Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC19630 Adenosine 2′-monophosphate
腺苷-2'-一磷酸,2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate
腺苷 &2#8242;-一磷酸 (2'-AMP) 被细胞外 2',3'-CAMP 转化。
GC19626 Cyclic AMP
环磷腺苷; Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP
环磷酸腺苷（Cyclic AMP; cAMP）是三磷酸腺苷的衍生物，是第一个被鉴定出的第二信使，将信号从受体传播到下游途径。
GC19608 Putrescine
四亚甲基二胺,Putrescine; NSC 60545; Putramine
Putrescine腐胺(多胺、亚精胺和精胺)是一种低分子量的有机阳离子，它们在细胞生长、细胞分化、调节酶活性、调节离子通道以及控制DNA和蛋白质合成等方面具有重要作用。
GC14816 L-Adrenaline
肾上腺素,L(-)-Epinephrine
An adrenergic receptor agonist
GC19539 2-Pyrrolidinone
2-吡咯烷酮,2-Pyrrolidone
GC19528 1,4-Benzoquinone
对苯醌
A toxic metabolite of benzene
GC19134 beta-D-(-)-Arabinose
D-阿拉伯糖
A monosaccharide
GC48948 α-Ketoglutaric Acid (sodium salt)
LPHA-酮戊二酸钠(2-8℃),Alpha-Ketoglutaric acid Sodium
An intermediate in the citric acid cycle
GC48924 TFM
3-三氟甲基-4-硝基苯酚
A piscicide
GC48894 SIH
2-异丙基噻吨酮
An iron chelator
GC48893 Carbazomycin B A bacterial metabolite with diverse biological activities
GC48850 Carbazomycin C A bacterial metabolite with diverse biological activities
GC48804 N-desmethyl Olanzapine
N-去甲基奥氮平
A major metabolite of olanzapine
GC48739 (±)15-HETE-d8
(±)15-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15-HETE
GC48738 (±)12-HETE-d8
(±)12-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 12-HETE
GC48721 6-O-Demethyl Griseofulvin
6-Demethylgriseofulvin
A metabolite of griseofulvin
GC48720 Griseofulvic Acid
(±)-Griseofulvic Acid
A metabolite of griseofulvin
GC48659 Umbelliprenin
7-Farnesyloxycoumarin
A prenylated coumarin with diverse biological activities
GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine
GC48611 Ambroxol-d5
盐酸氨溴索D5
An internal standard for the quantification of ambroxol
GC48547 Sartorypyrone D A fungal metabolite
GC48528 Piericidin B A bacterial metabolite with insecticidal and antimicrobial activities
GC48526 MXS A fluorescent probe for hypochlorous acid
GC48509 Apigenin 7-O-Glucuronide (hydrate) Apigenin 7-O-glucuronide is a flavonoid that has been found in J
GC48493 PCI 45227
依鲁替尼代谢物,PCI-45227
An active metabolite of ibrutinib
GC48464 GC376 (sodium salt) An inhibitor of 3C- and 3C-like proteases
GC48461 rac-trans-4-hydroxy Glyburide
4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide
An active metabolite of glyburide
GC48457 3-keto Fusidic Acid
3-酮基夫西地酸(欧洲药典标准品)
An active metabolite of fusidic acid
GC48440 2'-Deoxycytidine-5'-triphosphate (sodium salt)
2'-脱氧胞苷-5'-三磷酸三钠盐,dCTP trisodium salt; 2′-Deoxycytidine-5′-triphosphate trisodium salt
A nucleoside triphosphate
GC48430 Ac-DEVD-CMK (trifluoroacetate salt)
AcAspGluValAspCMK, Caspase3 Inhibitor III
An inhibitor of caspase-3
GC48425 C18 D-threo Ceramide (d18:1/18:0)
D-threo Cer(d18:1/18:0), D-threo Ceramide (d18:1/18:0), N-octadecanoyl-D-threo-Sphingosine, N-stearoyl-D-threo-Sphingosine
A synthetic ceramide
GC48421 GW 280264X
((S)-5-((2R,3S)-3-(N-羟基甲酰胺基)-2-异丁基六氨基)-2-氧代-6-(噻唑-2-基氨基)己基)氨基甲酸苄酯
An ADAM17/TACE and ADAM10 inhibitor
GC48416 Chlorhexidine-d8 (hydrochloride)
CHX-d8
An internal standard for the quantification of chlorhexidine
GC48399 MTP 131 (acetate)
Elamipretide, SS-31
A mitochondria-targeted peptide antioxidant
GC48398 WST-1
2-(4-碘苯)-3-(4-硝基苯)-5-(2,4-二磺基苯)-2H-四氮唑钠盐
A water-soluble and cell-permeable tetrazolium dye
GC19584 Alkaline Phosphatase
碱性磷酸酯酶

10-50units/mg protein(37℃,pH 9.8)
GC50653 SBP1-FITC Fluorescently labelled peptide derived from human ACE2 (SBP1)
GC50650 SBP1 Human ACE2 receptor-derived 23-amino acid peptide
GC19572 Catechol
邻苯二酚
A polyphenol
GC19569 Hydroquinone
1,4-苯二酚,Quinol
GC48267 Zileuton-d4
齐留通 d4
An internal standard for the quantification of zileuton
GC48250 Vildagliptin-d7
维格列汀D7,LAF237-d7; NVP-LAF 237-d7
An internal standard for the quantification of vildagliptin
GC48200 Trelagliptin-13C-d3 A neuropeptide with diverse biological activities
GC48192 trans-2-Octenoyl-L-carnitine
CAR 8:1, C8:1 Carnitine, L-Carnitine trans-2-octenoyl ester, L-trans-2-Octenoylcarnitine
A synthetic carnitine
GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
GC48136 Telaprevir-d4
VX-950-d4
A neuropeptide with diverse biological activities
GC48124 Tamoxifen-d5
ICI 47699-?d5; (Z)-Tamoxifen-?d5; trans-Tamoxifen-?d5
An internal standard for the quantification of tamoxifen
GC48107 Stearoyl-L-carnitine-d3 (chloride)
CAR 18:0-d3, C18:0 Carnitine-d3, L-Carnitine octdecanoyl ester-d3, L-Carnitine stearoyl ester-d3, L-Octadecanoylcarnitine-d3, Octadecanoyl-L-carnitine-d3, L-Stearoylcarnitine-d3, R-Stearoyl carnitine-d3
An internal standard for the quantification of stearoyl-L-carnitine
GC48101 SSAA09E1 A SARS-CoV entry inhibitor
GC48093 Spiromesifen
螺甲螨酯
An insecticide and acaricide