Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
Products for Proteases
- Aminopeptidase(20)
- ACE(73)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(24)
- Gamma Secretase(42)
- HCV Protease(35)
- HSP(102)
- HIV Integrase(28)
- HIV Protease(34)
- MMP(191)
- NS3/4a protease(4)
- Serine Protease(15)
- Thrombin(44)
- Urokinase(2)
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(63)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(505)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1719)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(34)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(262)
- Mitochondrial Metabolism(248)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(13)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(115)
- PCSK9(13)
- ADAMTS(1)
- TrxR(1)
- DGK(3)
- Cat.No. 产品名称 Information
-
GC62734
(E)-Oct-2-enoic acid
2-辛烯酸
2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma. -
GC62731
(2R,3R)-Butane-2,3-diol
(2R,3R)-(-)-2,3-丁二醇
(2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite. -
GC49437
Gliotoxin-13C13
Aspergillin-13C13
An internal standard for the quantification of gliotoxin -
GC49428
O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
A major metabolite of amlodipine
-
GC49421
Atorvastatin lactone-d5
An internal standard for the quantification of atorvastatin lactone
-
GC49410
CVT-2738
N-(2,6-二甲基苯基)-1-哌嗪乙酰胺
An active metabolite of ranolazine -
GC49409
Desmethyl Ranolazine
雷诺嗪杂质
A metabolite of ranolazine -
GC49406
ACT-373898
A metabolite of macitentan
-
GC49403
Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone -
GC49399
N-Desbutyl Dronedarone (hydrochloride)
N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride
An active metabolite of dronedarone -
GC49391
7α-Thiospironolactone
Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL
An active metabolite of spironolactone -
GC49386
Tepoxalin
替泊沙林
A dual inhibitor of COX and 5-LO -
GC49382
L-Lysine-d3 (hydrochloride)
L-赖氨酸 d3 (盐酸)
An internal standard for the quantification of L-lysine -
GC49367
4’-hydroxy Atomoxetine Glucuronide (hydrate)
A metabolite of atomoxetine
-
GC49366
1-Salicylate Glucuronide
Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide
A metabolite of salicylic acid and aspirin -
GC49365
25-Desacetyl Rifampicin
25-乙酰-3-[(五)-[(4-甲基-1-哌嗪基)亚胺]甲基]利福霉素
A major active metabolite of rifampicin -
GC49364
3-Hydroxycoumarin
3-羟基香豆素
A coumarin with diverse biological activities -
GC49363
Salicyluric Acid
2-羟基马尿酸
A major metabolite of aspirin and salicylic acid -
GC49359
IM-156 (acetate)
HL156A, HL271
A mitochondrial complex I inhibitor and an AMPKα activator -
GC49356
17(S)-HDoTE
17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid
A metabolite of adrenic acid -
GC49355
Norfluoxetine-d5 (hydrochloride)
诺氟西汀-D5
An internal standard for the quantification of norfluoxetine -
GC49349
O-Desethyl Sildenafil
西地那非杂质C
A metabolite of sildenafil -
GC49340
Pitavastatin lactone-d4
An internal standard for the quantification of pitavastatin lactone
-
GC49337
4-Acetamidobenzenesulfonamide
对乙酰胺基苯磺酰胺
A metabolite of asulam and sulfanilamide -
GC49330
2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)
2-(2-氨乙基)-3-(4-氯苯基)-3-羟基苯并[C]吡咯酮盐酸
A metabolite of mazindol -
GC49318
Benzovindiflupyr
A fungicide
-
GC49316
O-Desmethyl-N-deschlorobenzoyl Indomethacin
A metabolite of indomethacin
-
GC49315
5-hydroxy Indomethacin
O-去甲吲哚美辛
A metabolite of indomethacin -
GC49298
7α-Thiomethylspironolactone
SC 26519
A major metabolite of spironolactone -
GC49294
1-(4-Chlorobenzhydryl)piperazine
1-(4-氯二苯甲基)哌嗪
An inactive metabolite of meclizine and chlorcyclizine -
GC49291
rac-N-desmethyl Ivabradine-d6 (hydrochloride)
An internal standard for the quantification of N-desmethyl ivabradine
-
GC49289
Dolutegravir O-β-D-Glucuronide
Dolutegravir Glucuronide, DTG Glucuronide
A metabolite of dolutegravir -
GC49288
Dolutegravir M1
多替拉韦杂质
A metabolite of dolutegravir -
GC49282
Hydroxy Lenalidomide
羟基来那度胺
A metabolite of lenalidomide -
GC49256
N-acetyl Lenalidomide
N-乙酰来那度胺
A metabolite of lenalidomide -
GC49252
4’-hydroxy Trazodone
A metabolite of trazodone
-
GC49250
Hydroxydehydro Nifedipine Carboxylate
羟基去氢硝苯羧酸酯
A metabolite of nifedipine -
GC49241
Methyl Diethyldithiocarbamate
S-甲基N,N二乙基二硫代氨基甲酸
An active metabolite of disulfiram -
GC49235
6-Methylmercaptopurine
6-甲巯基嘌呤
A metabolite of 6-mercaptopurine -
GC49229
Ganodermanontriol
灵芝马酮
A triterpene with diverse biological activities -
GC49222
Mitoquinol-d15
An internal standard for the quantification of mitoquinol
-
GC49221
QLT0267
An ILK inhibitor
-
GC49219
N-desmethyl Eletriptan
N-去甲基依曲普坦
A metabolite of eletriptan -
GC49218
Imidafenacin Metabolite M4
咪达那新相关物质2(N-(3氨基甲酰基3,3-DIPHENYLPROPYL)乙二酰二胺)
A metabolite of imidafenacin -
GC49217
Trifluoperazine N-Glucuronide
三氟拉嗪N-Β-D-葡糖苷酸,UGT1A4
A metabolite of trifluoperazine -
GC49216
ADL 08-0011 (hydrochloride)
阿维莫潘代谢物(ADL08-0011)盐酸盐
An active metabolite of alvimopan -
GC49213
trans-hydroxy Glimepiride
反式羟基格列美脲
An active metabolite of glimepiride -
GC49212
trans-carboxy Glimepiride
格列美脲杂质8
A metabolite of glimepiride -
GC49211
O-desmethyl Brinzolamide (hydrochloride)
An active metabolite of brinzolamide
-
GC49210
N-desethyl Brinzolamide (oxalate)
AL 8520
An active metabolite of brinzolamide