Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC10265 Manumycin A
手霉素A
A farnesyltransferase inhibitor with antitumor activity
GC13312 HZ-1157
5-叔丁氧基-2,4-二氨基喹唑啉
An HCV NS3/4A protease and Dengue virus inhibitor
GC16536 Phenyl sulfate
GC10016 NCT-501 A reversible inhibitor of ALDH1A1
GC17342 Beauvericin
白僵菌素
白僵菌素（Beauvericin）是一种环状十六缩酚肽霉菌毒素，是酰基辅酶 A：胆固醇酰基转移酶 1（ACAT1）的有效抑制剂，参与多种肿瘤相关途径。
GC17425 Sodium Tauroursodeoxycholate (TUDC)
牛磺熊去氧胆酸钠; Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium
Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达，例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。
GC13958 BPTES An allosteric inhibitor of GLS1
GC17702 K-Ras(G12C) inhibitor 9 An allosteric inhibitor of oncogenic K-Ras(G12C)
GC15161 Calcium D-Panthotenate
泛酸钙; Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt
D-泛酸钙（维生素B5钙盐）是一种维生素，可以降低苹果汁中棒曲霉素的含量。
GC13955 Enoxolone
甘草次酸
An anti-inflammatory and immunomodulatory compound
GC15206 DC_AC50 An inhibitor of Atox1 and CCS
GC17901 Tamoxifen
他莫昔芬; ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。
GC17417 SBC-115076
An inhibitor of PCSK9 action
GC12387 Tiplaxtinin(PAI-039)
ALPHA-氧代-1-(苯基甲基)-5-[4-(三氟甲氧基)苯基]-1H-吲哚-3-乙酸,PAI-039; Tiplasinin
A PAI-1 inhibitor
GC13307 PU-WS13 PU-WS13是一种嘌呤支架类Grp94特异性热休克蛋白90（Hsp90）抑制剂。
GC17012 MK3102
奥格列汀（MK-3102）,MK-3102
MK3102 (Omarigliptin)是一种新型的每周一次的二肽基肽酶-4 (DPP-4)抑制剂(IC50: 2.2 nM)，用于治疗2型糖尿病。
GC14057 GSK1349572 sodiuM salt
度鲁特韦钠盐; S/GSK1349572 sodium
GSK1349572 sodiuM salt (S/GSK1349572 sodium) 是一种高效的口服生物可利用的 HIV 整合酶链转移抑制剂，对 HIV-1 整合酶催化的链转移的 IC50 为 2.7 nM。
GC10485 Mutant IDH1-IN-1 An inhibitor of mutant IDH1
GC11930 KNK437
Heat Shock Protein Inhibitor I
Prevents the synthesis of inducible heat shock proteins
GC16310 FTI 277 HCl FTI 277 HCl 是法尼基转移酶 (FTase) 的抑制剂；一种高效的 Ras CAAX 肽模拟物，可拮抗 H-和 K-Ras 致癌信号传导。
GC13293 LP533401 hcl An inhibitor of gut-derived serotonin biosynthesis
GC14441 SW033291
2-(丁基亚磺酰基)-4-苯基-6-(2-噻吩基)噻吩并[2,3-B]吡啶-3-胺
A potent inhibitor of 15-PGDH
GC11547 MI-773 (SAR405838)
MI-77301
An inhibitor of MDM2-p53 protein-protein interactions
GC17242 (-)-epigallocatechin
(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
A green tea polyphenol
GC17942 Darunavir Ethanolate
达芦那韦乙醇; TMC114 Ethanolate
An HIV-1 protease inhibitor
GC16257 AZD 3988
反式-4-[4-[[[5-[(3,4-二氟苯基)氨基]-1,3,4-恶二唑-2-基]羰基]氨基]苯基]环己烷乙酸
AZD 3988 是一种具有口服活性的 diacylglycerol acyl transferase-1 (DGAT-1) 抑制剂。
GC13464 GSK 2837808A GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。
GC10902 CVT 10216
3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸
A selective, reversible ALDH2 inhibitor
GC14776 EC 144 EC 144 是一种有效的选择性热休克蛋白 90 (Hsp90) 抑制剂，IC50 为 1.1 nM。 EC 144 抑制肿瘤生长并导致部分肿瘤消退。 EC 144 具有研究癌症疾病的潜力。
GC15896 Z-Ile-Leu-aldehyde
Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。
GC11784 LCZ696
沙库必曲/缬沙坦; LCZ696
A dual angiotensin II receptor antagonist and neprilysin inhibitor
GC15227 CB-839
Telaglenastat
Telaglenastat (CB-839) 是一流的、可逆的和具有口服生物利用度的谷氨酰胺酶 1 (GLS1) 抑制剂。
GC11973 HSP990 (NVP-HSP990)
HSP-990
An Hsp90 inhibitor
GC14188 Z-YVAD-FMK Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性 caspase-1 和 -4 抑制剂。
GC16577 SB-3CT
Matrix Metalloproteinase-2/9 Inhibitor IV, MMP-2/MMP-9 Inhibitor IV
A selective inhibitor of MMP-2 and MMP-9
GC16768 Phosphoramidon Disodium Salt
磷酰胺二钠
An inhibitor of NEP and NEP2
GC11894 BMS 309403
Adipocyte FABP Inhibitor, AFABP Inhibitor, ALBP Inhibitor, aP2 Inhibitor, FABP4 Inhibitor, Fatty Acid Binding Protein 4 Inhibitor
A cell-permeable, potent, and selective inhibitor of FABP4
GC15036 Raltegravir potassium salt
雷特格韦钾盐; MK 0518 potassium
An HIV-1 integrase inhibitor
GC11445 YH239-EE A prodrug form of YH 239
GC10881 Gedunin
葛杜宁
A natural inhibitor of p23 A natural inhibitor of p23
GC10940 PRT 4165
NSC600157
An inhibitor of PRC1 ubiquitin ligases
GC12360 UAMC 00039 dihydrochloride A potent DPP-2 inhibitor
GC17751 MKT 077
FJ-776
An Hsp70 inhibitor
GC16597 Alda 1
N-(1,3-苯并二氧杂环戊烯-5-基甲基)-2,6-二氯苯甲酰胺

A selective ALDH2 agonist
GC15234 PF 429242
4-[(二乙基氨基)甲基]-N-[2-(2-甲氧基苯基)乙基]-N-(3R)-3-吡咯烷基苯甲酰胺
A site-1 protease inhibitor
GC16471 Y-29794 oxalate
Inhibitor of prolyl endopeptidase
GC14328 FCCP
碳酰氰-4-三氟甲氧基苯腙,Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
FCCP是一种质子载体（H+离子载体），也是一种强磷酸化解偶联剂，促进质膜和线粒体膜的去极化。
GC11869 SZL P1-41 SZL P1-41是一种特异性S期激酶相关蛋白2（Skp2）抑制剂。
GC16434 TC-E 5006 γ-secretase modulator
GC12395 (D)-(+)-Neopterin
新蝶呤,D-(+)-Neopterin; D-erythro-Neopterin
A biochemical tool to screen for immune disorders