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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC49685 Trifluoroacetyl Tripeptide-2 (acetate)

    F3Ac-Val-Tyr-Val

     A peptide inhibitor of pancreatic and neutrophil elastases
  3. GC49678 Heptadecanoyl-L-carnitine-d3 (chloride) MaxSpec® Standard

    CAR 17:0-d3, C17:0 Carnitine-d3, L-Carnitine heptadecanoyl ester-d3, L-Heptadecanoylcarnitine-d3

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
  4. GC49677 Olmesartan-d6

    奥美沙坦 d6

     An internal standard for the quantification of olmesartan
  5. GC49676 6β-hydroxy Budesonide A metabolite of budesonide
  6. GC49655 5-hydroxy Buspirone

    5-羟基-8-[4-(嘧啶-2-基)-1-哌嗪基丁基]-8-氮杂螺[4,5]癸烷-7,9-二酮

     A metabolite of buspirone
  7. GC49637 O-desethyl Dapagliflozin

    达格列净杂质

     An SGLT2 inhibitor and active metabolite of dapagliflozin
  8. GC49629 6β-hydroxy Prednisolone

    泼尼松龙杂质D

     A metabolite of prednisolone
  9. GC49627 Rabeprazole sulfone

    雷贝拉唑杂质E

     A metabolite of rabeprazole
  10. GC49605 H-Gly-Pro-Hyp-OH (acetate)

    H-GP-Hyp-OH, Tripeptide-29

     A peptide DPP-4 inhibitor
  11. GC49597 Leukotriene B4-d5

    LTB4-d5

     An internal standard for the quantification of LTB4
  12. GC49590 Docosahexaenoic Acid 1,2,3,4-13C

    C22:6 n-3 1,2,3,4-13C, C22:6(4Z,7Z,10Z,13Z,16Z,19Z) 1,2,3,4-13C, Cervonic Acid 1,2,3,4-13C, DHA 1,2,3,4-13C

     An internal standard for the quantification of DHA
  13. GC49583 N-desmethyl Sertraline (hydrochloride)

    N-desmethyl Sertraline

     A metabolite of sertraline
  14. GC49575 4-hydroxy Omeprazole sulfide

    埃索美拉唑有关物质

     A metabolite of omeprazole
  15. GC49565 Roxatidine

    罗沙替丁

     A histamine H2 receptor antagonist and major active metabolite of roxatidine acetate
  16. GC49559 Hydroxymethyl Tolperisone (hydrochloride) A metabolite of tolperisone
  17. GC49544 8-hydroxy Mirtazapine

    8-羟基米安色林

     A metabolite of mirtazapine
  18. GC49538 Lamotrigine N2-oxide

    拉莫三嗪N2-氧化物

     A metabolite of lamotrigine
  19. GC49529 Thymidine-d4

    胸苷-ALPHA,ALPHA,ALPHA,6-D4,DThyd-d4; NSC 21548-d4

     An internal standard for the quantification of thymidine
  20. GC49511 Nicorandil N-oxide

    尼可地尔氮氧化物

     A metabolite of nicorandil
  21. GC49501 Nirvanol

    5-乙基-5-苯基海因

     An active metabolite of mephenytoin
  22. GC49488 6-Methylmercaptopurine-d3

    6-甲巯基嘌呤-D3

     An internal standard for the quantification of 6-MMP
  23. GC49480 Salicylic Acid-d4

    水杨酸-D4

     An internal standard for the quantification of salicylic acid
  24. GC49479 Hypoxanthine-d4

    次黄嘌呤

     An internal standard for the quantification of hypoxanthine
  25. GC49472 Methylmalonic Acid-d3

    甲基(D3)丙二酸,Methylpropanedioic acid-d3; Methylmalonate-d3

     An internal standard for the quantification of methylmalonic acid
  26. GC49457 Oleoyl-Coenzyme A (sodium salt)

    Oleoyl (cis-9-C18:1)-CoA, Oleoyl-CoA

     酰基辅酶A硫酯
  27. GC49454 Complex 3 A fluorescent copper complex with anticancer activity
  28. GC19897 Albendazole Sulfone

    阿苯达唑砜

     An active metabolite of albendazole
  29. GC63765 Hydroxytyrosol-d5

    DOPET-d5; 3,4-Dihydroxyphenethyl alcohol-d5; 3-Hydroxytyrosol-d5

    Hydroxytyrosol-d5 (DOPET-d5) 是 Hydroxytyrosol 的氘代物。Hydroxytyrosol (DOPET) 是从橄榄树及其叶子中提取的一种酚类化合物，具有抗氧化、抗动脉粥样硬化、抗血栓、抗菌、抗炎和抗肿瘤的作用。
  30. GC63732 Sacubitril-13C4 hemicalcium salt

    AHU-377-13C4 hemicalcium salt

     Sacubitril-13C4 (AHU-377-13C4) hemicalcium salt 是 13C 和氘代标记的 Sacubitril hemicalcium salt。Sacubitril (AHU-377) hemicalcium salt 是有效的NEP抑制剂，IC50值为5 nM。Sacubitril hemicalcium salt 是研究心力衰竭药物 LCZ696 的一个组分。
  31. GC63729 GPX4-IN-3 GPX4-IN-3 (26a) 是有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂，可选择性诱导铁死亡 (ferroptosis)。GPX4-IN-3 (26a) 在1 μM 的浓度可抑制GPX4 71.7% 活性。
  32. GC63693 UK122 UK122 是一种有效的，选择性尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，IC50 为 0.2 μM。UK122 对组织型 PA (tPA)、纤溶酶、凝血酶和胰蛋白酶没有或几乎没有抑制作用(IC50>100 μM)。UK122 是 4-恶唑烷酮类似物，一种抗癌剂，可抑制癌细胞迁移和侵袭。
  33. GC63688 DEHP-d4

    邻苯二甲酸二(2-乙基己酯),Bis(2-ethylhexyl) phthalate-d4; Ergoplast FDO-d4; ESBO-D 82-d4

     DEHP-d4 (Bis(2-ethylhexyl) phthalate-d4) 是 DEHP 的氘代物。DEHP (Bis(2-ethylhexyl) phthalate) 是一种内源性代谢产物。
  34. GC63684 Omeprazole sulfide-d3

    Ufiprazole-d3

     Omeprazole sulfide-d3 (Ufiprazole-d3) 是 Omeprazole sulfide 的氘代物。Omeprazole sulfide (Ufiprazole) 是 Omeprazole 的代谢物。
  35. GC63669 T0467 T0467 以 PINK1 依赖的方式激活线粒体 parkin 易位。T0467 不诱导多巴胺能神经元中 PINK1 的线粒体聚集。T0467 是一种潜在的PINK1-Parkin 信号激活化合物，可用于帕金森病及相关疾病的研究。
  36. GC63661 Aderbasib

    (6S,7S)-7-[(羟基氨基)甲酰基]-6-[(4-苯基-1-哌嗪基)甲酰基]-5-氮杂螺[2.5]辛烷-5-甲酸甲酯,INCB007839; INCB7839

     Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性，可用于癌症研究，包括弥漫性大 B 细胞非霍奇金淋巴瘤，HER2+ 乳腺癌，胶质瘤等。
  37. GC63642 Agaric acid

    落叶松蕈酸,Agaricinic Acid

     Agaric acid (Agaricinic Acid) 来自真菌部落的 Polyporus officinalis 和 Polyporus igniarius。Agaric acid 通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。Agaric acid 可促进积累的 Ca2+ 流出，跨膜电位的破坏和线粒体肿胀。Agaric acid 用于调节脂类代谢。
  38. GC63624 tert-Buthyl Pitavastatin

    匹伐他汀叔丁酯

     tert-Buthyl Pitavastatin 是 Pitavastatin 的代谢物。Pitavastatin 是一种有效的 HMG-CoA 还原酶抑制剂。
  39. GC63621 Doxycycline

    多西环素

     Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。
  40. GC63605 Taraxerone

    蒲公英赛酮

     Taraxerone 是从景天中分离出来的。Taraxerone 增强乙醇脱氢酶 (ADH) 和乙醛脱氢酶 (ALDH) 活性，EC50 值分别为 512.42 μM 和 500.16 μM。
  41. GC63603 19-Hydroxyandrost-4-ene-3,17-dione

    19-羟基雄甾-4-烯-3,17-二酮

     19-Hydroxyandrost-4-ene-3,17-dione是促肾上腺皮质激素-促脂解素和细胞色素P450 19A1的底物。
  42. GC63581 Isovaleric acid-d9

    异戊酸-D9

     Isovaleric acid-d9 是 Isovaleric acid 的氘代物。Isovaleric acid 是一种天然脂肪酸，可能和人类新生儿死亡以及牙买加呕吐病有关。
  43. GC63577 Benzamide-15N

    苯甲酰胺-15N,Benzenecarboxamide-15N; Phenylamide-15N

     Benzamide-15N (NSC-3114-15N) 是一种 15N 标记的 Benzamide. Benzamide 可抑制 poly(ADP-ribose) polymerase (PARP).
  44. GC63497 Pedalitin

    5,6,3',4'-四羟基-7-甲氧基黄酮

     Pedalitin 是酪氨酸酶（IC50=0.28 mM）和α-葡萄糖苷酶抑制剂（IC50=0.29 mM）。
  45. GC63481 Succinic acid-d6

    丁二酸-D6,Wormwood acid-d6

     Succinic acid-d6 (Wormwood acid-d6) 是 Succinic acid 的氘代物。Succinic acid 是三羧酸循环的中间产物，也是无氧代谢的发酵产物之一。
  46. GC63467 Hydroxypyruvic acid lithium hydrate

    β-Hydroxypyruvic acid lithium hydrate; 3-Hydroxypyruvic acid lithium hydrate

     Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) 是甘氨酸、丝氨酸和苏氨酸代谢的中间产物 (intermediate)。Hydroxypyruvic acid lithium hydrate 是丝氨酸-丙酮酸氨基转移酶和乙醛酸还原酶/羟基丙酮酸还原酶的底物 (substrate)。Hydroxypyruvic acid lithium hydrate 参与了二甲基甘氨酸脱氢酶缺乏症的代谢紊乱途径。
  47. GC63435 LTA4H-IN-1

    (ΒS)-Β-氨基-5-[4-[(5-氯-3-氟-2-吡啶基)氧基]苯基]-2H-四唑-2-丁酸

     An inhibitor of LTA4 hydrolase
  48. GC63423 Inclisiran

    ALN-PCSsc

     Inclisiran (ALN-PCSsc) 是一种双链小干扰 RNA (siRNA) 分子，可抑制 PCSK-9 的转录。Inclisiran 可用于高脂血症和心血管疾病 (CVD) 研究。
  49. GC63407 PF-06648671 PF-06648671 是一种新型的，可通透血脑屏障的，具有口服活性的 γ 分泌酶 (γ‐Secretase) 调节剂 (GSM)。PF-06648671 减少 Aβ42 和 Aβ40，并且伴随 Aβ37 和 Aβ38 的增加。PF-06648671 用于阿尔茨海默病的研究。
  50. GC63399 HIV-1 integrase inhibitor 8

    3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇

     HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，化合物 8。
  51. GC63389 DP-1 DP-1 是 SDC-TRAP-0063 的降解产物，是 Ganetespib 的一个片段。Ganetespib 是一种具有抗肿瘤活性的热休克蛋白 90 (HSP90) 抑制剂。

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