Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC14055 Vanillin
香兰素; p-Vanillin; m-Methoxy-p-hydroxybenzaldehyde; p-Hydroxy-m-methoxybenzaldehyde
An Analytical Reference Standard
GC17902 Inosine
肌苷
A purine nucleoside
GC10199 Hypoxanthine
次黄嘌呤; Purin-6-ol; Sarcine
An endogenous purine derivative
GC16368 Indole-3-carbinol
3-吲哚甲醇; I3C; 3-Indolemethanol
A natural phytochemical
GC12411 RHC 80267
1,6-双(环己基脒基羰基氨基)己烷,U-57908
An inhibitor of DAGL
GC10829 Heparin
肝素
肝素是一种高度硫酸化的糖胺聚糖，被广泛用作注射用抗凝剂，在任何已知生物分子中具有最高的负电荷密度。
GC15708 Cysteine Protease inhibitor hydrochloride
半胱氨酸蛋白酶抑制剂 (盐酸盐)
Cysteine Protease inhibitor hydrochloride 是半胱氨酸蛋白酶的抑制剂。
GC13556 VER-49009
CCT 129397
An Hsp90 inhibitor
GC10501 VER-50589 Inhibitor of Hsp90
GC13434 CP-640186 An ACC inhibitor
GC13726 TRO 19622
奥利索西,TRO 19622; NSC 21311
A mitochondrial-targeted neuroprotective agent
GC13952 Trandolapril
群多普利; RU44570
A prodrug form of trandolaprilat
GC12917 Acetaminophen
对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

An analgesic and antipyretic compound
GC11513 Zofenopril calcium
佐芬普利钙,SQ26991
A prodrug form of zofenoprilat
GC11344 Eicosapentaenoic Acid
二十碳五烯酸; EPA; Timnodonic acid
Eicosapentaenoic Acid（EPA）二十碳五烯酸是一种具有口服活性的omega-3（ω-3）长链多不饱和脂肪酸（PUFA），是前列腺素3、血栓素3和白三烯5类二十烷酸的前体。
GC10451 U-73122
1-[6-[((17Β)-3-雌酮-1,3,5[10]-三烯-17-基)氨基]乙基]-1H-吡咯-2,5-二酮
U-73122是有效的、选择性的磷脂酶C（PLC）抑制剂，IC₅₀值约为1-2.1µM，也可抑制5-脂氧合酶（5-LO）。
GC10977 Methylcobalamin
甲钴胺; CH3-B12
An analog of vitamin B₁₂
GC11272 Phenylephrine HCl
盐酸去氧肾上腺素; (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride
Phenylephrine HCl（盐酸去氧肾上腺素）是一种选择性的α1-肾上腺素能受体激动剂。
GC13742 Uridine
尿苷; β-Uridine
A pyrimidine nucleoside
GC14142 Acetylcholine Chloride
氯化乙酰胆碱; ACh chloride
A neurotransmitter
GC18002 Vitamin B12
维生素B12; Cyanocobalamin
A corrinoid vitamin
GC12256 D-Mannitol
D-甘露醇 ; Mannitol; Mannite
An Analytical Reference Standard
GC14573 Xylose
DL-木糖; (±)-Xylos
木糖是有机合成的中间体。
GC11655 Moexipril HCl
莫昔普利盐酸盐,RS-10085
A prodrug form of moexiprilat
GC12368 Quinapril HCl
盐酸喹那普利,CI-906
A prodrug form of quinaprilat
GC12974 Medroxyprogesterone acetate
醋酸甲羟孕酮; Medroxyprogesterone 17-acetate; Farlutin
Medroxyprogesterone acetate（MPA）是一种人工合成的孕激素。
GC17034 Temocapril HCl
盐酸替莫普利
A prodrug form of temocaprilat
GC17667 Cilazapril Monohydrate
西拉普利水合物; Ro 31-2848 monohydrate
A prodrug form of cilazaprilat
GC16307 Lisinopril
赖诺普利; MK-521
An ACE inhibitor
GC17216 NAD+
烟酰胺腺嘌呤双核苷酸
NAD+是一种转递氢离子的辅酶，参与许多酶促反应，由核糖基烟酰胺5'-二磷酸通过焦磷酸键与5'-磷酸腺苷偶联组成。
GC10142 Enalapril Maleate
马来酸依那普利; MK-421 maleate
An ACE inhibitor
GC10091 Nateglinide
那格列奈; A4166; Senaglinide
A hypoglycemic agent
GC15405 Riboflavin (Vitamin B2)
维生素B2,Vitamin B2; E101
核黄素（维生素 B2）是一种易于吸收的微量营养素，在维持人类和其他动物的健康方面发挥着关键作用。
GC11532 Lonidamine
氯尼达明; AF-1890; Diclondazolic Acid; DICA
An inhibitor of hexokinase
GC14098 Menadione
维生素K3; Vitamin K3
A provitamin
GC11029 Isoprenaline HCl
盐酸异丙肾上腺素; Isoproterenol hydrochloride

A β₁- and β₂-AR agonist
GC17278 Adenine sulfate
硫酸腺嘌呤; 6-Aminopurine hemisulfate; Vitamin B4 hemisulfate
A purine base
GC15509 Uracil
尿嘧啶
A pyrimidine nucleoside
GC15184 Taurine
牛磺酸; 2-Aminoethanesulfonic acid
A sulfur-containing amino acid
GC12715 Synephrine HCl
辛弗林盐酸盐; Oxedrine hydrochloride
An alkaloid
GC10278 Sucralose
三氯蔗糖; E955; Trichlorosucrose
A synthetic disaccharide and non-caloric sweetener
GC15502 Gluconate sodium
葡萄糖酸钠; D-Gluconic acid sodium salt; Sodium D-gluconate; D-Gluconate sodium salt
葡萄糖酸钠（D-葡萄糖酸钠盐）是普通钢在模拟冷却水中的缓蚀阻垢剂。
GC14843 Serotonin HCl
5-羟基色胺盐酸盐; 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride

Serotonin HCl是一种神经递质，是介导人体多种中枢和外周功能的关键信使。
GC18016 Salicylanilide
水杨酰苯胺,2-Hydroxybenzanilide
Salicylanilide 具有广泛的生物活性，包括抗病毒效力，可通过靶向 HIV-1 整合酶或逆转录酶来抑制 HIV 病毒。
GC15755 Ribitol
核糖醇; Adonitol; Adonite
A pentose sugar alcohol
GC17393 Pyridoxine HCl
吡哆醇盐酸盐; Pyridoxol hydrochloride; Vitamin B6 hydrochloride
A 4-methanol form of vitamin B₆
GC10675 (+,-)-Octopamine HCl
章胺盐酸盐; (±)-p-Octopamine hydrochloride
An endogenous biogenic amine
GC12182 Estriol
雌三醇; Oestriol
An estradiol metabolite produced during pregnancy
GC18075 Erythritol
赤藓糖醇
赤藓糖醇是一种糖醇，天然存在于各种食物中（例如。
GC16292 Equol
(±)-雌马酚
An estrogen receptor agonist