Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC18869 Deoxyenterocin
5-Deoxyenterocin
A bacterial metabolite with diverse biological activities
GC18845 Leukotriene F4
白三烯,LTF4
A CysLT produced in vitro from LTE₄
GC18835 Leukotriene A4 methyl ester
LTA4 methyl ester

A stable form of LTA₄
GC18832 Conglobatin An Hsp90 inhibitor
GC18831 Tolmetin β-D-Glucuronide A major phase II metabolite of tolmetin
GC18817 3β-hydroxy-5-Cholestenoic Acid
3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid
An active cholesterol metabolite
GC18791 Prostaglandin H1
前列腺素H1
The precursor to all 1-series prostaglandins and thromboxanes
GC18728 CJ-13610 An inhibitor of 5-LO
GC18709 D-NMMA (acetate)
NG-单甲基-D-精氨酸醋酸盐
A control compound for studying NOS inhibition
GC18706 SR 9186
ML368
A selective inhibitor of CYP3A4
GC18705 ML-210
DPI10
A GPX4 inhibitor
GC18702 Propiverine N-oxide (hydrochloride) An active propiverine metabolite
GC18699 JCP174
7-amino-4-chloro-3-Propoxyisocoumarin
An inhibitor of palmitoyl protein thioesterase-1
GC18688 CAY10589 Dual Inhibitor of mPGES-1 and 5-LO
GC18681 Lipoxin B4
LXB4
A positional isomer of LXA₄
GC18680 Lipoxin A4 methyl ester
LXA4 methyl ester
A lipid soluble, prodrug of LXA₄
GC18663 Leukotriene C4
白三烯C4
The parent cysteinyl leukotriene produced by LTC₄ synthase catalyzed conjugation of glutathione to LTA₄
GC18659 Ribavirin 5'-monophosphate (lithium salt)
利巴韦林5'-单磷酸二锂盐
A potent, broad-spectrum antiviral agent
GC18654 8-hydroxy Loxapine
8-OH Loxapine
A loxapine metabolite
GC18646 Myristelaidic Acid
十四碳烯酸(反-9),trans-9-Tetradecenoic acid

A monounsaturated ω-5 fatty acid
GC18641 Ferutinin An ERα agonist
GC18632 6-hydroxy Bexarotene
6-羟基蓓萨罗丁
An oxidative metabolite of bexarotene
GC18628 3-Methylcrotonyl Glycine
N-(3-甲基-1-氧代-2-丁烯基)氨基乙酸
A metabolite with diverse biological activities
GC18622 (2'S)-Nicotine-1-oxide
(2'S)-尼古丁氧化物
A nicotine metabolite
GC18621 Antimycin A2
丁酸-3-[(3-甲酰-2-羟基苯甲酰基)氨基]-8-己基-2,6-二甲基-4,9-二氧-1,5-二酰-7-酯
An active component of the antimycin A antibiotic complex
GC18616 MMP-8 Inhibitor I
Matrix Metalloproteinase-8 Inhibitor I
A selective inhibitor of MMP-8
GC18612 MMP-9/MMP-13 Inhibitor I
Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I
An MMP inhibitor
GC18608 MMP-2/MMP-9 Inhibitor II
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II
A dual inhibitor of MMP-2 and MMP-9
GC18596 (±)-2-propyl-4-Pentenoic Acid
2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
A metabolite of valproic acid
GC18583 D-α-Hydroxyglutaric Acid
R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

An α-hydroxy acid
GC18582 5'-hydroxy Meloxicam
5'-羟基美洛昔康
A metabolite of meloxicam
GC18580 B355252 A neuroprotective agent
GC18569 Propofol β-D-Glucuronide
2,6-二异丙基Β-D-吡喃葡萄糖酸

A metabolite of propofol
GC18567 β-hydroxy Pyruvic Acid
[癸烷酸与2-乙基-2-(羟甲基)-1,3-丙二醇辛酯]的酯化物,3-hydroxy-2-Oxopropanoic acid
A metabolite in the process of photorespiration
GC18561 TZ9 A Rad6B inhibitor
GC18552 Lipoxin A4
脂氧素 A4; LXA4

Produced by the metabolism of 15-HETE or 15-HpETE with leukocytes
GC18544 8-dehydro Cholesterol An isomer of 7-DHC
GC18542 5,6-dihydro-5-Fluorouracil
5-氟二氢嘧啶-2,4-二酮
A metabolite of 5-FU
GC18539 all-trans-4-hydroxy Retinoic Acid
维甲酸杂质

A metabolite of all-trans retinoic acid
GC18527 4'-hydroxy Flurbiprofen
4-羟基氟吡洛芬
A major active metabolite of flurbiprofen
GC18522 Phosphatidylserines (sodium salt)
L-α-磷脂酰丝氨酸（钠盐）,L-α-Phosphatidylserine
A mixture of phosphatidylserines isolated from soy
GC18517 Diapocynin An inhibitor of NADPH-oxidase
GC18515 8-iso Prostaglandin F2α
8-异前列腺素F2α
An isoprostane that inhibits platelet aggregation
GC18510 Siccanin
西卡宁
An inhibitor of mitochondrial complex II
GC18480 CAY10649 A direct inhibitor of 5-LO product formation
GC18476 Biotin-VAD-FMK A biotin-conjugated pan-caspase inhibitor
GC18471 DG-051 An LTA₄ hydrolase inhibitor
GC18466 5,6-epoxy-13-cis Retinoic Acid
异维A酸EP杂质G
A metabolite of 13-cis retinoic acid
GC18455 Digoxigenin Monodigitoxoside
地高辛杂质D
A Na⁺/K⁺-ATPase inhibitor
GC18452 3,4-Dichloroisocoumarin
3,4-DCI

A serine protease inhibitor