Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC62734 (E)-Oct-2-enoic acid

    2-辛烯酸

    2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
  3. GC62731 (2R,3R)-Butane-2,3-diol

    (2R,3R)-(-)-2,3-丁二醇

    (2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
  4. GC49437 Gliotoxin-13C13

    Aspergillin-13C13

    An internal standard for the quantification of gliotoxin
  5. GC49428 O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine A major metabolite of amlodipine
  6. GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone
  7. GC49410 CVT-2738

    N-(2,6-二甲基苯基)-1-哌嗪乙酰胺

    An active metabolite of ranolazine
  8. GC49409 Desmethyl Ranolazine

    雷诺嗪杂质

    A metabolite of ranolazine
  9. GC49406 ACT-373898 A metabolite of macitentan
  10. GC49403 Benzarone

    苯扎隆,Fragivix

    An active metabolite of benzbromarone
  11. GC49399 N-Desbutyl Dronedarone (hydrochloride)

    N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride

    An active metabolite of dronedarone
  12. GC49391 7α-Thiospironolactone

    Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL

    An active metabolite of spironolactone
  13. GC49386 Tepoxalin

    替泊沙林

    A dual inhibitor of COX and 5-LO
  14. GC49382 L-Lysine-d3 (hydrochloride)

    L-赖氨酸 d3 (盐酸)

    An internal standard for the quantification of L-lysine
  15. GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine
  16. GC49366 1-Salicylate Glucuronide

    Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide

    A metabolite of salicylic acid and aspirin
  17. GC49365 25-Desacetyl Rifampicin

    25-乙酰-3-[(五)-[(4-甲基-1-哌嗪基)亚胺]甲基]利福霉素

    A major active metabolite of rifampicin
  18. GC49364 3-Hydroxycoumarin

    3-羟基香豆素

    A coumarin with diverse biological activities
  19. GC49363 Salicyluric Acid

    2-羟基马尿酸

    A major metabolite of aspirin and salicylic acid
  20. GC49359 IM-156 (acetate)

    HL156A, HL271

    A mitochondrial complex I inhibitor and an AMPKα activator
  21. GC49356 17(S)-HDoTE

    17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid

    A metabolite of adrenic acid
  22. GC49355 Norfluoxetine-d5 (hydrochloride)

    诺氟西汀-D5

    An internal standard for the quantification of norfluoxetine
  23. GC49349 O-Desethyl Sildenafil

    西地那非杂质C

    A metabolite of sildenafil
  24. GC49340 Pitavastatin lactone-d4 An internal standard for the quantification of pitavastatin lactone
  25. GC49337 4-Acetamidobenzenesulfonamide

    对乙酰胺基苯磺酰胺

    A metabolite of asulam and sulfanilamide
  26. GC49330 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)

    2-(2-氨乙基)-3-(4-氯苯基)-3-羟基苯并[C]吡咯酮盐酸

    A metabolite of mazindol
  27. GC49318 Benzovindiflupyr A fungicide
  28. GC49316 O-Desmethyl-N-deschlorobenzoyl Indomethacin A metabolite of indomethacin
  29. GC49315 5-hydroxy Indomethacin

    O-去甲吲哚美辛

    A metabolite of indomethacin
  30. GC49298 7α-Thiomethylspironolactone

    SC 26519

    A major metabolite of spironolactone
  31. GC49294 1-(4-Chlorobenzhydryl)piperazine

    1-(4-氯二苯甲基)哌嗪

    An inactive metabolite of meclizine and chlorcyclizine
  32. GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine
  33. GC49289 Dolutegravir O-β-D-Glucuronide

    Dolutegravir Glucuronide, DTG Glucuronide

    A metabolite of dolutegravir
  34. GC49288 Dolutegravir M1

    多替拉韦杂质

    A metabolite of dolutegravir
  35. GC49282 Hydroxy Lenalidomide

    羟基来那度胺

    A metabolite of lenalidomide
  36. GC49256 N-acetyl Lenalidomide

    N-乙酰来那度胺

    A metabolite of lenalidomide
  37. GC49252 4’-hydroxy Trazodone A metabolite of trazodone
  38. GC49250 Hydroxydehydro Nifedipine Carboxylate

    羟基去氢硝苯羧酸酯

    A metabolite of nifedipine
  39. GC49241 Methyl Diethyldithiocarbamate

    S-甲基N,N二乙基二硫代氨基甲酸

    An active metabolite of disulfiram
  40. GC49235 6-Methylmercaptopurine

    6-甲巯基嘌呤

    A metabolite of 6-mercaptopurine
  41. GC49229 Ganodermanontriol

    灵芝马酮

    A triterpene with diverse biological activities
  42. GC49222 Mitoquinol-d15 An internal standard for the quantification of mitoquinol
  43. GC49221 QLT0267 An ILK inhibitor
  44. GC49219 N-desmethyl Eletriptan

    N-去甲基依曲普坦

    A metabolite of eletriptan
  45. GC49218 Imidafenacin Metabolite M4

    咪达那新相关物质2(N-(3氨基甲酰基3,3-DIPHENYLPROPYL)乙二酰二胺)

    A metabolite of imidafenacin
  46. GC49217 Trifluoperazine N-Glucuronide

    三氟拉嗪N-Β-D-葡糖苷酸,UGT1A4

    A metabolite of trifluoperazine
  47. GC49216 ADL 08-0011 (hydrochloride)

    阿维莫潘代谢物(ADL08-0011)盐酸盐

    An active metabolite of alvimopan
  48. GC49213 trans-hydroxy Glimepiride

    反式羟基格列美脲

    An active metabolite of glimepiride
  49. GC49212 trans-carboxy Glimepiride

    格列美脲杂质8

    A metabolite of glimepiride
  50. GC49211 O-desmethyl Brinzolamide (hydrochloride) An active metabolite of brinzolamide
  51. GC49210 N-desethyl Brinzolamide (oxalate)

    AL 8520

    An active metabolite of brinzolamide

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