosenoic acid

     A very long chain fatty acid abundant in sphingomyelin
  9. GC30684 DL-Homocysteine

    DL-高半胱氨酸

     An amino acid
  10. GC30683 Gln-AMS Gln-AMS是一种氨基酰基-tRNA合成酶(AARS)抑制剂，与非核糖体多肽合成酶(NRPS)A结构域结合。
  11. GC30677 Hexadecanedioic acid

    十六碳二酸

    A dicarboxylic fatty acid
  12. GC30675 Argininic acid

    (S)-5-胍基-2-羟基戊酸

    Argininicacid是一种α-氨基酸，用于蛋白质的生物合成。Argininicacid是一种碱性氨基酸。
  13. GC30672 2,3-Diaminopropionic acid

    L-2,3-二氨基丙酸

    2,3-Diaminopropionicacid是神经毒性氨基酸b-oxalyl-L-a,b-diaminopropionicacid的代谢产物。
  14. GC30671 2-Methylpentanedioic acid

    2-甲基戊二酸

    2-Methylglutaric acid (alpha-Methylglutaric acid) is a metabolite of succinic acid, a citric acid cycle intermediate.
  15. GC30670 4-Pyridoxic acid

    4-吡哆酸

     A pyridoxine metabolite
  16. GC30669 5α-Cholestan-3β-ol (5α-Cholestanol)

    二氢胆固醇,Dihydrocholesterol; 5α-Cholestanol; NSC 18188

     A cholesterol metabolite
  17. GC30668 Myristic acid

    肉豆蔻酸; 十四酸

    A saturated fatty acid
  18. GC30661 (R)-3-Hydroxyisobutyric acid

    (R)-2-羟甲基丙酸

    (R)-3-Hydroxyisobutyricacid是l-缬氨酸和胸腺嘧啶途径中的中间产物，在诊断罕见遗传性代谢疾病3-羟异丁酸和甲基丙二醛脱氢酶缺乏症中起着重要的作用。
  19. GC30660 3-Hydroxyisovaleric acid

    β-羟基异戊酸

     An active metabolite of L-leucine
  20. GC30658 4-Methylcatechol

    4-甲基儿茶酚

     4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.
  21. GC30654 Oxoadipic acid

    2-氧代己二酸

    An intermediate in the catabolism of L-tryptophan, L-lysine, and hydroxylysine
  22. GC30652 Melanin

    黑色素

     Melanin是一种具有多功能的生物色素，可以抵御环境压力，如紫外线(UV)，氧化剂和电离辐射。
  23. GC30651 Decyl aldehyde

    癸醛

    Decyl aldehyde (Decanal, Capraldehyde, Decanaldehyde) is a naturally occuring organic compound that is used in fragrances and flavoring.
  24. GC30649 (S)-3,4-Dihydroxybutyric acid (S)-3,4-Dihydroxybutyricacid是一种正常的人体尿液代谢物，在琥珀酸半醛脱氢酶(SSADH)缺乏症患者中浓度增加。
  25. GC30646 Skatole(3-Methylindole)

    粪臭素; 3-Methylindole; 3-Methyl-1H-indole

     Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
  26. GC30645 p-Hydroxymandelic acid

    4-羟基扁桃酸

     p-Hydroxymandelicacid是一种有价值的芳香类化学品，广泛用于生产药物和食品添加剂。
  27. GC30642 3-Hydroxydodecanoic acid

    3-羟基月桂酸

    A hydroxy fatty acid
  28. GC30641 1-Naphthol (Fourrine ERN)

    1-萘酚,Furro ER; NSC 9586; Nako TRB

     1-萘酚（1-Naphthol）用于制造染料、中间体、合成香料，是一种激发态质子转移 (ESPT) 荧光分子探针
  29. GC30640 Homogentisic acid

    尿黑酸

     An intermediate in aromatic amino acid metabolism
  30. GC30638 3-Hydroxymandelic Acid

    3-羟基扁桃酸

     3-HydroxymandelicAcid是Phenylephrine的代谢物，Phenylephrine是α受体(α-receptor)的激动剂。
  31. GC30636 3-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI))

    3-羟基-2-吡啶甲酸,Picolinic acid, 3-hydroxy- (6CI,7CI,8CI); 2-Carboxy-3-hydroxypyridine

     A matrix substance for MALDI-MS
  32. GC30635 3-Methylxanthine

    3-甲基黄嘌呤

     A cGMP PDE inhibitor and metabolite of theophylline and caffeine
  33. GC30632 Dodecanedioic acid

    十二烷二酸

     Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics.
  34. GC30631 Paullinic acid

    二十烯酸,13(Z)-Eicosenoic Acid

    An ω-7 fatty acid
  35. GC30630 4-Guanidinobutanoic acid

    4-胍基丁酸

    4-Guanidinobutanoate (4-Guanidinobutanoate, gamma-Guanidinobutyric acid, gamma-Guanidinobutanoate) is a normal metabolite present in low concentrations.
  36. GC30629 2-Oxobutanoic acid

    2-丁酮酸

    2-Oxobutanoic acid (2-Oxobutyrate, 2-ketobutyric acid, 2-oxobutyric acid, alpha-ketobutyric acid, α-ketobutyric acid) is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism.
  37. GC30624 L-Alloisoleucine ((3R)-LS-Isoleucine)

    L-别异亮氨酸; (3R)-LS-Isoleucine; L-Allo-isoleucine

     A branched-chain amino acid
  38. GC30623 (S)-3-Hydroxyisobutyric acid

    2-甲基-3-羟基丙酸

     (S)-3-Hydroxyisobutyric acid 是一种重要的器官间代谢物，是 l-缬氨酸和胸腺嘧啶途径的中间体，也是良好的糖异生底物。
  39. GC30622 2-Oxo-3-phenylpropanoic acid

    苯丙酮酸

     2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase.
  40. GC30620 D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate)

    D(+)-五水棉子糖; D-Raffinose pentahydrate

     A natural trisaccharide
  41. GC30618 Orotidine

    乳清酸核苷

     A pyrimidine nucleoside
  42. GC30617 Tetradecanoylcarnitine Tetradecanoylcarnitine是人体中的肉毒碱，参与长链脂肪酸的β型氧化。
  43. GC30616 3-Hydroxybutyric acid

    3-羟基丁酸; β-Hydroxybutyric acid

     3-羟基丁酸（3-Hydroxybutyric acid，D-β-hydroxybutyrate，BHB）是一类组蛋白脱乙酰酶（HDAC）的内源性和特异性抑制剂，抑制HDAC1、HDAC3和HDAC4的IC50分别为5.3、2.4和4.5 mM。
  44. GC30615 Nicotinuric acid

    烟酰甘氨酸

    A metabolite of niacin
  45. GC30613 5-Hydroxydopamine hydrochloride

    5-羟基多巴胺盐酸盐

    5-Hydroxydopamine是人尿液中天然存在的胺。
  46. GC30612 2-Hydroxyadipic acid

    2-羟基己二酸二钠盐

     A dicarboxylic fatty acid
  47. GC30610 LY 178002

    LY178002是一种有效的5-lipoxygenase，phospholipaseA2抑制剂，对5-lipoxygenase的IC50值为0.6μM，能够抑制人多形核白细胞产生LTB4，同时可相对较弱地抑制cyclooxygenase的活性。
  48. GC30603 3-Hydroxyhippuric acid

    3-羟基马尿酸

     3-Hydroxyhippuricacid是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。
  49. GC30600 4-Ethylphenol

    4-乙基苯酚

     4-Ethylphenol (P-Ethylphenol, 4-Hydroxyphenylethane) is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces.
  50. GC30598 Citraconic acid

    柠康酸

     Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean.
  51. GC30593 3-Methyl-2-oxovaleric acid

    3-甲基-2-氧基戊酸

     3-Methyl-2-oxovalericacid是一种神经毒素，一种酸性原和一种代谢毒素，它是由支链氨基酸不完整分解产生的异常的代谢物。

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