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Acetyl-CoA Carboxylase(乙酰辅酶A羧化酶)

Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Products for  Acetyl-CoA Carboxylase

  1. Cat.No. 产品名称 Information
  2. GC70436 Propaquizafop Propaquizafop是一种苯氧异丙酸除草剂和乙酰辅酶a羧化酶抑制剂。
  3. GC68603 Acetyl-CoA Carboxylase-IN-1 Acetyl-CoA Carboxylase-IN-1 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,IC50 值为 <5 nM。 Acetyl-CoA Carboxylase-IN-1 具有抗菌活性。
  4. GC68587 A-908292 A-908292 是一种有效和选择性的乙酰辅酶 A 羧化酶 2 (ACC2) 抑制剂,抑制 hACC2 的 IC50 值为 23 nM。A-908292 可用于脂肪酸代谢的研究。
  5. GC25726 PF-05221304

    NSC 170984, R 6238, STAT5 Inhibitor III

    PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).
  6. GC64300 Haloxyfop

    吡氟氯禾灵

    Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide),广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 的抑制作的 IC50 为 0.5 μM,而对豌豆中该酶无影响。
  7. GC61758 Fluazifop-P-butyl

    精吡氟禾草灵

    Fluazifop-P-butyl是一种来自芳基苯氧基丙酸酯的杀草剂,是一种乙酰辅酶A羧化酶(ACCase)抑制剂。
  8. GC35740 CP-640186 hydrochloride

    盐酸CP-640186

    An ACC inhibitor
  9. GC32715 TOFA (RMI14514)

    5-(十四烷基氧)-2-糠酸,RMI14514; MDL14514

    TOFA (RMI14514)是乙酰辅酶A羧化酶-α (ACCA)的变构抑制剂。
  10. GC32706 ND-646

    ACC抑制剂(ND-646)

    An ACC inhibitor
  11. GC31344 MK-4074 MK-4074是乙酰辅酶A羧化酶(acetyl-CoAcarboxylase)的肝特异性抑制剂,IC50值约为3nM。
  12. GC30047 Olumacostat glasaretil

    DRM01

    Olumacostatglasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
  13. GC19284 PF-05175157 An inhibitor of ACC1 and 2
  14. GC19261 ND-630 (Firsocostat)

    ND-630; GS-0976; NDI-010976

    An inhibitor of ACC1 and ACC2
  15. GC13434 CP-640186 An ACC inhibitor

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