Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC13216 trans-trans Muconic acid
反式,反式-1,3-丁二烯-1,4-二羧酸
trans-trans Muconic acid 是一种苯的尿代谢物，已被用作人体接触苯的生物标志物。
GC10577 trans-Aconitic acid
反式乌头酸
反式乌头酸存在于正常人的尿液中，并且有人建议在雷氏综合征和有机酸尿症中存在大量的乌头酸。
GC15457 Pyridoxine
吡哆醇; Pyridoxol
A 4-methanol form of vitamin B₆
GC15994 Pyridoxal hydrochloride
吡哆醛盐酸盐
A transport form of vitamin B₆
GC10084 Pyridoxal 5 phosphate
磷酸吡哆醛; Pyridoxal 5′-phosphate; Pyridoxyl phosphate
An enzyme cofactor
GC13749 O-Phosphorylethanolamine
乙醇胺磷酸酯,Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
A phospholipid metabolite
GC11828 N-carbamoyl-DL-aspartic acid
脲基琥珀酸; Ureidosuccinic Acid
An intermediate in pyrimidine biosynthesis
GC15129 N-Acetylneuraminic acid
唾液酸; NANA; Lactaminic acid
An abundant sialic acid
GC17521 N-acetyl D-galactosamine
N-乙酰-D-半乳糖胺
An amino sugar derivative of galactose
GC10292 myo-Inositol
肌醇; myo-Inositol; meso-Inositol
肌醇是一种化合物，许多食物中都含有相关的脂质，特别是水果，尤其是哈密瓜和橙子。
GC10631 Melibiose
蜜二糖
蜜二糖是一种二糖，由一个半乳糖和一个葡萄糖部分组成的 α (1-6) 糖苷键。
GC17814 L-Sorbose
L-山梨糖
A monosaccharide
GC10353 L-homocystine
L-高胱氨酸
L-同型半胱氨酸是 L-同型半胱氨酸的氧化成员。
GC12518 L-Dihydroorotic acid
L-氢化乳清酸
L-二氢乳清酸可以通过二氢乳清酶可逆地水解产生无环L-脲基琥珀酸。
GC10730 L-Arabitol
L-(-)-阿拉伯糖醇
L-Arabitol 是红薯、鹿莓、蛾豆等食品消耗的潜在生物标志物，还与阿尔茨海默病和 5-磷酸核糖异构酶缺乏症有关。
GC13084 Ketoisovaleric acid
3-甲基-2-氧丁酸
Ketoisovaleric acid（KIV）是亮氨酸和缬氨酸合成的前体。
GC12809 Itaconic acid
衣康酸
Itaconic acid是一种不饱和二羧酸，可由原核生物和真菌合成，也可在哺乳动物巨噬细胞感染过程中由乌头酸脱羧酶1（ACOD1，也称为IRG1）产生和分泌。
GC16949 Guanine
鸟嘌呤
A purine base
GC15388 Glyoxylic acid
乙醛酸,NSC 27785; Formylformic acid; Oxalaldehydic acid

乙醛酸 (NSC 27785) 是一种既是醛又是羧酸的有机化合物。
GC17170 gamma-Glu-Cys
G-谷氨酸-半胱氨酸,γ-Glutamylcysteine
γ-Glu-Cys (γ-Glutamylcysteine) 是一种含有半胱氨酸和谷氨酸的二肽，是谷胱甘肽 (GSH) 的前体。
GC14331 Folinic acid
亚叶酸; leucovorin
亚叶酸 (Leucovorin) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂给药，以降低 MTX 诱导的毒性。
GC13392 Flavin adenine dinucleotide
黄素腺嘌呤二核苷酸; FAD
黄素腺嘌呤二核苷酸 (FAD) 是一种氧化还原辅助因子，更具体地说是蛋白质的辅基，参与代谢中的几个重要酶促反应。
GC13531 Deoxyadenosine 5-triphosphate
2'-脱氧腺苷5'-三磷酸酯,dATP
脱氧腺苷 5-三磷酸 (dATP) 是细胞中用于 DNA 合成（或复制）的核苷酸，作为 DNA 聚合酶的底物。
GC16449 Cellobiose
D-纤维二糖
A disaccharide
GC16971 β-Nicotinamide mononucleotide
烟酰胺单核苷酸; β-NM; NMN
β-烟酰胺单核苷酸是烟酰胺磷酸核糖转移酶（NAMPT）反应的产物，也是关键的NAD+中间体。
GC17558 Adenosine 5'-triphosphate disodium salt hydrate
腺苷5'-三磷酸二钠盐水合物,Adenosine 5'-triphosphate disodium salt hydrate

Adenosine 5'-triphosphate disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) 是体内能量储存和代谢的核心成分，提供代谢能量以驱动代谢泵，并作为细胞中的辅酶。
GC13172 Adenosine 5-monophosphate
腺苷酸; AMP
5-单磷酸腺苷是调节能量稳态和信号转导的关键细胞代谢物。
GC10880 cAMP (Standard)
Synonyms: 环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; Cyclic AMP; Adenosine 3-5-cyclic monophosphate
A second messenger
GC10067 6-Hydroxynicotinic acid
6-羟基烟酸
6-羟基烟酸是一种内源性代谢物。
GC11270 4-Hydroxybenzoic acid
对羟基苯甲酸
A phenolic acid
GC10996 4-Aminobenzoic acid
对氨基苯甲酸; PABA; Vitamin Bx; Vitamin H1; p-Aminobenzoic acid
A biosynthetic intermediate
GC16812 3-Methylglutaric acid
3-甲基戊二酸
A metabolite of L-leucine
GC14549 3-Hydroxyphenylacetic acid
3-羟基苯乙酸
A phenolic acid with diverse biological activities
GC13571 2-Deoxyuridine
2'-脱氧尿苷; 2-脱氧尿苷
A pyrimidine nucleoside
GC11581 2-Deoxyinosine
2'-脱氧肌苷
A nucleoside form of hypoxanthine
GC12850 2-Deoxy-D-ribose
2-脱氧-D-核糖
A reducing sugar
GC17436 2'-Deoxycytidine-5'-monophosphoric acid
2'-脱氧胞苷-5'-单磷酸
A deoxyribonucleotide
GC17478 2-Deoxycytidine
2'-脱氧胞苷; Deoxycytidine; Cytosine deoxyriboside; Deoxyribose cytidine
A deoxyribonucleoside
GC11642 2-Deoxyadenosine
2'-脱氧腺苷
2-Deoxyadenosine 是一种核苷腺苷衍生物，与双链 DNA 中的脱氧胸苷 (T) 配对。
GC12964 2-3-Dihydroxybenzoic acid
2,3-二羟基苯甲酸; Catecholcarboxylic acid; NSC 27435
2-3-二羟基苯甲酸是一种在血浆中发现的正常人体苯甲酸代谢物，在服用阿司匹林后水平会升高。
GC10156 o-Phenanthroline
1,10-菲罗啉
o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂，可防止在链脲佐菌素处理的细胞中诱导染色体畸变。
GC11553 2-cyano-Pyrimidine
2-氰基嘧啶
A cathepsin K inhibitor
GC14411 Apoptozole
Apoptosis Activator VII
An inhibitor of Hsp70
GC10572 Equisetin
尹奎色亭
An HIV-1 integrase inhibitor
GC13877 1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol
GC10149 cis-ACCP A matrix metalloproteinase inhibitor
GC16375 (±)-Jasmonic Acid methyl ester
甲基茉莉酮酸酯,(±)-Methyl Jasmonate
A plant growth regulator
GC13421 UCF 101 An Omi/HtrA2 protease inhibitor
GC11988 15-acetoxy Scirpenol
15-乙酰蛇形菌素
A trichothecene mycotoxin
GC10661 Destruxin B
黑僵菌素 B
An insecticidal mycotoxin