Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC61181 Phenylpropiolic acid
苯丙炔酸
Phenylpropiolicacid是一种内源性代谢产物。
GC61180 Phenidone
菲尼酮
Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
GC61165 Paeoniflorgenin
芍药苷元
Paeoniflorgenin是Paeoniflorin的去糖基化代谢产物。
GC61164 Oxytetracycline hydrochloride
盐酸土霉素
A broad-spectrum antibiotic
GC61158 ONO-5334 ONO-5334是一种强效、选择性和口服活性的组织蛋白酶K(cathepsinK)抑制剂，对人、兔和大鼠组织蛋白酶K的作用值分别为0.10nM、0.049nM和0.85nM。ONO-5334是一种有效的抗SAR-COV-2病毒活性的抗病毒化合物，其EC50值为500nM。ONO-5334有潜力用于骨质疏松症以及COVID-19的相关研究。
GC61150 O-Desmethylangolensin
O-DMA
A phytoestrogen and an active metabolite of diadzein
GC61147 O-desmethyl Mebeverine acid
美贝维林去甲基苯甲酸,Mebeverine metabolite O-desmethyl Mebeverine acid
A metabolite of mebeverine
GC61145 Octadecanedioic acid
十八烷二酸
Octadecanedioicacid是一种内源性代谢物，一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。
GC61144 Octadecanal
十八烷醛
Octadecanal是一种长链醛，存在于大腿和胸部肌肉中。
GC61137 Nordoxepin D3 hydrochloride
Desmethyldoxepin-d3 hydrochloride
NordoxepinD3hydrochloride(DesmethyldoxepinD3hydrochloride)是Nordoxepinhydrochloride的氘代物。Nordoxepinhydrochloride是Doxepinhydrochloride的活性代谢产物，Doxepinhydrochloride具有口服活性和抗抑郁作用。
GC61130 NHC-triphosphate
NHC-triphosphate是NHC的活性胞内磷酸盐代谢物(intracellularmetabolite)，以三磷酸盐的形式存在。NHC-triphosphate是病毒聚合酶(viralpolymerase)的弱底物替代物，会被并入HCV复制子RNA中。
GC61115 N-Desethyl Oxybutynin D5 hydrochloride N-DesethylOxybutyninD5hydrochloride是N-DesethylOxybutyninhydrochloride的氘代物。N-DesethylOxybutynin是Oxybutynin的活性代谢产物。Oxybutynin是一种抗胆碱能药，抑制电压依赖型K+通道。
GC61107 N-Acetyl-L-glutamic acid
N-乙酰-L-谷氨酸
N-Acetylglutamic acid (N-Acetylglutamate) is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates.
GC61105 N4-Acetylcytidine
N4-乙酰基胞苷
A catabolite of cytidine
GC61103 N,N,O-Tridesmethylvenlafaxine
1-2-氨基-1-(4-羟苯基)乙基环己醇
N,N,O-Tridesmethylvenlafaxine是一种内源性代谢产物。
GC61083 Monomethyl phthalate
邻苯二甲酸单甲酯,2-(Methoxycarbonyl)benzoic acid
Monomethylphthalate是一种邻苯二甲酸代谢物(metabolite)。Monomethylphthalate作为暴露于phthalate后的尿液生物标记物，可作为甲状腺癌和良性结节的检测指标。
GC61081 Monobenzyl phthalate
邻苯二甲酸单苄酯,2-((Benzyloxy)carbonyl)benzoic acid
Monobenzylphthalate(2-((Benzyloxy)carbonyl)benzoicacid)是暴露于邻苯二甲酸盐(如，邻苯二甲酸二乙基己酯)后的尿代谢物(urinarymetabolite)。
GC61057 Methyl p-tert-butylphenylacetate
对叔丁基苯乙酸甲酯
Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour.
GC61056 Methyl phenylacetate
苯乙酸甲酯
Methylphenylacetate是一种内源性代谢产物。
GC61053 Methyl cyclohexanecarboxylate
环己甲酸甲酯
An aliphatic ester
GC61051 Methyl anisate
4-甲氧基苯甲酸甲酯
Methylanisate是一种内源性代谢产物。
GC61050 Methyl acetylacetate
乙酰乙酸甲酯,Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl 3-oxobutyrate; Methyl acetoacetate; Methyl acetylacetate
Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.
GC61049 Methyl 3-phenylpropanoate
3-苯丙酸甲酯
Methyl3-phenylpropanoate是一种内源性代谢产物。
GC61048 Methoxyacetic acid
甲氧基乙酸
Methoxyaceticacid是一种内源性代谢产物。
GC61044 Mesitaldehyde
2,4,6-三甲基苯甲醛; 2,4,6-Trimethylbenzaldehyde
Mesitaldehyde是一种内源性代谢产物。
GC61041 Mepazine hydrochloride
哌卡嗪盐酸盐,Pecazine hydrochloride
Mepazinehydrochloride(Pecazinehydrochloride)是一种有效的选择性MALT1蛋白酶抑制剂。Mepazinehydrochloride抑制全长GSTMALT1和GSTMALT1325-760段的IC50分别为0.83和0.42μM。Mepazinehydrochloride通过增强细胞凋亡(apoptosis)来影响ABC-DLBCL细胞的生存能力。
GC61037 Mebeverine acid
美贝维林盐酸盐,Mebeverine metabolite Mebeverine acid
A metabolite of mebeverine
GC61027 m-Anisaldehyde
3-甲氧基苯甲醛
m-Anisaldehyde是一种内源性代谢产物。
GC61013 Lumisterol 3 (>90%)
光甾醇 3; 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C
A photoisomer of previtamin D₃
GC61007 L-Sepiapterin
L-墨蝶呤,Sepiapterin
L-Sepiapterin(Sepiapterin)是内皮型一氧化氮合酶(eNOS)辅因子四氢生物喋呤(BH4)的前体。L-Sepiapterin改善db/db小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin通过下调p70S6K依赖性VEGFR-2表达抑制卵巢癌细胞增殖和迁移。
GC60999 L-Norvaline
L-正缬氨酸
An inhibitor of arginase and p70S6K1
GC60991 L-Homocysteine
L-高半胱氨酸
A thiol-containing amino acid
GC60979 L-Cysteine hydrochloride hydrate
L-半胱氨酸盐酸盐一水合物
L-cysteine Hydrochloride, also known as L-CYSTEINE or Cysteine HCL (anhydrous), is classified as a cysteine or a cysteine derivative that increases glutathione levels and is important for lung and brain function and liver detoxification.
GC60978 L-Chicoric Acid
L-菊苣酸; (-)-Chicoric acid; trans-Caffeoyltartaric acid
A dicaffeoyl ester with diverse biological activities
GC60976 L-Aspartic aicd sodium
L-天门冬氨酸钠; Sodium L-aspartate
L-Asparticaicdsodium是一种氨基酸，被证明是一种结肠特异性药物输送的前体药物。
GC60960 JPM-OEt JPM-OEt是一种广谱的半胱氨酸组织蛋白酶(cysteinecathepsin)抑制剂。JPM-OEt在活性位点共价结合，并且不可逆地抑制半胱氨酸组织蛋白酶家族。具有抗肿瘤活性。
GC60948 Isohomovanillic acid
3-羟基-4-甲氧基苯乙酸,3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid
Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
GC60947 Isoeuphorbetin
异千金子素；异双七叶内酯
Isoeuphorbetin，一种从Violaphilippica中分离的二聚香豆素，是一种强效HCV蛋白酶(HCVprotease)抑制剂，IC50为3.63µg/mL。
GC60942 Isobutyryl-L-carnitine chloride
L-异丁酰基肉碱
An acylcarnitine
GC60934 Indole-3-methanamine
吲哚-3-甲胺
Indole-3-methanamine是大麦、谷类食物的摄取生物标志物。
GC60933 Imidazol-1-yl-acetic acid
咪唑-1-乙酸
Imidazol-1-yl-aceticacid是一种内源性代谢产物。
GC60920 Hydroxyhexamide
(±)-Hydroxyhexamid
Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.
GC60916 Hydroxyacetone
丙酮醇
Hydroxyacetone是一种内源性代谢产物。
GC60898 H-His-OH.HCl.H2O
L-盐酸组氨酸一水物,H-His-OH.HCl.H2O
L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.
GC60871 Gemigliptin tartrate
吉格列汀酒石酸盐,LC15-0444 tartrate
A DPP-4 inhibitor
GC60861 FTI-2153 FTI-2153是一种有效、高度选择性的法尼基转移酶farnesyltransferase(FTase)抑制剂，IC50为1.4nM。FTI-2153有效抑制H-Ras蛋白的加工修饰，IC50值为10nM，是对其抑制活性是对Rap1A蛋白加工的3000多倍。
GC60860 FSL-1 TFA
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
GC60859 Fructosyl-lysine dihydrochloride
Ε-N-脱氧果糖赖氨酸二盐酸盐,Fructoselysine dihydrochloride
Fructosyl-lysine(Fructoselysine)dihydrochloride是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物(amadoriglycation)。Fructosyl-lysine是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。
GC60858 Freselestat quarterhydrate
ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate
Freselestatquarterhydrate(ONO-6818quarterhydrate)是一种有效且具有口服活性的嗜中性粒细胞弹性蛋白酶(neutrophilelastase)抑制剂，Ki为12.2nM。Freselestatquarterhydrate对其他蛋白酶（例如胰蛋白酶，蛋白酶3，胰弹性蛋白酶，纤溶酶，凝血酶，胶原酶，组织蛋白酶G和鼠巨噬细胞弹性蛋白酶）的活性低100倍以上，并具有有效的抗炎活性。
GC60856 FOY 251 An active metabolite of camostat