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Home >> Signaling Pathways >> Proteases >> Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for  Drug Metabolite

  1. Cat.No. 产品名称 Information
  2. GC91641 4-Hydroxy-1-(2-phenylethyl)piperidine 4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).
  3. GC91492 Propiverine N-oxide Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine .
  4. GC71908 Deoxynivalenol-3-β-D-glucoside Deoxynivalenol-3-β-D-glucoside（DON-3-β-D-葡萄糖苷）是镰刀菌毒素脱氧雪腐镰刀菌烯醇的植物代谢产物。
  5. GC71042 18β-Glycyrrhetyl-3-O-sulfate 18β-Glycyrrhetyl-3-O-sulfate（甘草次酸3-O-（硫酸氢））是一种强效的2型11β-羟基类固醇脱氢酶（11β-HSD2）抑制剂，使用大鼠肾微粒体时IC50为0.10µM。
  6. GC70795 Voriconazole N-oxide hydrochloride Voriconazole N-oxide hydrochloride是伏立康唑的主要代谢产物，伏立康唑是一种广泛使用的三唑类抗生素（真菌）。
  7. GC70767 T-705RMP ammonium T-705RMP ammonium是T-705RMP的铵形式。
  8. GC70763 2-NP-AMOZ 2-NP-AMOZ是AMOZ(抗生素呋喃他酮的代谢物)的2-硝基苯衍生物，可用于检测蛋白结合的AMOZ。
  9. GC70731 Anhydrosimvastatin Anhydrosimvastatin（杂质C）是辛伐他汀的杂质。
  10. GC70728 ent-Ezetimibe ent-Ezetimibe（ent SCH 58235）是依折麦布的RRS对映异构体。
  11. GC70646 N-Methyl Palbociclib N-Methyl Palbociclib是Palbociclib的杂质。
  12. GC70645 Gefitinib impurity 1 Gefitinib impurity 1是吉非替尼的杂质。
  13. GC70597 5-Hydroxy Omeprazole-d3 5-Hydroxy Omeprazole-d3是氘标记的5-羟基奥美拉唑。
  14. GC70400 Mebendazole-amine Mebendazole-amine是甲苯达唑的代谢物。
  15. GC70222 cPrPMEDAP cPrPMEDAP是GS-9219的中间代谢物。
  16. GC70209 Didesethyl chloroquine-d4 Didesethyl chloroquine-d4是氘标记的二乙基氯喹。
  17. GC91480 Exendin-4 (3-39) amide (trifluoroacetate salt)

    Exendin (3-39)

     Exendin-4 (3-39)酰胺是一种糖肽样肽1受体（GLP-1R）激动剂，也是exendin-4 (48-86)酰胺的活性代谢物。
  18. GC91418 (E)-KPT-330

    KTP-330; trans Selinexor

     (E)-KPT-330是selinexor的代谢产物，它是exportin 1 (XPO1/CRM1)抑制剂的一种。它由细胞色素P450（CYP）亚型CYP3A4从selinexor中形成。
  19. GC91397 N-desmethyl Levofloxacin (hydrochloride)

    Desmethyl Levofloxacin

     N-去甲基左氧氟沙星是氟喹诺酮类抗生素左氧氟沙星的活性代谢产物。它对金黄色葡萄球菌、表皮葡萄球菌、枯草杆菌、大肠杆菌、铜绿假单胞菌和肺炎克雷伯杆菌具有活性（最小抑制浓度分别为4，1，1，0.012，> 4和0.25μg/ml）。
  20. GC91375 Promethazine Sulfoxide 盐酸普罗米嗪是组胺H1受体拮抗剂普罗米嗪的代谢产物。它由细胞色素P450（CYP）同工酶CYP2D6将普罗米嗪转化而成。
  21. GC26213 13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile

    二氢血根碱, DIHYDROSANGUINARINE

  22. GC91296 p-Carboxyphenyl Sulfate

    Benzoic Acid-4-sulfate, 4-Carboxyphenyl Sulfate, para-Carboxyphenyl Sulfate, 4-Hydroxybenzoic Acid Sulfate, p-Hydroxybenzoic Acid Sulfate, para-Hydroxybenzoic Acid Sulfate

    一种硫酸化的酚酸。
  23. GC91278 Doxepin N-oxide (hydrate)

    多西平的代谢产物。
  24. GC91083 Tiopronin-Cysteine Disulfide

    α-Mercaptopropionylglycine-Cysteine Disulfide

    一种硫普罗宁的代谢产物。
  25. GC91042 Tauro-Obeticholic Acid (sodium salt)

    Obeticholic Acid Taurine Conjugate, Tauro-OCA, Tauro-6-Ethyl-CDCA, Tauro-6-Ethylchenodeoxycholic Acid, T-ECDCA

    一种欧贝替胆酸的活性代谢物。
  26. GC90889 5-(3'-Hydroxyphenyl)-γ-Valerolactone

    δ-(3'-Hydroxyphenyl)-γ-Valerolactone, 5-(3'-Hydroxyphenyl)-γ-VL, δ-(3'-Hydroxyphenyl)-γ-VL, (3'-hydroxy)-PVL

    多种多酚的代谢产物。
  27. GC90883 Purine riboside-5'-O-triphosphate (sodium salt)

    PRTP, Purine Riboside Triphosphate, PTP, PuTP

    一种星形菜碱的活性代谢物。
  28. GC90841 8-Chloroadenosine-5'-triphosphate (sodium salt)

    8-chloro ATP

    8-氯cAMP的活性代谢物。
  29. GC90790 4-hydroxy Xylazine O-Glucuronide (lithium salt)

    p-hydroxy Xylazine O-Glucuronide, para-hydroxy Xylazine O-Glucuronide

    一种二甲基苯乙胺的代谢产物。
  30. GC90789 3-hydroxy Xylazine

    一种二甲基苯乙胺的代谢产物。
  31. GC90781 Ambroxol-d5 (hydrochloride)

    一种用于量化氨溴索的内部标准。
  32. GC90702 Triciribine Phosphate

    TCN-P, Triciribine-5'-monophosphate, NSC 280594

    一种Akt激活抑制剂，也是三环核苷的活性代谢物。
  33. GC90194 Ethyl-β-D-Glucuronide-d5

    Ethyl-β-D-Glucopyranosiduronic Acid-d5, Ethyl-β-D-Glucosiduronic Acid-d5

    一种用于乙基-β-D-葡萄糖醛酸盐定量的内部标准
  34. GC69835 RPR132595A hydrochloride

    NPC hydrochloride

     RPR132595A (NPC) hydrochloride 是 CPT-11 的活性代谢产物，它是由细胞色素 P-450 3A4 (CYP3A4) 产生并最终通过尿排出。
  35. GC69607 O-Demethyl Lenvatinib hydrochloride O-Demethyl Lenvatinib hydrochloride 是 Lenvatinib 的代谢物。Lenvatinib (E7080) 一种具有口服活性的，多靶点酪氨酸激酶抑制剂，VEGFR1-3、FGFR1-4、PDGFR、KIT 和 RET。Lenvatinib 显示有效抗癌的活性。
  36. GC69098 Febuxostat impurity 7

    非布索坦杂质7

     Febuxostat impurity 7 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
  37. GC68509 (25R)-12α-Hydroxyspirost-4-en-3-one (25R)-12α-Hydroxyspirost-4-en-3-one 是由 Nocardia globerula 作用于 Hecogenin 产生的一种次要代谢物。
  38. GC68387 FGN849

    FGN849 是 IMGN632 的活性有效载荷分解物。
  39. GC68324 3-Methoxytyramine-d4 hydrochloride

    3-O-methyl Dopamine-d4 hydrochloride

     3-Methoxytyramine-d4 (3-O-methyl Dopamine-d4) hydrochloride 是 3-Methoxytyramine hydrochloride 的氘代物。3-Methoxytyramine hydrochloride 是多巴胺的无活性代谢物，可以活化痕量胺相关受体1 (TAAR1)。
  40. GC68082 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetic acid 是 Mescaline 的代谢物。
  41. GC67988 6-Hydroxybenzbromarone

    6-羟基苯并溴马隆

    6-Hydroxybenzbromarone 是 Benzbromarone 的主要代谢产物 (metabolite)，比母体化合物具有更长的半衰期和更大的药理效力。6-Hydroxybenzbromarone 是一种 EYA3 抑制剂，IC50 值为 21.5 μM。6-Hydroxybenzbromarone 是一种血管生成剂，对细胞迁移，肾小管生成和血管生成具有强大的抑制作用。
  42. GC67902 3-Amino-2-oxazolidinone-d4

    AOZ-d4

     3-Amino-2-oxazolidinone-d4 是 3-Amino-2-oxazolidinone 的氘代物。3-Amino-2-oxazolidinone (AOZ) 是呋喃唑烷酮 的代谢物 (metabolite)。3-Amino-2-oxazolidinone 作为检测呋喃唑烷酮残留的一个指标。
  43. GC67766 Abiraterone sulfate Abiraterone sulfate 是 Abiraterone 的代谢物。Abiraterone 是一种不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。
  44. GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3 是 (Z)-10-Hydroxynortriptyline 的氘代物。(Z)-10-Hydroxynortriptyline 是 Nortriptyline 的代谢物。Nortriptyline 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢物，用于缓解抑郁症状。
  45. GC52478 Telmisartan Acyl-β-D-Glucuronide (hydrate)

    Telmisartan Glucuronide

     A major metabolite of telmisartan
  46. GC52368 DL-Sulforaphane Glutathione

    SFN-glutathione, SFN-GSH, Sulforaphane-GSH

     A metabolite of sulforaphane
  47. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate

    3-HPPA sulfate

     A metabolite of certain phenols and glycosides
  48. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone

    (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL

     An active metabolite of various polyphenols
  49. GC66449 Ferulic acid 4-O-sulfate

    Ferulic acid 4-sulfate

     Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) 是 Ferulic acid 的代谢物。Ferulic acid 4-O-sulfate 可以放松小鼠的动脉，降低血压。$
  50. GC66063 Tulipalin A

    郁金香素A; α-Methylene butyrolactone

     2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA).
  51. GC66057 10,11-Dihydrocarbamazepine

    10,11-二氢卡马西平

     10,11-二氢卡马西平（10,11-Dihydrocarbamazepine）用作液相色谱法同时测定血浆中卡马西平及其活性代谢物的内标。可用于化学发光法测定卡马西平的含量。

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