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Home >> Signaling Pathways >> Proteases >> Calpains

Calpains(钙蛋白酶)

Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).

Products for  Calpains

  1. Cat.No. 产品名称 Information
  2. GC13450 PD 145305 An inactive analog of PD 150606
  3. GC12479 Calpain Inhibitor XII

    Z-L-Nva-CONH-CH2-2-Py

     A selective inhibitor of calpain I
  4. GC16912 PD 150606 An inhibitor of calpains
  5. GC11640 MDL 28170

    Calpain Inhibitor III

     A cell permeable, selective calpain inhibitor
  6. GC10342 Calpeptin

    A calpain inhibitor
  7. GC12152 Acetyl-Calpastatin (184-210) (human)

    乙酰钙蛋白酶抑制蛋白(184-210)(人)

     Acetyl-Calpastatin (184-210) (human) 是一种有效、选择性和可逆的钙蛋白酶抑制剂，对 µ-calpain 和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。
  8. GC15066 Z-FA-FMK

    半胱氨酸蛋白酶抑制剂,Z-FA-FMK, Z-Phe-Ala-fluoromethyl ketone, Z-Phe-Ala-FMK, Zfa-FMK, Z-Phe-Ala-CH2F, Cathepsin B, Caspase Inhibitor

     An inhibitor of cysteine proteases, including cathepsin B
  9. GC10383 MG-132

    MG132,蛋白酶体抑制剂,MG132,Z-LLL-al,Z-Leu-Leu-Leu-CHO

     MG-132是一种强效、可逆和细胞渗透的蛋白酶体抑制剂，属于合成肽醛类。
  10. GC16383 Calpain Inhibitor II, ALLM

    钙蛋白酶抑制剂II(进口),N-Acetyl-Leu-Leu-Methional

     Calpain inhibitor
  11. GC12527 Calpain Inhibitor I, ALLN

    ALLN钙蛋白酶抑制剂,Ac-LLnL-CHO, MG-101, MG101,N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Nle-al,Calpain Inhibitor I

     A non-selective cysteine protease inhibitor
  12. GC13418 E-64

    N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺,Proteinase inhibitor E 64

     E-64是一种有效的不可逆的半胱氨酸蛋白酶抑制剂，对木瓜蛋白酶的IC50为9nM。

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