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Home >> Signaling Pathways >> Proteases >> Caspase

Caspase(半胱天冬酶蛋白)

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for  Caspase

  1. Cat.No. 产品名称 Information
  2. GC45193 Z-YVAD-CMK (trifluoroacetate salt)

    Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV

     An inhibitor of caspase-1 and caspase-3
  3. GC45189 Z-VAD(OH)-FMK

    Z-VAD(OH)-FMK

     Z-VAD(OH)-FMK是所有半胱天冬酶的不可逆三肽抑制剂。
  4. GC45178 Z-DEVD-CMK (trifluoroacetate salt)

    Z-Asp-Glu-Val-Asp-CMK

    An irreversible protease inhibitor
  5. GC45175 YVAD-CHO (trifluoroacetate salt)

    H-Tyr-Val-Ala-Asp-CHO

     A caspase-1/ICE inhibitor
  6. GC44409 Nivalenol

    雪腐镰刀菌烯醇

     A trichothecene mycotoxin
  7. GC43154 CAY10443

    (S)Indan1yl 3,4dichlorobenzylcarbamate

     A cytochrome c-dependent inducer of apoptosis
  8. GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)

    Ac-LEHD-CMK

     A caspase-9 inhibitor
  9. GC42718 Ac-VEID-CHO (trifluoroacetate salt)

    Ac-Val-Glu-Ile-Asp-CHO

     A caspase-6 inhibitor
  10. GC42715 Ac-VDVAD-CHO (trifluoroacetate salt)

    Ac-Val-Asp-Val-Ala-Asp-CHO

     A caspase-2, caspase-3, and caspase-7 inhibitor
  11. GC42709 Ac-LEVD-CHO (trifluoroacetate salt)

    Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I

     A caspase-4 inhibitor
  12. GC42688 Ac-DMQD-CHO (trifluoroacetate salt)

    Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor

     An inhibitor of caspase-3
  13. GC34831 Tauroursodeoxycholate dihydrate

    牛磺熊去氧胆酸二水合物; Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

     Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。
  14. GC40164 Ac-IETD-CHO (trifluoroacetate salt)

    Caspase-8 Inhibitor

     A caspase-8 inhibitor
  15. GC40149 Boc-AEVD-CHO (trifluoroacetate salt)

    Boc-Ala-Glu-Val-Asp-CHO

     An inhibitor of caspase-8
  16. GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)

    Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone

     A pan-caspase inhibitor
  17. GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)

    Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO

     A non-selective caspase inhibitor
  18. GC40122 Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)

    Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO, Ac-AAVALLPAVLLALLAP-DEVD-aldehyde, Ac-AAVALLPAVLLALLAPDEVD-CHO, Caspase-3 Inhibitor I, DEVD-CHO-CPP 32

     A caspase-3 inhibitor
  19. GC40118 Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)

    Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, Caspase-8 Inhibitor I

     An inhibitor of caspase-8 and granzyme B
  20. GC34181 Tauroursodeoxycholate (TUDCA)

    牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906

     牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。
  21. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)

    牛磺鹅去氧胆酸; 12-Deoxycholyltaurine

    A quantitative analytical standard guaranteed to meet MaxSpec  identity, purity, stability, and concentration specifications
  22. GC33309 ML132 (NCGC 00185682)

    NCGC-00183434

    ML132 (NCGC 00185682) (NCGC-00183434) 是一种选择性 caspase 1 抑制剂，IC50 为 34.9 nM。
  23. GC32998 Ginsenoside Rh4

    人参皂苷RH4

     Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
  24. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO是一种Caspase-3抑制剂，IC50值为0.016μM。
  25. GC31886 Chelidonic acid

    白屈菜酸

     A pyran with diverse biological activities
  26. GC31390 EP1013 (F1013)

    F1013

     EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂，用于 1 型糖尿病的研究。
  27. GC18476 Biotin-VAD-FMK A biotin-conjugated pan-caspase inhibitor
  28. GC12861 Z-VAD-FMK

    氟甲基酮,Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK

     Z-VAD-FMK（苄氧羰基-Val-Ala-Asp（OMe）氟甲基酮），是一种类似ICE的蛋白酶抑制剂，通过阻止CPP32转化为其活性形式来抑制细胞凋亡。
  29. GC12223 Z-Asp-CH2-DCB

    Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone

     A pan-caspase inhibitor
  30. GC11988 15-acetoxy Scirpenol

    15-乙酰蛇形菌素

     A trichothecene mycotoxin
  31. GC10661 Destruxin B

    黑僵菌素 B

     An insecticidal mycotoxin
  32. GC15880 Penicillic Acid

    青霉酸,NSC 402844

     A mycotoxin that inhibits quorum sensing
  33. GC12545 2-HBA

    Bis(2-hydroxybenzylidene)acetone

     An indirect inhibitor of Keap1-Nrf2 interactions
  34. GC17425 Sodium Tauroursodeoxycholate (TUDC)

    牛磺熊去氧胆酸钠; Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium

     Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达，例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。
  35. GC14188 Z-YVAD-FMK Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性 caspase-1 和 -4 抑制剂。
  36. GC17658 Guggulsterone

    香胶甾酮; Z/E-Guggulsterone

     Guggulsterone 是一种植物甾醇，来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin），调节细胞周期蛋白（cyclin D1 和c-Myc)，激活半胱天冬酶和 JNK，抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
  37. GC16990 Z-LEHD-FMK Z-LEHD-FMK 是一种选择性且不可逆的 caspase-9 抑制剂，可防止致命的再灌注损伤并减轻细胞凋亡。
  38. GC12407 Z-IETD-FMK

    CASPASE-8抑制剂,Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone, Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

     Z-IETD-FMK（Z-IE(OMe)TD(OMe)-FMK）是一种选择性和细胞可渗透的 caspase-8抑制剂。
  39. GC10978 Terfenadine

    特非那定; (±)-Terfenadine; MDL-991

     A selective histamine H1-receptor antagonist
  40. GC11908 Cisplatin

    顺铂; cis-Platinum; CDDP; cis-Diaminodichloroplatinum

     顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。
  41. GC12725 VX-765

    Belnacasan; N-(4-氨基-3-氯苯甲酰基)-3-甲基-L-缬氨酰-N-[(2R,3S)-2-乙氧基四氢-5-氧代-3-呋喃基]-L-脯氨酰胺; VX-765

    VX-765 是一种新开发的选择性小分子 caspase-1 抑制剂，可通过血脑屏障并在体外和体内减少炎症。
  42. GC10258 Ac-IEPD-AFC Ac-IEPD-AFC 是颗粒酶 B 的底物。
  43. GC14886 PETCM

    Α-(三氯甲基)-4-吡啶乙醇

     PETCM 是 caspase-3 的激活剂，并以细胞色素 c (细胞 c) 依赖性方式发挥作用。 PETCM 促进 Apaf-1 寡聚化并诱导 HeLa 细胞中的细胞凋亡。
  44. GC18137 Ivachtin

    Caspase-3 Inhibitor VII

     A reversible caspase-3 inhibitor
  45. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  46. GC10968 Ac-LEHD-AFC A caspase-4, -5, and -9 fluorogenic substrate
  47. GC12139 Gambogic Acid

    藤黄酸; Beta-Guttiferrin

     Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。
  48. GC14209 Apoptosis Activator 2

    1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮

     An activator of caspases
  49. GN10801 Senkyunolide I

    洋川芎内酯I

     Senkyunolide I 是从川芎中分离出来的，是一种抗偏头痛化合物。
  50. GN10629 5,7-dihydroxychromone

    5,7-二羟基色酮

     A flavone decomposition product with diverse biological activities
  51. GN10269 Wedelolactone

    蟛蜞菊内酯

     A natural NF-κB inhibitor

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