Mitochondrial Metabolism(线粒体代谢)

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Products for Mitochondrial Metabolism

Cat.No. 产品名称 Information
GC19941 DL-Leucic Acid
GC40539 (±)12(13)-EpOME
(±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid
The 12,13-cis epoxide form of linoleic acid
GC40801 (±)9(10)-DiHOME
(±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸
A diol form of (±)9(10)-EpOME
GC14049 (-)-Epigallocatechin gallate (EGCG)
(-)-表没食子儿茶素没食子酸酯,EGCG
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
GC41721 (R)-α-Lipoic Acid
硫辛酸; (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid
A cyclic disulfide antioxidant
GC18596 (±)-2-propyl-4-Pentenoic Acid
2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
A metabolite of valproic acid
GC19528 1,4-Benzoquinone
对苯醌
A toxic metabolite of benzene
GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade)
10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF
A formyl donor and cofactor
GC46451 16F16 A PDI inhibitor
GC90815 2',3'-cyclic NADP+ (sodium salt)
2′,3′-cNADP+, β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

一种CNP的底物。
GC90803 2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)
ddATP, Dideoxyadenosine-5'-triphosphate

一种反转录酶抑制剂，是ddA和ddI的活性代谢产物。
GC42193 2-Thenoyltrifluoroacetone
2-噻吩甲酰三氟丙酮,HTTA; TTA; TTFA
An inhibitor of respiration
GC49849 3-Aminosalicylic Acid
3-氨基水杨酸
A salicylic acid derivative
GC45615 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)
DL-3-hydroxy-3-methylglutaryl-CoA, HMG-CoA, Hydroxymethylglutaryl-CoA
A neuropeptide with diverse biological activities
GC46599 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)
DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3
A neuropeptide with diverse biological activities
GC42351 4-carboxy TEMPO
4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基
A spin label
GC49722 4-CF3-TPP-DC
4-CF3-Triphenylphosphonium-DC
An inert mitochondriotropic carrier
GC41310 5-Octyl-α-ketoglutarate
αKG octyl ester
A cell-permeable form of α-ketoglutarate
GC46779 Acequinocyl
灭螨醌
A naphthoquinone acaricide
GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA
A precursor to HMG-CoA
GC46789 Acetyl-L-carnitine-d3 (chloride)
O-Acetyl-L-carnitine-d3-1 hydrochloride
An internal standard for the quantification of L-acetylcarnitine
GC19021 Adjudin
男用口服避孕药,AF-2364
A derivative of lonidamine
GC42742 ADT-OH
5-(4-羟基苯基)-3H-1,2-二硫杂环戊烯-3-硫酮,5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1
A synthetic H₂S donor used in making chimeras
GC46812 Aflatoxin G1-13C17
黄曲霉毒素G1-(全碳-13)
An internal standard for the quantification of aflatoxin G₁
GC46814 Aflatoxin M1-13C17
AFM1-13C17
A neuropeptide with diverse biological activities
GC35262 Afzelin
阿福豆苷,Kaempferol-3-O-rhamnoside
A polyphenolic glycoside flavone with diverse biological activities
GC63642 Agaric acid
落叶松蕈酸,Agaricinic Acid
Agaric acid (Agaricinic Acid) 来自真菌部落的 Polyporus officinalis 和 Polyporus igniarius。Agaric acid 通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。Agaric acid 可促进积累的 Ca2+ 流出，跨膜电位的破坏和线粒体肿胀。Agaric acid 用于调节脂类代谢。
GC18437 Alternariol monomethyl ether
交链孢霉甲基醚
A mycotoxin
GC18274 Amiprofos-methyl
甲基胺草磷,BAY-NTN 6867
An herbicide
GC42818 Antimycin A1
抗黴素A1
An active component of the antimycin A antibiotic complex
GC18621 Antimycin A2
丁酸-3-[(3-甲酰-2-羟基苯甲酰基)氨基]-8-己基-2,6-二甲基-4,9-二氧-1,5-二酰-7-酯
An active component of the antimycin A antibiotic complex
GC42820 Antimycin A4
抗霉素A4
An active component of the antimycin A antibiotic complex
GC42821 AP219 A control compound for AP39
GC42823 AP39 A mitochondrial H₂S donor
GC42846 Arachidonoyl-L-carnitine (chloride)
C20:4 Carnitine

A C20:4 acylcarnitine
GC46883 AS-2077715 An inhibitor of fungal complex III
GC31432 Asp-AMS Asp-AMS是天冬氨酸腺苷酸的一个类似物，是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂，也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。
GC42874 Aureothin
金链菌素
A polyketide antibiotic that inhibits oxidoreductase
GC40677 Avenaciolide
(±)-Avenaciolide
A fungal metabolite
GC18580 B355252 A neuroprotective agent
GC49901 BAY-179 A mitochondrial complex I inhibitor
GC49403 Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone
GC49318 Benzovindiflupyr A fungicide
GC41252 BI-6C9 An inhibitor of tBid-mediated apoptosis
GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt)
DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)
A Bim-derived peptide
GC18408 BML-278
DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
An activator of SIRT1, SIRT2, and SIRT3
GC46943 Boscalid
啶酰菌胺
A broad-spectrum carboxamide fungicide
GC42978 Bromamphenicol A dibrominated derivative of chloramphenicol
GC43030 C16 dihydro Ceramide (d18:0/16:0)
Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine
A bioactive sphingolipid
GC91157 C18
一种共价的GPX4抑制剂