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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC64654 N-Acetyl-α-D-glucosamine 1-phosphate disodium

    N-乙酰-A-D-氨基葡萄糖-1-磷酸酯

     N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) 是一种异位糖磷酸盐，是 N- 糖蛋白生物合成的关键中间体。N-acetyl-α-d-glucosamine 1-phosphate disodium 是细菌细胞壁组分磷胆酸和鼠胺的代谢前体。
  3. GC64653 L-Serine-d3

    L-丝氨酸-D3,(-)-Serine-d3; (S)-Serine-d3

     L-Serine-d3 ((-)-Serine-d3) 是 L-Serine 的氘代物。L-Serine ((-)-Serine; (S)-Serine) 是非必需氨基酸之一，在细胞增殖中起着重要作用。
  4. GC64621 4-Nitrocatechol

    4-硝基儿茶酚

     4-Nitrocatechol 是一种有效的脂氧合酶 (lipoxygenase) 抑制剂。
  5. GC64618 ALDH1A3-IN-3

    4-异丙氧基苯甲醛

     ALDH1A3-IN-3 (化合物 16) 是一种有效的 ALDH1A3 抑制剂，IC50 值为 0.26 μM。ALDH1A3-IN-3 也是 ALDH3A1 的底物。ALDH1A3-IN-3 可用于前列腺癌的研究。
  6. GC64616 Potassium Gluconate

    葡萄糖酸钾; Potassium D-gluconate

     Potassium Gluconate (Potassium D-gluconate) 是一种具有杀菌作用和螯合性质并具有口服活性的氧化型羧酸。
  7. GC64598 1-Methyl-L-histidine-d3

    3-甲基-D3-L-组氨酸

     1-Methyl-L-histidine-d3 是氘标记的 1-Methyl-L-histidine，是肉类摄入和外源性 3-甲基组氨酸 (3MH) 摄入量的客观指标。
  8. GC64597 Spirapril hydrochloride

    盐酸螺普利; SCH 33844 hydrochloride

     Spirapril (SCH 33844) hydrochloride 是一种有效的血管紧张素转换酶 (ACE) 抑制剂，具有降压作用。Spirapril hydrochloride 竞争性地与 ACE 结合，阻止血管紧张素I向血管紧张素 II 的转化。Spirapril hydrochloride 是螺普利拉的一种口服活性前药，可用于高血压、充血性心力衰竭的研究。
  9. GC64535 (S,S)-TAPI-1

    TAPI

     A TACE inhibitor
  10. GC64534 Moveltipril

    莫维普利,Moveltipril calcium; MC-838

     Moveltipril (Moveltipril calcium; MC-838) 是一种有效的血管紧张素转换酶 (ACE) 抑制剂。
  11. GC64531 KCC009 KCC009 是转谷氨酰胺酶 2 的抑制剂，可诱导 p53 途径依赖的放疗敏感性。
  12. GC64511 Hydroxy ritonavir

    羟基利托那韦

     Hydroxy ritonavir 是 Ritonavir 的代谢物。Ritonavir 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。
  13. GC64483 PKR-IN-C51 PKR-IN-C51(compound 51) 是一种 ATP 竞争性双链 RNA 活化蛋白激酶 (PKR) 抑制剂，IC50IC50 为 9 μM。PKR-IN-C51 在原代小鼠巨噬细胞中以剂量依赖性方式抑制细胞内 PKR 活化。
  14. GC64478 L-Aspartic acid-13C4

    L-天门冬氨酸 13C4

     L-Aspartic acid-13C4 是带有 13C 标记的 L-Aspartic acid。L-Aspartic acid 是一种氨基酸，被证明是一种结肠特异性药物输送的前体药物。
  15. GC64473 (S)-3,4-Dihydroxybutyric acid lithium hydrate (S)-3,4-Dihydroxybutyric acid (lithium hydrate) 是一种正常的人体尿液代谢物，在琥珀酸半醛脱氢酶 (SSADH) 缺乏症患者中浓度增加。
  16. GC64471 Glutaric acid-d6

    戊二酸 d6

     Glutaric acid-d6 是 Glutaric acid 的氘代物。Glutaric acid，一种 C5 二羧酸，是赖氨酸和色氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的指标。
  17. GC64469 Ribavirin carboxylic acid

    利巴韦林羧酸

     Ribavirin carboxylic acid (TR-COOH) 是一种 ribavirin 的代谢物 (metabolite)，ribavirin 具有强烈的抗病毒活性。
  18. GC64468 L-Alanine-d4

    氘代丙氨酸,L-2-Aminopropionic acid-d4

     L-Alanine-d4 (L-2-Aminopropionic acid-d4) 是 L-Alanine 的氘代物。L-Alanine 是一种非必需氨基酸，能够参与糖和酸的代谢，增强免疫力，并能为肌肉组织、大脑和中枢神经系统提供能量。
  19. GC64433 L-Tyrosine-d7

    L-酪氨酸 d7

     L-Tyrosine-d7 是 L-Tyrosine 的氘代物。L-Tyrosine 是一种非必需氨基酸，能抑制后部皮层中柠檬酸合成酶的活性。
  20. GC64404 1-Aminopropan-2-ol

    1-氨基-2-丙醇；异丙醇胺

     1-Amino-propan-2-ol 存在于从细菌到人类的所有生物体中， 是一种有鱼腥味的化合物。已检测到 1-氨基-丙-2-醇，但未在几种不同的食物中进行定量，例如鸭科动物 、鸡 和家猪。这可以使 1-amino-propan-2-ol 成为这些食物消费的潜在生物标志物。
  21. GC64384 YC-001 YC-001 是一种非视黄醛化合物，经证实对视杆细胞视蛋白 具有反向激动剂和拮抗剂活性。
  22. GC52105 Montelukast

    孟鲁司特,MK0476 free base

     A CysLT1 receptor antagonist
  23. GC52094 L-Carnitine-d9 (chloride)

    盐酸左卡尼汀:,(R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride

     An internal standard for the quantification of L-carnitine
  24. GC52076 Temozolomide Acid

    3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸

     An active metabolite of temozolomide
  25. GC52074 Loratadine N-oxide

    氯雷他定N-氧化物

     A metabolite of loratadine
  26. GC52060 Trimipramine N-oxide

    10,11-二氢-N,N,BETA-三甲基-5H-二苯并[B,F]氮杂卓-5-丙胺N-氧化物

     An active metabolite of trimipramine
  27. GC52059 AMOZ

    硝基呋喃代谢物AMOZ,3-Amino-5-morpholinomethyl-2-oxazolidone

     A metabolite of furaltadone
  28. GC52054 Ranitidine S-oxide

    雷尼替丁EP杂质C (Ranitidine S-Oxide)

     A metabolite of ranitidine
  29. GC52052 Dofetilide N-oxide

    多非利特氮氧化物,UK-116856

     A metabolite of dofetilide
  30. GC52049 Myricetin 3-galactoside

    杨梅素 3-O-半乳糖苷

     A flavonoid with diverse biological activities
  31. GC52045 N-desmethyl Azelastine

    氮卓斯汀杂质

     An active metabolite of azelastine
  32. GC52035 Esmolol Acid (hydrochloride)

    艾司洛尔酸钠

     An active metabolite of esmolol
  33. GC52033 S-Methyl-D-penicillamine A metabolite of D-penicillamine
  34. GC52029 2-Aminoflubendazole

    2-氨基氟苯咪唑

     A metabolite of flubendazole
  35. GC52024 Aripiprazole N-oxide

    阿立哌唑-N1-氧化物

     A metabolite of aripiprazole
  36. GC52019 Norpropranolol (hydrochloride)

    (±)-Desisopropylpropranolol, N-Desisopropylpropranolol

     An active metabolite of propranolol
  37. GC52007 N-hydroxylamine Dapsone

    羟胺氨苯砜

     An active metabolite of dapsone
  38. GC52005 Triazolomethylindole-3-acetic Acid

    三唑甲基吲哚-3-乙酸

     A metabolite of rizatriptan
  39. GC19941 DL-Leucic Acid
  40. GC49901 BAY-179 A mitochondrial complex I inhibitor
  41. GC49894 15(S)-HETE-d8 ethyl ester

    15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester

     An internal standard for the quantification of 15(S)-HETE ethyl ester
  42. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

    盐酸文拉法辛杂质D

     A minor active metabolite of venlafaxine
  43. GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade)

    10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF

     A formyl donor and cofactor
  44. GC49869 3-Methoxytyrosine

    2-氨基-3-(4-羟基-3-甲氧基苯基)丙酸

     An active metabolite of L-DOPA
  45. GC49866 Desmethyl Carvedilol

    O-去甲卡维地洛

     An active metabolite of carvedilol
  46. GC49863 Cytarabine 5′-monophosphate

    ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

     An active metabolite of cytarabine
  47. GC49858 Desipramine-d4 (hydrochloride)

    盐酸去郁敏D4

     An internal standard for the quantification of desipramine
  48. GC49855 Harmalol (hydrochloride hydrate)

    骆驼蓬酚盐酸盐(二水)

     A β-carboline alkaloid and an active metabolite of harmaline
  49. GC49851 Norquetiapine

    11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓

     An active metabolite of quetiapine
  50. GC49849 3-Aminosalicylic Acid

    3-氨基水杨酸

     A salicylic acid derivative
  51. GC49845 Piribedil N-oxide

    吡贝地尔氮氧化物

     A metabolite of piribedil

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