Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for Drug Metabolite

Cat.No. 产品名称 Information
GC64336 2-Hydroxyemodin
2-羟基大黄素
2-Hydroxyemodin 是肝微粒体中大黄素的活性代谢物。大黄素是一种存在于真菌代谢物和大黄成分中的蒽醌。在没有激活系统的情况下，2-Hydroxyemodin 对鼠伤寒沙门氏菌 TA1537 具有诱变作用。
GC64335 N-Desmethyl imatinib-d8
N-去甲基伊马替-D8,Norimatinib-d8; Imatinib metabolite N-Desmethyl imatinib-d8
N-Desmethyl imatinib D8 (Norimatinib D8) 是 N-Desmethyl imatinib 的氘代化合物。
GC64076 Nortriptyline
去甲替林,Desmethylamitriptyline; Desitriptilina
Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
GC63958 6α-Hydroxy Paclitaxel-d5
紫杉醇杂质
6α-Hydroxy Paclitaxel-d5 是 6α-Hydroxy paclitaxel 的氘代物。6α-Hydroxy paclitaxel 是紫杉醇的初级代谢物。6α-Hydroxy paclitaxel 对有机阴离子转运多肽 1B1/SLCO1B1 (OATP1B1) 具有与紫杉醇相似的时间依赖性抑制效力，但它对 OATP1B3 不具有时间依赖性作用。6α-Hydroxy paclitaxel 可用于癌症研究。
GC49698 Indomethacin Acyl Glucuronide
(吲哚美辛酰基)-Β-D-葡糖苷酸
A metabolite of indomethacin
GC49686 N-desmethyl Regorafenib N-oxide
瑞戈非尼杂质14
An active metabolite of regorafenib
GC49677 Olmesartan-d6
奥美沙坦 d6
An internal standard for the quantification of olmesartan
GC49676 6β-hydroxy Budesonide A metabolite of budesonide
GC49655 5-hydroxy Buspirone
5-羟基-8-[4-(嘧啶-2-基)-1-哌嗪基丁基]-8-氮杂螺[4,5]癸烷-7,9-二酮
A metabolite of buspirone
GC49637 O-desethyl Dapagliflozin
达格列净杂质
An SGLT2 inhibitor and active metabolite of dapagliflozin
GC49629 6β-hydroxy Prednisolone
泼尼松龙杂质D
A metabolite of prednisolone
GC49627 Rabeprazole sulfone
雷贝拉唑杂质E
A metabolite of rabeprazole
GC49583 N-desmethyl Sertraline (hydrochloride)
N-desmethyl Sertraline
A metabolite of sertraline
GC49575 4-hydroxy Omeprazole sulfide
埃索美拉唑有关物质
A metabolite of omeprazole
GC49565 Roxatidine
罗沙替丁
A histamine H₂ receptor antagonist and major active metabolite of roxatidine acetate
GC49559 Hydroxymethyl Tolperisone (hydrochloride) A metabolite of tolperisone
GC49544 8-hydroxy Mirtazapine
8-羟基米安色林
A metabolite of mirtazapine
GC49538 Lamotrigine N2-oxide
拉莫三嗪N2-氧化物
A metabolite of lamotrigine
GC49511 Nicorandil N-oxide
尼可地尔氮氧化物
A metabolite of nicorandil
GC49501 Nirvanol
5-乙基-5-苯基海因
An active metabolite of mephenytoin
GC49488 6-Methylmercaptopurine-d3
6-甲巯基嘌呤-D3
An internal standard for the quantification of 6-MMP
GC49480 Salicylic Acid-d4
水杨酸-D4
An internal standard for the quantification of salicylic acid
GC19897 Albendazole Sulfone
阿苯达唑砜
An active metabolite of albendazole
GC63684 Omeprazole sulfide-d3
Ufiprazole-d3
Omeprazole sulfide-d3 (Ufiprazole-d3) 是 Omeprazole sulfide 的氘代物。Omeprazole sulfide (Ufiprazole) 是 Omeprazole 的代谢物。
GC63624 tert-Buthyl Pitavastatin
匹伐他汀叔丁酯
tert-Buthyl Pitavastatin 是 Pitavastatin 的代谢物。Pitavastatin 是一种有效的 HMG-CoA 还原酶抑制剂。
GC63389 DP-1 DP-1 是 SDC-TRAP-0063 的降解产物，是 Ganetespib 的一个片段。Ganetespib 是一种具有抗肿瘤活性的热休克蛋白 90 (HSP90) 抑制剂。
GC63337 N-Acetyl Norgestimate-d6
GC63311 Omeprazole metabolite Omeprazole sulfone (methoxy-d3)
Omeprazole sulfone (methoxy-d3); Omeprazole sulphone (methoxy-d3)
Omeprazole metabolite Omeprazole sulfone (methoxy-d3) (Omeprazole sulfone (methoxy-d3)) 是 Omeprazole metabolite Omeprazole sulfone 的氘代物。Omeprazole sulfone是Omeprazole的代谢物。
GC63028 IYPTNGYTR acetate IYPTNGYTR acetate，一种脱酰胺敏感的特征肽，是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR acetate 可用于监测体内曲妥珠单抗的代谢。
GC62923 Dasatinib metabolite M6
达沙替尼羧酸; Dasatinib carboxylic acid
Dasatinib metabolite M6 (Dasatinib carboxylic acid) 是 Dasatinib 的氧化代谢物。Dasatinib 是一种具有口服活性的，ATP 竞争性的，双重 Src/Bcr-Abl 抑制剂，具有有效的抗肿瘤活性。
GC62845 Apoatropine hydrochloride
盐酸阿朴阿托品
Apoatropine hydrochloride 是从 Atropa belladonna 中分离出来的一种莨菪烷生物碱。
GC62824 Acetaminophen glucuronide
(4-乙酰氨基苯基)-葡糖苷酸,APAP-glu
An inactive metabolite of acetaminophen
GC62777 2-Methoxy-4-vinylphenol
4-乙烯基-2-甲氧基苯酚
2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。
GC62737 (R)-(-)-O-Desmethyl Venlafaxine D6
(R)-O-去甲文拉法辛 d6
(R)-(-)-O-Desmethyl Venlafaxine D6 是 (R)-(-)-O-Desmethyl Venlafaxine 的氘代物。O-Desmethyl Venlafaxine 是 Venlafaxine 的活性代谢产物。Venlafaxine 是 5-羟色胺-去甲肾上腺素再摄取抑制剂 (SNRI) 类的抗抑郁剂。
GC49428 O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine A major metabolite of amlodipine
GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone
GC49410 CVT-2738
N-(2,6-二甲基苯基)-1-哌嗪乙酰胺
An active metabolite of ranolazine
GC49409 Desmethyl Ranolazine
雷诺嗪杂质
A metabolite of ranolazine
GC49406 ACT-373898 A metabolite of macitentan
GC49403 Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone
GC49399 N-Desbutyl Dronedarone (hydrochloride)
N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride
An active metabolite of dronedarone
GC49391 7α-Thiospironolactone
Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL
An active metabolite of spironolactone
GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine
GC49366 1-Salicylate Glucuronide
Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide
A metabolite of salicylic acid and aspirin
GC49365 25-Desacetyl Rifampicin
25-乙酰-3-[(五)-[(4-甲基-1-哌嗪基)亚胺]甲基]利福霉素
A major active metabolite of rifampicin
GC49363 Salicyluric Acid
2-羟基马尿酸
A major metabolite of aspirin and salicylic acid
GC49355 Norfluoxetine-d5 (hydrochloride)
诺氟西汀-D5
An internal standard for the quantification of norfluoxetine
GC49349 O-Desethyl Sildenafil
西地那非杂质C
A metabolite of sildenafil
GC49340 Pitavastatin lactone-d4 An internal standard for the quantification of pitavastatin lactone
GC49337 4-Acetamidobenzenesulfonamide
对乙酰胺基苯磺酰胺
A metabolite of asulam and sulfanilamide