Acetyl-CoA Carboxylase(乙酰辅酶A羧化酶)
Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.
Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).
Products for Acetyl-CoA Carboxylase
- Cat.No. 产品名称 Information
- GC70436 Propaquizafop Propaquizafop是一种苯氧异丙酸除草剂和乙酰辅酶a羧化酶抑制剂。
- GC68603 Acetyl-CoA Carboxylase-IN-1 Acetyl-CoA Carboxylase-IN-1 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,IC50 值为 <5 nM。 Acetyl-CoA Carboxylase-IN-1 具有抗菌活性。
- GC68587 A-908292 A-908292 是一种有效和选择性的乙酰辅酶 A 羧化酶 2 (ACC2) 抑制剂,抑制 hACC2 的 IC50 值为 23 nM。A-908292 可用于脂肪酸代谢的研究。
-
GC25726
PF-05221304
NSC 170984, R 6238, STAT5 Inhibitor III
PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL). -
GC64300
Haloxyfop
吡氟氯禾灵
Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide),广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 的抑制作的 IC50 为 0.5 μM,而对豌豆中该酶无影响。 -
GC61758
Fluazifop-P-butyl
精吡氟禾草灵
Fluazifop-P-butyl是一种来自芳基苯氧基丙酸酯的杀草剂,是一种乙酰辅酶A羧化酶(ACCase)抑制剂。 -
GC35740
CP-640186 hydrochloride
盐酸CP-640186
An ACC inhibitor -
GC32715
TOFA (RMI14514)
5-(十四烷基氧)-2-糠酸,RMI14514; MDL14514
TOFA (RMI14514)是乙酰辅酶A羧化酶-α (ACCA)的变构抑制剂。 -
GC32706
ND-646
ACC抑制剂(ND-646)
An ACC inhibitor - GC31344 MK-4074 MK-4074是乙酰辅酶A羧化酶(acetyl-CoAcarboxylase)的肝特异性抑制剂,IC50值约为3nM。
-
GC30047
Olumacostat glasaretil
DRM01
Olumacostatglasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。 - GC19284 PF-05175157 An inhibitor of ACC1 and 2
-
GC19261
ND-630 (Firsocostat)
ND-630; GS-0976; NDI-010976
An inhibitor of ACC1 and ACC2 - GC13434 CP-640186 An ACC inhibitor