Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC13072 Epiandrosterone
表雄酮; 3β-Androsterone; trans-Androsterone; iso-Androsterone
An Analytical Reference Standard
GC16192 Diminazene Aceturate
4,4’-二脒基重氮氨基苯二乙尿酸
An anti-protozoal diamidine
GC12349 Deoxycorticosterone acetate
醋酸去氧皮质酮; 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate
A corticosteroid
GC16079 Deoxyarbutin
脱氧熊果苷
A tyrosinase inhibitor
GC13502 Cysteamine HCl
半胱胺盐酸盐; 2-Aminoethanethiol hydrochloride; 2-Mercaptoethylamine hydrochloride
A radioprotective aminothiol
GC11872 Creatinine
肌酸酐; NSC13123
The end product of the creatine-creatine phosphate energy shuttle
GC17398 Cholesterol
胆固醇

A sterol
GC16181 Cathepsin Inhibitor 1 Cathepsin inhibitor 1 (compound 25) 是一种有效的选择性 Cathepsin 抑制剂，对 CatL、CatL2、CatS、CatK 和 CatB 的 pIC50 分别为 7.9、6.7、6.0、5.5 和 5.2。
GC14930 Benzbromarone
苯溴马隆
An inhibitor of URAT1
GC11843 Azaguanine-8
8-氮鸟嘌呤; 8-AG
Azaguanine-8 是一种嘌呤类似物，具有抗肿瘤活性。 Azaguanine-8 起抗代谢物的作用，很容易与核糖核酸结合，干扰正常的生物合成途径，从而抑制细胞生长。
GC16443 4-Aminohippuric Acid
对氨基马尿酸; p-Aminohippuric acid
A substrate for OAT1, NPT1, and MDR2
GC17829 1-Hexadecanol
鲸蜡醇
鲸蜡醇（1-Hexadecanol）是一种合成的固体脂肪醇和非离子表面活性剂，是一种亲脂性底物，鲸蜡醇在药物制剂中用作乳化剂。
GC11551 Hydrocortisone
氢化可的松; Cortisol
氢化可的松是一种由肾上腺和肾上腺外组织分泌的天然糖皮质激素，通过与其同源糖皮质激素受体 (GR) 结合，局部控制参与炎症、免疫反应、新陈代谢和能量稳态的基因的转录。
GC11528 Orotic acid
乳清酸; 6-Carboxyuracil; Vitamin B13
乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。
GC15760 Ramipril
雷米普利; HOE-498
A prodrug from of ramiprilat
GC15493 Enalaprilat Dihydrate
2,4-二氯苯基-2-(-1H-咪唑)乙醇
The active metabolite of an ACE inhibitor
GC14106 Adenosine
腺苷; Adenine riboside; D-Adenosine
A purine nucleoside
GC17362 Metolazone
美托拉宗; SR-720-22
A thiazide-like diuretic
GC16290 Nafamostat hydrochloride
盐酸萘莫司他
Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。
GC17676 Nafamostat
萘莫司他
A serine protease inhibitor
GC16508 Salicylic acid
水杨酸; 2-Hydroxybenzoic acid
An Analytical Reference Standard
GC13729 Cytidine
胞苷; Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside
A pyrimidine nucleoside
GC13432 Adenine
腺嘌呤; 6-Aminopurine; Vitamin B4
腺嘌呤（6-氨基嘌呤）是一种嘌呤，是DNA核酸中的四种核碱基之一。腺嘌呤是DNA和RNA的化学成分。腺嘌呤还在涉及细胞呼吸、ATP 和辅因子（NAD 和 FAD）的形式以及蛋白质合成的生物化学中发挥重要作用。
GC12920 Pregnenolone
孕烯醇酮; 3β-Hydroxy-5-pregnen-20-one
A natural steroid hormone
GC13206 Nicotinic Acid
烟酸; Nicotinic acid; Vitamin B3
烟酸（维生素 B3）是一种具有口服活性的水溶性维生素 B3，是人体必需的营养素。
GC17347 Alprostadil
前列地尔; Alprostadil; PGE1;Prostaglandin E1
前列地尔Alprostadil作为前列腺素受体配体,对小鼠EP3、EP4、EP2、IP和EP1的结合亲和Kis分别为1.1 nM、2.1 nM、10 nM、33 nM和36 nM。
GC16871 Perindopril
培哚普利; S-9490
An orally active ACE inhibitor
GC17941 Benazepril HCl
盐酸贝那普利; CGS14824A
A prodrug of benazeprilat
GC11228 Benazepril
贝那普利
贝那普利，一种血管紧张素转换酶抑制剂，是一种用于治疗高血压的药物。
GC17985 Chenodeoxycholic Acid
鹅去氧胆酸
A primary bile acid
GC15086 MLN4924
氨基磺酸[(1S,2S,4R)-4-[4-[[(1S)-2,3-二氢-1H-茚-1-基]氨基]-7H-吡咯并[2,3-D]嘧啶-7-基]-2-羟基环戊基]甲基酯,MLN4924
MLN4924 是一种有效的选择性 NEDD8 激活酶 (NAE) 小分子抑制剂 (IC50 = 4 nM) ，并且相对于密切相关的酶 UAE、SAE、UBA6 和 ATG7 具有选择性（ IC50 = 1.5、8.2、1.8 和 >；分别为 10 μM）。
GC16066 Calcifediol
25-羟基维生素 D3; 25-hydroxy Vitamin D3
A vitamin D intermediate
GC11268 L-Thyroxine
L-甲状腺素,Levothyroxine; T4
A synthetic form of thyroxine
GC12123 sn-Glycero-3-phosphocholine
甘磷酸胆碱; Choline Alfoscerate; Alpha-GPC; L-α-GPC
A nootropic phospholipid
GC12301 Mizoribine
咪唑立宾; NSC 289637; HE 69
An imidazole nucleoside with immunosuppressive properties
GC16772 Cortisone acetate
醋酸可的松; Cortisone 21-acetate
A synthetic glucocorticoid
GC17017 Racecadotril
消旋卡多曲; Acetorphan
An enkephalinase inhibitor
GC14785 Alvelestat
AZD9668
An inhibitor of neutrophil elastase
GC10146 AHU-377(Sacubitril)
沙库必曲; AHU-377
A prodrug form of LBQ657
GC10667 Vitamin D3
维生素D3; Cholecalciferol; Colecalciferol
A precursor to calcitriol
GC17709 Nelfinavir
甲磺酸萘非那韦,AG1341
Nelfinavir Mesylate 是强效的HIV protease抑制剂，Ki为2 nM。
GC16127 Topiroxostat
托匹司他; FYX-051
An inhibitor of xanthine oxidoreductase
GC10956 Imeglimin hydrochloride
(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐,EMD 387008 hydrochloride
Imeglimin hydrochloride (EMD 387008) 是一种口服降糖剂。
GC10576 Imeglimin
EMD 387008
Imeglimin (EMD 387008) 是一种口服降糖剂。
GC11070 Dehydroepiandrosterone (DHEA)
脱氢表雄酮; Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone
脱氢表雄酮 (DHEA) 及其硫酸酯 DHEAS 共同代表了人体内最丰富的类固醇激素。
GC13161 Escitalopram
艾司西酞普兰; (S)-Citalopram; (S)-(+)-Citalopram
A selective serotonin reuptake inhibitor
GC14435 Zileuton sodium
齐留通钠盐; A 64077 sodium; Abbott 64077 sodium
A reversible inhibitor of 5-lipoxygenase
GC13363 Ursodiol
熊去氧胆酸; Ursodeoxycholate; Ursodiol; UDCA
Ursodiol（UDCA）是一种微生物通过初级胆汁酸鹅去氧胆酸（CDCA）的7α/β 异构化转化而来的次级胆汁酸。Ursodiol可用于多种肝脏疾病和胃肠道疾病的研究。
GC11669 Tamoxifen Citrate
他莫昔芬柠檬酸盐; ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate
A selective estrogen receptor modulator
GC17801 PYZD-4409 PYZD-4409 是泛素激活酶 UBA1 的特异性抑制剂，IC50 为 20 μM（无细胞酶测定）。 PYZD-4409 在恶性细胞中诱导细胞死亡并优先抑制原发性急性髓细胞白血病细胞的克隆形成。