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Home >> Signaling Pathways >> Proteases >> Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for  Drug Metabolite

  1. Cat.No. 产品名称 Information
  2. GC60399 (E)-10-Hydroxynortriptyline

    E-10-OH-NT

     An active metabolite of amitriptyline and nortriptyline
  3. GC60367 Tofacitinib metabolite-1

    托法替尼杂质

     Tofacitinib metabolite-1 是 Tofacitinib 的代谢物, JAK 抑制剂。Tofacitinib metabolite-1 可用于 Tofacitinib 的药动力学和代谢研究。
  4. GC60181 GS-704277

    An intermediate alanine metabolite of remdesivir
  5. GC60132 Desmethylnortriptyline

    去甲基去甲替林

     Desmethylnortriptyline 是 Nortriptyline 的代谢产物。Nortriptyline 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢产物，用于缓解抑郁症症状。
  6. GC60124 DCBA DCBA是一种驱虫剂N-N-diethyl-meta-toluamide(DEET)的代谢产物。尿液中DCBA的浓度可以评估DEET的暴露程度。
  7. GC39841 3,4-Dehydro Cilostazol

    西洛他唑杂质B,OPC-13015

     An active metabolite of cilostazol
  8. GC39757 Etilevodopa hydrochloride

    L-3,4-二羟基苯丙氨酸乙酯盐酸盐,L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride

     Etilevodopa (L-Dopa ethyl ester) hydrochloride 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa hydrochloride 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。
  9. GC39611 3'-Hydroxy Repaglinide

    瑞格列奈杂质

     3'-Hydroxy Repaglinide 是 Repaglinide 的主要 CYP2C8 代谢产物。Repaglinide 是氨基甲酰甲基苯甲酸 (CMBA) 衍生物，可作用于 II 型糖尿病。
  10. GC39415 OR-1896

    左西孟旦杂质

     OR-1896 是 Levosimendan 的活性长寿代谢产物。OR-1896 是一种高选择性磷酸二酯酶 (PDE III) 抑制剂，是一种功能强大的血管扩张剂。OR-1896 可以打开 ATP 敏感的 K+ 通道，并具有 Ca2+ 致敏作用。OR-1896 可减轻心肌细胞的凋亡，心脏重塑和心肌炎症。
  11. GC39404 Mebeverine alcohol

    酒美贝维林,Mebeverine metabolite Mebeverine alcohol

     Mebeverine alcohol是Mebeverine的代谢物。
  12. GC39373 Desmethyl ferroquine

    SSR97213

     Desmethyl ferroquine (SSR97213) 是 Ferroquine 的主要活性代谢产物。Ferroquine 是一种抗疟剂。Desmethyl ferroquine 显著抑制对 Chloroquine 敏感的和耐 Chloroquine 的恶性疟原虫菌株 P. falciparum。
  13. GC39307 4-Methylamino antipyrine

    4-(甲氨基)安替比林

     An active metabolite of metamizole
  14. GC39251 Cinacalcet metabolite M4

    3-三氟甲基苯丙胺

     Cinacalcet metabolite M4 是 Cinacalcet 的代谢物。Cinacalcet 是一种可口服的 Ca receptor (CaR) 激动剂，用于心血管疾病。
  15. GC39119 Isonicotinic acid

    异烟酸

     Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.
  16. GC38931 N-Desmethyltamoxifen hydrochloride

    N-去甲基三苯氧胺盐酸盐

     N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 ?M.
  17. GC38903 Deslanoside

    去乙酰西地兰; Deacetyllanatoside C; Desacetyllanatoside C

     A cardiac glycoside
  18. GC45969 6β-hydroxy Eplerenone

    依普利酮6-BETA-羟基类似物

     A major metabolite of eplerenone
  19. GC38779 Etilevodopa

    左旋多巴乙酯,L-DOPA ethyl ester; Levodopa ethyl ester

     Etilevodopa (L-Dopa ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。
  20. GC45687 Dasatinib N-oxide

    达沙替尼N氧化物；达沙替尼杂质

     A major metabolite of dasatinib
  21. GC45650 Des(benzylpyridyl) Atazanavir

    Atazanavir metabolite M1

     A metabolite of atazanavir
  22. GC38660 Megestrol

    甲地孕酮

     Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.
  23. GC38382 CNDAC hydrochloride CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。
  24. GC45580 Tizoxanide-d4

    替唑尼特 D4

     An internal standard for the quantification of tizoxanide
  25. GC45508 MEGX (hydrochloride)

    去乙基利多卡因

     An active metabolite of lidocaine
  26. GC45449 Erythromycylamine

    (9S)-红霉胺

     A macrolide antibiotic
  27. GC45390 Benazepril Acyl-β-D-Glucuronide

    Benazapril Glucuronide

     A metabolite of benazepril
  28. GC45385 Ara-G

    9-Β-D-糖呋喃鸟嘌呤

     An anticancer nucleoside analog
  29. GC37830 Trimethoprim 3-oxide

    Trimethoprim 3-N-oxide

     Trimethoprim 3-oxide 为一种三甲氧苄二氨嘧啶的初级代谢物。
  30. GC37820 Trans (2,3)-Dihydrotetrabenazine

    四苯喹嗪杂质,(2R,3R,11bR)-rel-Dihydrotetrabenazine; (2R,3R,11bR)-rel-DHTBZ

     Trans (2,3)-Dihydrotetrabenazine， 是抗精神病药物Tetrabenazine的体内代谢物，能够抑制囊泡单胺转运体 2 (VMAT2)。
  31. GC37542 Ritonavir metabolite

    利托那韦代谢物; Desthiazolylmethyloxycarbonyl Ritonavir

     Ritonavir metabolite 是抗病毒抑制剂 Ritonavir 的代谢物。
  32. GC37058 Quetiapine sulfoxide hydrochloride

    喹硫平亚砜盐酸盐; Quetiapine S-oxide hydrochloride

     Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。
  33. GC37057 Quetiapine sulfoxide dihydrochloride

    喹硫平亚砜双盐酸盐; Quetiapine S-oxide dihydrochloride

     Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。
  34. GC37056 Quetiapine sulfoxide

    喹硫平磺酸盐,Quetiapine S-oxide

     Quetiapine sulfoxide (Quetiapine S-oxide) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。
  35. GC36737 Nicotinamide N-oxide

    烟酰胺-N-氧化物

     A metabolite of nicotinamide
  36. GC36589 Methotrexate metabolite

    DAMPA

     Methotrexate metabolite (DAMPA)，是 Methotrexate 的活性代谢产物。 Methotrexate 是一种叶酸 (folic acid) 拮抗剂，广泛用作免疫抑制剂和化学治疗剂。
  37. GC36304 IMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.
  38. GC36058 Flumazenil acid

    4H-咪唑并[1,5-A][1,4]苯并二氮杂环庚烷-3-甲酸,8-氟-5,6-二氢-5-甲基-6-氧代-,Ro 15-3890

     Flumazenil acid 是 Flumazenil 的一种代谢产物。Flumazenil 是一种 GABAA 受体拮抗剂。
  39. GC35990 Endoxifen hydrochloride

    因多昔芬盐酸盐

     Endoxifen hydrochloride 是 Tamoxifen 的活性代谢物，是有效的雌激素受体 (estrogen receptor) 拮抗剂。
  40. GC35780 Cycloguanil

    环氯胍

     Cycloguanil hydrochloride, an active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
  41. GC35295 Allopurinol riboside

    别嘌呤醇核糖苷

     A ribonucleoside
  42. GC35219 Abiraterone metabolite 1

    3β-OH-5α-Abi

     Abiraterone metabolite 1 是 abiraterone 的 5β-还原代谢物。Abiraterone 是一种甾体药物，可抑制 CYP17A1，阻断雄激素的合成，延长前列腺癌的生存期。
  43. GC35090 2-Hydroxy atorvastatin calcium salt

    2-羟基阿托伐他汀钙盐

     An active metabolite of atorvastatin
  44. GC35079 24, 25-Dihydroxy VD2

    24,25-二羟基维他命 D2; 24,25-Dihydroxy vitamin D2

    24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物，是合成的维生素D类似物。
  45. GC45252 (-)-Sitagliptin Carbamoyl Glucuronide

    BETA-D-吡喃葡萄糖醛酸1-[N-[(1R)-3-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-A]吡嗪-7(8H)-基]-3-氧代-1-[(2,4,5-三氟苯基)甲基]丙基]氨基甲酸酯]

     A minor phase II metabolite of (–)-sitagliptin
  46. GC45208 α-hydroxy Metoprolol

    Α-羟基美托洛尔

     An active metabolite of metoprolol
  47. GC45151 Voriconazole N-oxide

    伏立康唑N-氧化物

     A major metabolite of voriconazole
  48. GC45144 Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)

    维达列汀羧基酸代谢物三氟醋酸盐

     A major metabolite of vildagliptin
  49. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

     A metabolite of valproic acid
  50. GC45020 Tetrachlorohydroquinone

    四氯氰醌

     A metabolite of pentachlorophenol
  51. GC45012 Tenofovir diphosphate (sodium salt)

    PMPApp, TFV-DP

     An HIV reverse transcriptase and HBV polymerase inhibitor

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