Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC38363 (R)-pyrrolidine-2-carboxylic acid
D-脯氨酸,(+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
D-proline is an isomer of the naturally occurring amino acid, L-Proline.
GC38362 KSD 2405
3-羟基苯甲醇
3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals.
GC38360 3-Methylbut-2-enoic acid
3,3-二甲基丙烯酸
Senecioic acid (3-Methylcrotonic acid, 3,3-Dimethylacrylic acid, β-Methylcrotonic Acid) is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria.
GC38359 1H-pyrazole
吡唑
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
GC38358 5'-Cytidylic acid
胞苷酸; 5'-Cytidylic acid; 5'-CMP
A pyrimidine nucleotide
GC38356 Imidazoleacetic acid hydrochloride
4-咪唑乙酸盐酸盐,Imidazolyl-4-acetic acid hydrochloride
Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.
GC38332 Ximelagatran
希美加群,H 376/95
A prodrug of melagatran, a thrombin inhibitor
GC38327 Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate
异柠檬酸三钠盐
Isocitric acid (DL-Isocitric acid) trisodium salt is an active endogenous metabolite.
GC38326 NSC 13138
喹啉-4-羧酸,Cinchoninic acid (6CI,7CI,8CI); 4-Carboxyquinoline
Quinoline-4-carboxylic acid (4-Carboxyquinoline) is a very important structure in a synthetic medicinal chemistry.
GC38325 N-Acetyl-D-mannosamine monohydrate
N-乙酰-D-甘露糖胺,Cyclic ManNAc
A precusor of sialic acid
GC38324 D-Galacturonic acid (hydrate)
D-半乳糖醛酸

A monosaccharide
GC38323 Tetrahydro-2H-pyran-2-one
delta-戊内酯
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite.
GC38321 2-Aminopyrimidin-5-ol
2-氨基-5-羟基嘧啶
2-Aminopyrimidin-5-ol 是一种内源性代谢产物。
GC38320 L-Methionine sulfoxide
L-蛋氨酸亚砜,H-Met(O)-OH
L-Methionine sulfoxide (H-Met(O)-OH)，甲硫氨酸的代谢产物，诱导 M1/classical 巨噬细胞极化，并调节氧化应激和嘌呤能的信号传递参数。
GC38317 Acetamide
乙酰胺
Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent.
GC38301 2-(1H-Indol-3-yl)ethan-1-ol
色醇; Tryptophol; Indole-3-ethanol
An indole with diverse biological activities
GC38300 Phytic acid potassium
植酸二钾
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
GC38299 (2-Aminoethyl)phosphonic acid
2-氨基乙基膦酸
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
GC38298 Pteridine-2,4(1H,3H)-dione
2,4-二羟基蝶啶
Pteridine-2,4(1H,3H)-dione 是一种内源性代谢产物。
GC38297 3-Methylindolin-2-one
3-甲基羟基吲哚
3-Methylindolin-2-one 是一种内源性代谢产物。
GC38296 (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
盐酸D-甘露糖胺
An amino monosaccharide
GC38295 N-Acetyl-DL-methionine
N-乙酰-DL-甲硫氨酸
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
GC38294 Heptadecanoic acid
十七烷酸
An odd-chain saturated fatty acid
GC38293 3-Amino-4-hydroxybenzoic acid
3-氨基-4-羟基苯甲酸
3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid.
GC38292 H-Trp-NH2.HCl
L-色氨酰胺盐酸盐
An endogenous metabolite of L-tryptophan
GC38291 Indole
吲哚
Indole (2,3-Benzopyrrole) is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria.
GC38290 NSC 45699
N-乙酰-L-苯丙氨酸; N-Acetylphenylalanine
A metabolite of L-phenylalanine
GC38289 N-Methylmethanamine hydrochloride
二甲胺盐酸盐
N-Methylmethanamine hydrochloride 是一种内源性代谢产物。
GC38288 Maleimide
马来酰亚胺
Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
GC38287 α-Pyridone
2-羟基吡啶,Pyridin-2-one; α-Hydroxypyridine
2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis.
GC38286 5,6-Dimethyl-1H-benzo[d]imidazole
5,6-二甲基苯并咪唑
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor.
GC38285 Flavonol
3-羟基黄酮
A synthetic flavonol
GC38284 Glycerophosphoric acid disodium salt hydrate
β-甘油磷酸钠水合物
Glycerophosphoric acid disodium salt hydrate 是一种内源性代谢物，是一种磷酸酶抑制剂。
GC38283 (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one
D-塔格糖; D-(-)-Tagatose
D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.
GC38282 (R)-5-Oxopyrrolidine-2-carboxylic acid
D-焦谷氨酸
A metabolite of D-glutamate
GC38281 2-Hydroxy-2-phenylacetic acid
扁桃酸,(±)-Mandelic acid; DL-Mandelic acid
2-羟基-2-苯乙酸（(±)-2-羟基-2-苯乙酸）是一种α-羟基羧酸，已广泛用作医药和精细化学品的中间体。
GC38277 trans-Cyclohexane-1,2-diol
1,2-环己二醇，顺反混合物
trans-Cyclohexane-1,2-diol 是一种内源性代谢产物。
GC38276 2-Oxosuccinic acid
草酰乙酸; 2-Oxosuccinic acid
2-Oxosuccinic acid（草酰乙酸）是一种α-酮酸，在柠檬酸循环的第一步中草酰乙酸与乙酰辅酶A和水反应形成柠檬酸盐，并在最后一步中通过L-苹果酸的氧化再生。
GC38275 Purine
嘌呤; Purine (6CI,8CI); 3,5,7-Triazaindole; 3H-Imidazo[4,5-d]pyrimidine; 6H-Imidazo[4,5-d]pyrimidine; 7H-Purine; Isopurine; NSC 753; β-Purine
An aromatic heterocyclic organic compound
GC38274 Oxalic acid dihydrate
草酸二水合物
Oxalic acid dihydrate 是一种内源性代谢产物。
GC38273 Methyl 2-(1H-indol-3-yl)acetate
吲哚-3-醋酸甲酯
Methyl 3-indolyacetate is a phytohormone.
GC38272 H-Phg(4-OH)-OH
L-(+)-对羟基苯甘氨酸,L-p-Hydroxyphenylglycine; 4-Hydroxy-L-phenylglycine; UK 25842
A CPT1 inhibitor and prodrug form of 4-hydroxyphenylglyoxylic acid
GC38271 1-Hydroxy-2-naphthoic acid
1-羟基-2-萘甲酸
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms.
GC38270 1-Aminocyclopropane-1-carboxylic acid
1-氨基环丙烷羧酸
An NMDA receptor partial agonist
GC38268 Indole-3-acetamide
3-吲哚乙酰胺
An endogenous metabolite of tryptophan in phytopathogenic bacteria
GC38266 Quinoline-2-carboxylic acid
喹哪啶酸
Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine.
GC38265 (2R,3R)-2,3-Dihydroxysuccinic acid
L-酒石酸; L-(+)-Tartaric acid
Tartaric acid (2,3-Dihydroxysuccinic acid, Threaric acid, Racemic acid, Uvic acid, Paratartaric acid, Winestone) is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use.
GC38264 Ac-Ala-OH
N-乙酰-L-丙氨酸
N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
GC38262 (R)-(-)-1,3-Butanediol
(R)-(-)-1,3-丁二醇
(R)-(-)-1,3-Butanediol 可以用于调节糖类脂类代谢。
GC38261 H-allo-Thr-OH
L-别苏氨酸,H-allo-Thr-OH
H-allo-Thr-OH 是一种内源性代谢产物。