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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase(脂氧合酶)

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products for  Lipoxygenase

  1. Cat.No. 产品名称 Information
  2. GC74159 MK-0731 MK-0731是一种选择性、非竞争性和变构驱动蛋白纺锤体蛋白（KSP）抑制剂，IC50为2.2 nM，pKa为7.6。
  3. GC72794 Flobufen

    VUFB 16066

     Flobufen（VUFB 16066）是一种非甾体抗炎药和环氧化酶（COX）和5-脂氧合酶（5-LOX）抑制剂。
  4. GC91613 FerroLOXIN-1 FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.
  5. GC91594 LYS-006 (hydrochloride) LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.
  6. GC70448 MLS000545091 MLS000545091是一种有效的选择性脂氧合酶-2（LOX-2）抑制剂，对h15-LOX-2的IC50值为2.6μM。
  7. GC70263 Tebufelone Tebufelone（NE-11740）是一种非甾体抗炎药（NSAID），是一种选择性双COX-2/5-脂氧合酶抑制剂。
  8. GC26233 Docosahexaenoic Acid-d5

    C22:6 n-3-d5 C22:6(4Z,7Z,10Z,13Z,16Z,19Z)-d5 Cervonic Acid-d5 DHA-d5 4,7,10,13,16,19-Docosahexaenoic Acid-d5

    Docosahexaenoic acid-d5 (DHA-d5) is intended for use as an internal standard for the quantification of DHA (Item No. 90310) by GC- or LC-MS.
  9. GC90652 12-oxo-9(Z)-Dodecenoic Acid

    12-keto-9Z-Dodecenoic Acid, 12-oxo-9-cis-Dodecenoic Acid

    亚油酸和亚麻酸的代谢产物。
  10. GC90533 (-)-Pinoresinol

    一种具有多种生物活性的木脂素
  11. GC69434 Masoprocol

    meso-Nordihydroguaiaretic acid; meso-NDGA

     Masoprocol (meso-Nordihydroguaiaretic acid) 是一种有效且具有口服活性的脂氧合酶 (lipoxygenase) 抑制剂。Masoprocol 显示出抗高血糖活性。 Masoprocol 降低体内葡萄糖浓度和肝脏甘油三酯浓度。Masoprocol具有研究II型糖尿病的潜力。
  12. GC69335 KKII5

    4,6-二苯基-1,2,3,4-四氰嘧啶-2-硫

     KKII5 是一种有效的脂氧合酶 LOX-1 抑制剂，IC50 为 19 μM。KKII5 抑制脂质过氧化。
  13. GC68641 ALOX15-IN-1 ALOX15-IN-1 (compound 8b) 是一种有效且选择性的兔和人 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂，对 ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA) 的 IC50 分别为 0.04 和 2.06 μM。
  14. GC52413 5-Aminosalicylic Acid-d7

    5-ASA-d7, Mesalamine-d7, Mesalazine-d7

     An internal standard for the quantification of 5-aminosalicylic acid
  15. GC66031 5-LOX-IN-1 5-LOX-IN-1 (compound 2b) 是 5-Lipoxygenase (5-LOX) 的抑制剂，IC50 值为 2.3 μM。5-LOX-IN-1 可用于癌症的研究。
  16. GC64621 4-Nitrocatechol

    4-硝基儿茶酚

     4-Nitrocatechol 是一种有效的脂氧合酶 (lipoxygenase) 抑制剂。
  17. GC52105 Montelukast

    孟鲁司特,MK0476 free base

     A CysLT1 receptor antagonist
  18. GC49894 15(S)-HETE-d8 ethyl ester

    15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester

     An internal standard for the quantification of 15(S)-HETE ethyl ester
  19. GC49849 3-Aminosalicylic Acid

    3-氨基水杨酸

     A salicylic acid derivative
  20. GC49778 Etheroleic Acid A divinyl ether oxylipin
  21. GC49758 CAY10788 A CysLT1 receptor antagonist
  22. GC19933 Leukotriene B4

    [5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸,LTB4; 5(S),12(R)-DiHETE

     A leukotriene involved in inflammation
  23. GC64078 3-O-Acetyl-11-hydroxy-beta-boswellic acid

    3α-O-乙酰基-11α-羟基-β-乳香酸

     3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。
  24. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

    15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

     An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
  25. GC49696 FPL 55712 (sodium salt) A leukotriene receptor antagonist
  26. GC49597 Leukotriene B4-d5

    LTB4-d5

     An internal standard for the quantification of LTB4
  27. GC49590 Docosahexaenoic Acid 1,2,3,4-13C

    C22:6 n-3 1,2,3,4-13C, C22:6(4Z,7Z,10Z,13Z,16Z,19Z) 1,2,3,4-13C, Cervonic Acid 1,2,3,4-13C, DHA 1,2,3,4-13C

     An internal standard for the quantification of DHA
  28. GC49386 Tepoxalin

    替泊沙林

     A dual inhibitor of COX and 5-LO
  29. GC49364 3-Hydroxycoumarin

    3-羟基香豆素

     A coumarin with diverse biological activities
  30. GC49356 17(S)-HDoTE

    17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid

     A metabolite of adrenic acid
  31. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine
  32. GC48993 Protectin D1-d5

    Neuroprotectin D1-d5, NPD1-d5, PD1-d5

     An internal standard for the quantification of protectin D1
  33. GC48972 Resolvin E2

    (-)-Resolvin E2

     A specialized pro-resolving mediator
  34. GC62040 Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

    CDC

     Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 是一种有效的 12/15 脂氧合酶 (12/15-LO) 抑制剂。Cinnamyl-3,4-dihydroxy-α-cyanocinnamate 可用于研究1型糖尿病。
  35. GC48893 Carbazomycin B A bacterial metabolite with diverse biological activities
  36. GC48850 Carbazomycin C A bacterial metabolite with diverse biological activities
  37. GC48739 (±)15-HETE-d8

    (±)15-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 15-HETE
  38. GC48738 (±)12-HETE-d8

    (±)12-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 12-HETE
  39. GC48659 Umbelliprenin

    7-Farnesyloxycoumarin

     A prenylated coumarin with diverse biological activities
  40. GC48267 Zileuton-d4

    齐留通 d4

     An internal standard for the quantification of zileuton
  41. GC48045 Resolvin E4

    RvE4

     A specialized pro-resolving mediator
  42. GC48044 Resolvin E1-d4

    RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4

     A neuropeptide with diverse biological activities
  43. GC48043 Resolvin D3-d5

    RvD3-d5

     A neuropeptide with diverse biological activities
  44. GC48042 Resolvin D2-d5

    RvD2-d5

     An internal standard for the quantification of RvD2
  45. GC48041 Resolvin D1-d5

    RvD1-d5

     An internal standard for the quantification of RvD1
  46. GC48035 RCTR1

    Resolvin Glutathione Conjugate in Tissue Regeneration 1, Resolvin Sulfido Conjugate 1

     A specialized pro-resolving mediator
  47. GC47716 Myxochelin A

    (S)-Myxochelin A

     A microbial metabolite with diverse biological activities
  48. GC47701 Montelukast-d6 (sodium salt)

    MK-476-d6

     A neuropeptide with diverse biological activities
  49. GC47599 Maresin 2-d5

    13R,14S-diHDHA-d5, 13R,14S-dihydroxy Docosahexaenoic Acid-d5, MaR2-d5

     A neuropeptide with diverse biological activities
  50. GC47598 Maresin 1-d5

    7(R)-MaR1-d5, 7(R)-Maresin 1-d5

     A neuropeptide with diverse biological activities
  51. GC47575 Loratadine-d5

    五氘代氯雷他定,Loratidine-d5; SCH 29851-d5

     An internal standard for the quantification of loratadine

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