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Mitochondrial Metabolism(线粒体代谢)

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Products for  Mitochondrial Metabolism

  1. Cat.No. 产品名称 Information
  2. GC19941 DL-Leucic Acid
  3. GC40539 (±)12(13)-EpOME

    (±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid

    The 12,13-cis epoxide form of linoleic acid
  4. GC40801 (±)9(10)-DiHOME

    (±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸

    A diol form of (±)9(10)-EpOME
  5. GC14049 (-)-Epigallocatechin gallate (EGCG)

    (-)-表没食子儿茶素没食子酸酯,EGCG

    (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
  6. GC41721 (R)-α-Lipoic Acid

    硫辛酸; (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid

    A cyclic disulfide antioxidant
  7. GC18596 (±)-2-propyl-4-Pentenoic Acid

    2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA

    A metabolite of valproic acid
  8. GC19528 1,4-Benzoquinone

    对苯醌

    A toxic metabolite of benzene
  9. GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade)

    10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF

    A formyl donor and cofactor
  10. GC46451 16F16 A PDI inhibitor
  11. GC90815 2',3'-cyclic NADP+ (sodium salt)

    2′,3′-cNADP+, β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

    一种CNP的底物。

  12. GC90803 2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

    ddATP, Dideoxyadenosine-5'-triphosphate

    一种反转录酶抑制剂,是ddA和ddI的活性代谢产物。

  13. GC42193 2-Thenoyltrifluoroacetone

    2-噻吩甲酰三氟丙酮,HTTA; TTA; TTFA

    An inhibitor of respiration
  14. GC49849 3-Aminosalicylic Acid

    3-氨基水杨酸

    A salicylic acid derivative
  15. GC45615 3-hydroxy-3-methylglutaryl Coenzyme A (sodium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA, HMG-CoA, Hydroxymethylglutaryl-CoA

    A neuropeptide with diverse biological activities
  16. GC46599 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)

    DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3

    A neuropeptide with diverse biological activities
  17. GC42351 4-carboxy TEMPO

    4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基

    A spin label
  18. GC49722 4-CF3-TPP-DC

    4-CF3-Triphenylphosphonium-DC

    An inert mitochondriotropic carrier
  19. GC41310 5-Octyl-α-ketoglutarate

    αKG octyl ester

    A cell-permeable form of α-ketoglutarate
  20. GC46779 Acequinocyl

    灭螨醌

    A naphthoquinone acaricide
  21. GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)

    Acetoacetyl-CoA

    A precursor to HMG-CoA
  22. GC46789 Acetyl-L-carnitine-d3 (chloride)

    O-Acetyl-L-carnitine-d3-1 hydrochloride

    An internal standard for the quantification of L-acetylcarnitine
  23. GC19021 Adjudin

    男用口服避孕药,AF-2364

    A derivative of lonidamine
  24. GC42742 ADT-OH

    5-(4-羟基苯基)-3H-1,2-二硫杂环戊烯-3-硫酮,5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1

    A synthetic H2S donor used in making chimeras
  25. GC46812 Aflatoxin G1-13C17

    黄曲霉毒素G1-(全碳-13)

    An internal standard for the quantification of aflatoxin G1
  26. GC46814 Aflatoxin M1-13C17

    AFM1-13C17

    A neuropeptide with diverse biological activities
  27. GC35262 Afzelin

    阿福豆苷,Kaempferol-3-O-rhamnoside

    A polyphenolic glycoside flavone with diverse biological activities
  28. GC63642 Agaric acid

    落叶松蕈酸,Agaricinic Acid

    Agaric acid (Agaricinic Acid) 来自真菌部落的 Polyporus officinalis 和 Polyporus igniarius。Agaric acid 通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。Agaric acid 可促进积累的 Ca2+ 流出,跨膜电位的破坏和线粒体肿胀。Agaric acid 用于调节脂类代谢。
  29. GC18437 Alternariol monomethyl ether

    交链孢霉甲基醚

    A mycotoxin
  30. GC18274 Amiprofos-methyl

    甲基胺草磷,BAY-NTN 6867

    An herbicide
  31. GC42818 Antimycin A1

    抗黴素A1

    An active component of the antimycin A antibiotic complex
  32. GC18621 Antimycin A2

    丁酸-3-[(3-甲酰-2-羟基苯甲酰基)氨基]-8-己基-2,6-二甲基-4,9-二氧-1,5-二酰-7-酯

    An active component of the antimycin A antibiotic complex
  33. GC42820 Antimycin A4

    抗霉素A4

    An active component of the antimycin A antibiotic complex
  34. GC42821 AP219 A control compound for AP39
  35. GC42823 AP39 A mitochondrial H2S donor
  36. GC42846 Arachidonoyl-L-carnitine (chloride)

    C20:4 Carnitine​

    A C20:4 acylcarnitine

  37. GC46883 AS-2077715 An inhibitor of fungal complex III
  38. GC31432 Asp-AMS Asp-AMS是天冬氨酸腺苷酸的一个类似物,是aspartyl-tRNA合成酶(aspartyl-tRNAsynthetase)的一个抑制剂,也是线粒体酶(mitochondrialenzyme)的强效竞争性抑制剂。
  39. GC42874 Aureothin

    金链菌素

    A polyketide antibiotic that inhibits oxidoreductase
  40. GC40677 Avenaciolide

    (±)-Avenaciolide

    A fungal metabolite
  41. GC18580 B355252 A neuroprotective agent
  42. GC49901 BAY-179 A mitochondrial complex I inhibitor
  43. GC49403 Benzarone

    苯扎隆,Fragivix

    An active metabolite of benzbromarone
  44. GC49318 Benzovindiflupyr A fungicide
  45. GC41252 BI-6C9 An inhibitor of tBid-mediated apoptosis
  46. GC72916 Biguanide Biguanide是一种口服活性降糖剂。
  47. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt)

    DMRPEIWIAQELRRIGDEFNAYYARR-OH, Bims (51-76)

    A Bim-derived peptide
  48. GC18408 BML-278

    DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"

    An activator of SIRT1, SIRT2, and SIRT3
  49. GC46943 Boscalid

    啶酰菌胺

    A broad-spectrum carboxamide fungicide
  50. GC42978 Bromamphenicol A dibrominated derivative of chloramphenicol
  51. GC43030 C16 dihydro Ceramide (d18:0/16:0)

    Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine

    A bioactive sphingolipid

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