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Home >> Signaling Pathways >> Proteases >> Dipeptidyl Peptidase

Dipeptidyl Peptidase(二肽基肽酶)

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Products for  Dipeptidyl Peptidase

  1. Cat.No. 产品名称 Information
  2. GC70545 Fotagliptin benzoate Fotagliptin benzoate是二肽基肽酶IV（DPP-4）抑制剂（IC50=2.27nM）。
  3. GC69901 Sitagliptin fenilalanil hydrochloride Sitagliptin fenilalanil hydrochloride 是一种二肽氨基肽酶 (DPP-4) 抑制剂。
  4. GC69900 Sitagliptin fenilalanil Sitagliptin fenilalanil 是一种二肽氨基肽酶 (DPP-4) 抑制剂。
  5. GC68890 Cofrogliptin

    HSK7653

     Cofrogliptin (HSK7653) (compound 2)，一种四氢吡喃衍生物，是一种有效的口服 DPP-4 抑制剂，具有长效降糖作用。Cofrogliptin (compound 2) 在2型糖尿病 (T2DM) 应用中具有很大的潜力。
  6. GC66355 Linagliptin-d4

    BI 1356-d4

     Linagliptin-d4 是 Linagliptin 氘代物。Linagliptin 是一种有效，选择性的 DPP-4 抑制剂，IC50 值为 1 nM。
  7. GC63383 Sitagliptin-d4 phosphate

    磷酸西他列汀 d4 (磷酸盐)

     Sitagliptin-d4 (MK-0431-d4) phosphate 是 Sitagliptin phosphate 的氘代物。Sitagliptin phosphate (MK-0431 phosphate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞中，IC50 值为 19 nM。
  8. GC63170 Retagliptin

    SP2086

     Retagliptin (SP2086) 是一种选择性的竞争性，且具有口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin 可用于 2 型糖尿病 (T2DM) 的研究。
  9. GC62280 Teneligliptin D8

    特力利汀-D8,MP-513 D8

     Teneligliptin D8 (MP-513 D8) 一种氘标记的 Teneligliptin (MP-513)。Teneligliptin D8 (MP-513 D8) 是一种强效的、口服的、有竞争力的、持久的 DPP-4 抑制剂。
  10. GC47751 Nateglinide-d5

    那格列奈-D5,A4166 D5; Senaglinide D5

     An internal standard for the quantification of nateglinide
  11. GC60828 Evogliptin tartrate

    DA-1229 tartrate

     Evogliptintartrate是一种高效、口服有效、选择性的DPP-4抑制剂，具有抗糖尿病活性。Evogliptintartrate可用于靶向动脉炎症和动脉粥样硬化的研究。
  12. GC60613 Azaleatin

    杜鹃黄素

    Azaleatin是一种从Rhododendron种中分离得到的O-甲基化黄酮醇。Azaleatin是二肽基肽酶-IV的抑制剂。Azaleatin可用于2型糖尿病和肥胖症的研究。
  13. GC39296 1G244 1G244 是一种有效的 DPP8/9 抑制剂，IC50 分别为 12 nM 和 84 nM，但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡，并具有抗骨髓瘤作用。
  14. GC45436 Diprotin A

    抑二肽素A,Ile-Pro-Ile

     A tripeptide inhibitor of DPP-4
  15. GC37757 Teneligliptin hydrobromide hydrate

    氢溴酸替格列汀水合物,MP-513 hydrobromide hydrate

     A DPP-4 inhibitor
  16. GC37594 Saxagliptin hydrate

    沙格列汀单水化合物,BMS-477118 hydrate

    Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
  17. GC44874 Saxagliptin (hydrochloride)

    沙克列汀中间体,BMS-477118 hydrochloride

     A potent DPP-4 inhibitor
  18. GC44353 NDMC101 A salicylanilide derivative
  19. GC33853 Talabostat (PT100)

    [(2R)-1-[(2S)-2-氨基-3-甲基丁酰基]吡咯烷-2-基]硼酸,Val-boroPro; PT100

     Talabostat (PT100)是一种口服活性的二肽基肽酶IV DPP-IV IC50 < 4 nM的非选择性抑制剂;Ki = 0.18 nM，临床首个成纤维细胞活化蛋白FAP抑制剂IC50= 560 nM，抑制DPP 8/9的IC50= 4/11 nM;Ki = 1.5/0.76 nM，脯氨酸内肽酶QPP IC50= 310 nM, DPP2等DASH家族酶。
  20. GC33769 Gemigliptin (LC15-0444)

    吉格列汀酒石酸盐,LC15-0444

     Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
  21. GC32546 Prodipine hydrochloride

    普罗地平盐酸盐；卜罗哌苯盐酸盐

     Prodipine是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶IV(DPPIV)，IC50分别为4.5μM和30μM。
  22. GC31547 DPP-IV-IN-1 DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂，IC50值为4.6nM；DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。
  23. GC31492 Vildagliptin dihydrate (LAF237 dihydrate)

    维格列汀二水合物; LAF237 dihydrate; NVP-LAF 237 dihydrate

     A DPP-4 inhibitor
  24. GC31472 Retagliptin Phosphate (SP 2086)

    瑞格列汀磷酸盐,SP2086 phosphate

     Retagliptin Phosphate (SP 2086) (SP2086 phosphate) 是一种选择性、竞争性和口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。
  25. GC31467 Dutogliptin

    杜拓格利普汀,PHX-1149 free base

     Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。
  26. GC31463 Gosogliptin (PF-00734200)

    (3,3-二氟吡咯烷-1-基)[(2S,4S)-4-[4-(嘧啶-2-基)哌嗪-1-基]吡咯烷-2-基]甲酮,PF-00734200; PF-734200

    An inhibitor of DPP-4
  27. GC31444 Saikogenin A

    柴胡皂苷元A

     SaikogeninA可从中药柴胡中提取，是一种二肽基肽酶IV(DPP-IV)抑制剂。
  28. GC31414 Diprotin A TFA (Ile-Pro-Pro (TFA))

    Ile-Pro-Ile TFA

     A tripeptide inhibitor of DPP-4
  29. GC31341 Anagliptin (SK-0403)

    利格列汀; SK-0403

     A DPP-4 inhibitor
  30. GC31333 Teneligliptin (MP-513)

    特利列汀; MP-513

     Teneliligliptin (MP-513) (MP-513) 是一种有效的、可口服的、有竞争力的、长效的 DPP-4 抑制剂。
  31. GC31317 Sitagliptin (MK0431)

    西格列汀; MK-0431

     Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.
  32. GC30877 DPP-IV-IN-2 DPP-IV-IN-2是二肽基肽酶IV(DPIV)和DP8/9的抑制剂，其IC50值分别为0.1和0.95μM。
  33. GC19120 DBPR108 DBPR108 是一种有效的、选择性的、口服生物可利用的二肽衍生的 DPP4 抑制剂，IC50 为 15 nM。对 DDP8 和 DPP9 无抑制作用。
  34. GC19052 AZD7986

    Brensocatib; INS 1007

     An inhibitor of DPP-1
  35. GC12235 Sitagliptin (phosphate)

    磷酸西他列汀; MK-0431 phosphate

     A DPP-4 inhibitor
  36. GC17012 MK3102

    奥格列汀（MK-3102）,MK-3102

     MK3102 (Omarigliptin)是一种新型的每周一次的二肽基肽酶-4 (DPP-4)抑制剂(IC50: 2.2 nM)，用于治疗2型糖尿病。
  37. GC12360 UAMC 00039 dihydrochloride A potent DPP-2 inhibitor
  38. GC10018 Talabostat mesylate

    [(2R)-1-[(2S)-2-氨基-3-甲基丁酰基]吡咯烷-2-基]硼酸甲磺酸盐,Val-boroPro mesylate; PT100 mesylate

     Talabostat (PT100)是一种口服活性和非选择性二肽基肽酶IV（DPP-IV）抑制剂(IC50 < 4 nM; Ki = 0.18 nM)和成纤维细胞活化蛋白(FAP)的第一种临床抑制剂(IC50 = 560 nM)，抑制DPP 8/9(IC50= 4/11 nM; Ki = 1.5/0.76 nM)，静止细胞脯氨酸二肽酶(QPP)( IC50= 310 nM)，DPP 2和其他一些DASH家族酶。
  39. GC10091 Nateglinide

    那格列奈; A4166; Senaglinide

     A hypoglycemic agent
  40. GC12895 Saxagliptin

    沙格列汀; BMS-477118

     A potent DPP-4 inhibitor
  41. GC17479 Trelagliptin succinate

    曲格列汀琥珀酸盐; SYR-472 succinate

     A DDP-4 inhibitor
  42. GC16613 Trelagliptin

    曲格列汀; SYR-472

     A DDP-4 inhibitor
  43. GC15576 Teneligliptin hydrobromide

    氢溴酸替格列汀,MP-513 hydrobromide

     A DPP-4 inhibitor
  44. GC10171 Puromycin aminonucleoside

    氨基核苷嘌呤霉素; NSC 3056

    A glomerular epithelial cell toxin
  45. GC13949 Alogliptin Benzoate

    苯甲酸阿格列汀; SYR 322

     A DPP-4 inhibitor
  46. GC15130 Alogliptin (SYR-322)

    阿格列汀; SYR-322 free base

     Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂，IC50 <10 nM，选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
  47. GC16733 Vildagliptin (LAF-237)

    维格列汀; LAF237; NVP-LAF 237

     A DPP-4 inhibitor
  48. GC10298 Sitagliptin phosphate monohydrate

    西他列汀磷酸盐一水合物; MK-0431 phosphate monohydrate

     Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。
  49. GC14827 Linagliptin (BI-1356)

    利格列汀; BI 1356

     A potent DPP-4 inhibitor

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