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Home >> Signaling Pathways >> Proteases >> Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for  Drug Metabolite

  1. Cat.No. 产品名称 Information
  2. GC62152 Homovanillyl alcohol

    高香草醇

     Homovanillyl alcohol 是羟基酪醇的生物代谢产物。Hydroxytyrosol 是原始橄榄油 (VOO) 和葡萄酒中存在的一种酚类化合物。Homovanillyl alcohol 可保护红细胞 (RBCs) 免受氧化损伤，并对心血管疾病具有保护作用。
  3. GC62033 3α-Hydroxy pravastatin sodium

    3Α-羟基普伐他汀钠

     A metabolite of pravastatin
  4. GC61864 DL-Laudanosine DL-Laudanosine 是 Atracurium 和 Cisatracurium 的代谢物，可透过血脑屏障，引起兴奋和癫痫发作。
  5. GC61813 O-Desmethyl Mebeverine alcohol hydrochloride

    Mebeverine metabolite O-desmethyl Mebeverine alcohol hydrochloride

     O-DesmethylMebeverinealcoholhydrochloride是Mebeverine的代谢物，Mebeverine是一种有效的α1受体(α1repector)抑制剂，用作消化道的一种解痉药。
  6. GC61536 Beclomethasone 17-propionate

    9Α-氯-16Β-甲基孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17-丙酸酯,Beclomethasone-17-monopropionate; 17-BMP

     Beclomethasone17-propionate(Beclomethasone-17-monopropionate)是Beclomethasonedipropionate的活性代谢产物，是糖皮质激素受体(GR)激动剂。Beclomethasone17-propionate对GR的亲和力比Beclomethasonedipropionate高。Beclomethasone17-propionate有效抑制慢性阻塞性肺疾病(COPD)肺巨噬细胞中细胞因子的产生。
  7. GC61478 N-Desmethyl Pimavanserin

    N-去甲基匹莫范色林; AC-279

     N-DesmethylPimavanserin是Pimavanserin的活性代谢物。Pimavanserin是选择性的5-HT2A受体反向激动剂，pIC50和pKd分别为8.73和9.3。
  8. GC48804 N-desmethyl Olanzapine

    N-去甲基奥氮平

     A major metabolite of olanzapine
  9. GC48721 6-O-Demethyl Griseofulvin

    6-Demethylgriseofulvin

     A metabolite of griseofulvin
  10. GC48720 Griseofulvic Acid

    (±)-Griseofulvic Acid

     A metabolite of griseofulvin
  11. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine
  12. GC48611 Ambroxol-d5

    盐酸氨溴索D5

     An internal standard for the quantification of ambroxol
  13. GC48493 PCI 45227

    依鲁替尼代谢物,PCI-45227

     An active metabolite of ibrutinib
  14. GC48461 rac-trans-4-hydroxy Glyburide

    4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide

     An active metabolite of glyburide
  15. GC48457 3-keto Fusidic Acid

    3-酮基夫西地酸(欧洲药典标准品)

     An active metabolite of fusidic acid
  16. GC47923 Paraxanthine-d6

    1,7-Dimethylxanthine-d6

     An internal standard for the quantification of paraxanthine
  17. GC47826 Omeprazole sulfone-d3

    OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3

     An internal standard for the quantification of omeprazole sulfone
  18. GC47757 N-Desmethylclozapine-d8

    Norclozapine-d8; Desmethylclozapine-d8; Normethylclozapine-d8

     An internal standard for the quantification of N-desmethylclozapine
  19. GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin
  20. GC47746 NAP 226-90

    3-(1-(S)-(N,N-二甲基氨基)乙基)苯酚

     A metabolite of rivastigmine
  21. GC47735 N-acetyl Desethylchloroquine-d4

    N-acetyl-(mono) Desethylchloroquine

     An internal standard for the quantification of N-acetyl desethylchloroquine
  22. GC47320 Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)

    17α-Ethynylestradiol 3-Glucuronide

     A metabolite of ethynyl estradiol
  23. GC47196 Desloratadine-d4

    Sch34117-d4

     An internal standard for the quantification of desloratadine
  24. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  25. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  26. GC47040 Carebastine-d5

    卡依巴司丁 d5

     An internal standard for the quantification of carebastine
  27. GC46583 3-Amino-2,6-Piperidinedione

    3-氨基-2,6-哌啶二酮

     An active metabolite of (±)-thalidomide
  28. GC46539 2-Chloroadenine

    2-氯-6-氨基嘌呤

     A heterocyclic building block
  29. GC46508 2',2'-Difluoro-2'-deoxyuridine

    2'-脱氧-2',2'-二氟尿嘧啶核苷

     An active metabolite of gemcitabine
  30. GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
  31. GC46387 1,3,7-Trimethyluric Acid-d9

    TMU-d9, 8-oxo Caffeine-d9

     An internal standard for the quantification of 1,3,7-trimethyluric acid
  32. GC46284 (±)-Cotinine-d3

    氘代甲基可替宁,(±)-Cotinine-d3; (Rac)-NIH-10498-d3

     An internal standard for the quantification of cotinine
  33. GC61353 Trimethoprim N-oxide

    Trimethoprim 1-N-oxide

     TrimethoprimN-oxide(Trimethoprim1-N-oxide)属于人尿代谢物。TrimethoprimN-oxide是通过氧化嘧啶环中的氮原子生成的。TrimethoprimN-oxide主要由CYP1A2在人肝微粒体中形成。
  34. GC61182 Phosphoramide mustard (cyclohexanamine)

    NSC 69945, PMC

     An alkylating agent and active metabolite of cyclophosphamide
  35. GC61165 Paeoniflorgenin

    芍药苷元

     Paeoniflorgenin是Paeoniflorin的去糖基化代谢产物。
  36. GC61147 O-desmethyl Mebeverine acid

    美贝维林去甲基苯甲酸,Mebeverine metabolite O-desmethyl Mebeverine acid

     A metabolite of mebeverine
  37. GC61137 Nordoxepin D3 hydrochloride

    Desmethyldoxepin-d3 hydrochloride

     NordoxepinD3hydrochloride(DesmethyldoxepinD3hydrochloride)是Nordoxepinhydrochloride的氘代物。Nordoxepinhydrochloride是Doxepinhydrochloride的活性代谢产物，Doxepinhydrochloride具有口服活性和抗抑郁作用。
  38. GC61115 N-Desethyl Oxybutynin D5 hydrochloride N-DesethylOxybutyninD5hydrochloride是N-DesethylOxybutyninhydrochloride的氘代物。N-DesethylOxybutynin是Oxybutynin的活性代谢产物。Oxybutynin是一种抗胆碱能药，抑制电压依赖型K+通道。
  39. GC61037 Mebeverine acid

    美贝维林盐酸盐,Mebeverine metabolite Mebeverine acid

     A metabolite of mebeverine
  40. GC60920 Hydroxyhexamide

    (±)-Hydroxyhexamid

     Hydroxyhexamide is a pharmacologically active metabolite of acetohexamide, which is a sulfonylurea hypoglycemic agent.
  41. GC60833 FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
  42. GC60831 Ezetimibe phenoxy glucuronide

    依泽替米贝葡糖苷酸; Ezetimibe glucuronide; Ezetimibe β-D-glucuronide

     Ezetimibephenoxyglucuronide(Ezetimibeglucuronide)是Ezetimibe的活性代谢物，具有抗高脂蛋白血症效果。Ezetimibe是有效的胆固醇吸收抑制剂。
  43. GC60591 Apovincaminic acid hydrochloride salt Apovincaminicacidhydrochloridesalt是Vinpocetine(VP)的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminicacidhydrochloridesalt具有神经保护作用。
  44. GC60541 8-Demethyl Ivabradine

    8-去甲基伊伐布雷定

     8-DemethylIvabradine是Ivabradine的一个代谢物。Ivabradine是具有口服活性的，超极化激活的环核苷酸门控离子通道(HCN)通道阻滞剂。
  45. GC60523 4-Methylamino antipyrine hydrochloride

    安乃近杂质C

     An active metabolite of metamizole
  46. GC60517 4-Hydroxyatomoxetine

    4'-羟基托莫西汀

     A metabolite of atomoxetine
  47. GC60500 3'-Hydroxy Repaglinide D5 3'-HydroxyRepaglinideD5是3'-HydroxyRepaglinide的氘代物。3'-HydroxyRepaglinide是Repaglinide的主要CYP2C8代谢产物。
  48. GC60474 2-Hydroxy atorvastatin lactone

    O-羟基阿伐他汀内酯

     2-Hydroxyatorvastatinlactone是Atorvastatin的代谢产物。2-Hydroxyatorvastatinlactone是一种口服活性HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。
  49. GC60427 (Z)-10-Hydroxynortriptyline

    Z-10-羟基去甲替林

     An active metabolite of amitriptyline and nortriptyline
  50. GC60419 (S)-O-Desmethyl Venlafaxine N-Oxide

    S-O-去甲-文拉法辛N-氧化物

     (S)-O-DesmethylVenlafaxineN-Oxide是(S)-O-DesmethylVenlafaxine的N-氧化物。O-DesmethylVenlafaxine是Venlafaxine的活性代谢产物。Venlafaxine是5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)类的抗抑郁剂。
  51. GC60410 (Rac)-3′-Hydroxy simvastatin

    辛伐他汀杂质

     (Rac)-3′-Hydroxysimvastatin是一种Simvastatin代谢物。Simvastatin是一种竞争性的HMG-CoA还原酶抑制剂，Ki值为0.2nM。

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