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Home >> Signaling Pathways >> Proteases >> Mitochondrial Metabolism

Mitochondrial Metabolism(线粒体代谢)

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Products for  Mitochondrial Metabolism

  1. Cat.No. 产品名称 Information
  2. GC48425 C18 D-threo Ceramide (d18:1/18:0)

    D-threo Cer(d18:1/18:0), D-threo Ceramide (d18:1/18:0), N-octadecanoyl-D-threo-Sphingosine, N-stearoyl-D-threo-Sphingosine

     A synthetic ceramide
  3. GC49806 C18 Ganglioside GD3-d3 (ammonium salt)

    Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3-d3

     An internal standard for the quantification of ganglioside GD3
  4. GC43050 C18 L-erythro Ceramide (d18:1/18:0)

    L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine

     A naturally occurring ceramide
  5. GC43051 C18 L-threo Ceramide (d18:1/18:0)

    N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)

     A synthetic ceramide
  6. GC43052 C18 Phytoceramide (t18:0/18:0)

    N-硬脂酰植物鞘胺醇

     A bioactive sphingolipid
  7. GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)

    Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3

     An internal standard for the quantification of C18 phytoceramide
  8. GC43069 C22 Ceramide (d18:1/22:0)

    C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)

     A bioactive sphingolipid
  9. GC43141 Carboxyatractyloside (potassium salt)

    羧基苍术苷

     An inhibitor of ADP/ATP translocases
  10. GC43195 CAY10703 A stable dichloroacetate derivative
  11. GC47065 CAY10773 A derivative of sorafenib
  12. GC14727 CCCP

    羰基氰化氯苯腙,Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone

     Carbonylcyanide-3-chlorophenylhydrazone (CCCP) 是一种质子载体，可导致线粒体内膜中的质子梯度解偶联，从而抑制 ATP 合成速率。
  13. GC65208 CCI-006 CCI-006 是 MLL-重组白血病细胞的选择性抑制剂和化学增敏剂，通过抑制线粒体呼吸，导致 MLL-重组白血病细胞中不可克服的线粒体去极化和促凋亡的未折叠蛋白反应。
  14. GC90336 cis-6-Hexadecenoic Acid-d19

    C16:1(6Z)-d19, C16:1δ6-d19, C16:1ω10c-d19, Sapienic Acid-d19

    一种用于定量-6-十六烯酸的内部标准
  15. GC45410 cis-6-Hexadecenoic Acid-d19

    C16:1(6Z)-d19, C16:1Δ6-d19, C16:1ω10c-d19, Sapienic Acid-d19

     An internal standard for the quantification of cis-6-hexadecenoic acid
  16. GC47096 Citrinin-13C13

    (–)-Citrinin-13C13, CTN-13C13

     A neuropeptide with diverse biological activities
  17. GC43289 Cochlioquinone B A fungal metabolite
  18. GC47114 Coenzyme A (lithium salt hydrate)

    CoA

     An essential cofactor in enzymatic acetyl transfer reactions
  19. GC43295 Coenzyme A (sodium salt hydrate)

    CoA

     An essential cofactor in enzymatic acetyl transfer reactions
  20. GC47116 Coenzyme Q10-d6

    辅酶Q10-D6,CoQ10-d6; Ubiquinone-10-d6

     An internal standard for the quantification of CoQ10
  21. GC43297 Coenzyme Q2

    辅酶Q2

     A biosynthetic precursor to CoQ10 and an inhibitor of mitochondrial complex I
  22. GC49454 Complex 3 A fluorescent copper complex with anticancer activity
  23. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases
  24. GC91800 CPPA-TPP

    CPPA-Triphenylphosphonium,4-Cyano-4-(phenylcarbonothioylthio)pentanoic Acid-TPP,4-Cyano-4-(phenylcarbonothioylthio)pentanoic-Triphenylphosphonium

     CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).
  25. GC19138 CTPI-2

    2-(4-氯-3-硝基苯基磺酰胺基)苯甲酸

     A mitochondrial citrate transporter inhibitor
  26. GC43345 Cyclohexanoyl Coenzyme A

    CHCoA, Cyclohexanecarboxyl-CoA

     An acyl CoA that contains a cyclohexane group
  27. GC49863 Cytarabine 5′-monophosphate

    ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

     An active metabolite of cytarabine
  28. GC45800 Cytarabine-13C3

    Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3

     A neuropeptide with diverse biological activities
  29. GC25337 D-Carnitine hydrochloride

    (S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride

     D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
  30. GN10072 Daidzin

    大豆苷; Daidzoside; NPI-031D; Daidzein 7-O-glucoside

     Natural isoflavone
  31. GC47176 Decanoyl-Coenzyme A (hydrate)

    Decanoyl-CoA

     A neuropeptide with diverse biological activities
  32. GC47177 Decanoyl-L-carnitine (hydrate)

    CAR 10:0, C10:0 Carnitine, L-Carnitine decanoyl ester, (–)-Decanoylcarnitine, L-Decanoylcarnitine

     A neuropeptide with diverse biological activities
  33. GC47178 Decanoyl-L-carnitine-d3 (chloride)

    癸酰基-L-肉碱-d3

     A neuropeptide with diverse biological activities
  34. GC40538 Decylubiquinone

    癸基泛醌

     An analog of ubiquinone (coenzyme Q10)
  35. GC18869 Deoxyenterocin

    5-Deoxyenterocin

     A bacterial metabolite with diverse biological activities
  36. GC49022 Didanosine-d2

    去羟肌苷 d2

     An internal standard for the quantification of didanosine
  37. GC38620 Dihydrorotenone

    二氢鱼藤酮

     Dihydrorotenone 是一种天然杀虫剂，是一种线粒体 (mitochondrial) 抑制剂。Dihydrorotenone 可能诱发帕金森综合症。Dihydrorotenone 通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡 (apoptosis)
  38. GC43463 DiIC1(5)

    1,1',3,3,3',3'-六甲基吲哚双碳菁碘

     A signal-off fluorescent probe
  39. GC47238 Diquat (bromide)

    敌草快

     An herbicide
  40. GC47239 Diquat-d12 (bromide) A neuropeptide with diverse biological activities
  41. GC47240 Diquat-d4 (bromide) A neuropeptide with diverse biological activities
  42. GC43498 DL-α-Lipoic Acid

    α-硫辛酸; Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid

     An important decarboxylation cofactor and antioxidant
  43. GC47243 DL-Carnitine-d9 (chloride)

    DL-肉碱盐酸盐-D9氘代,DL-Carnitine-d9 chloride

     An internal standard for the quantification of carnitine
  44. GC43543 DNP-INT An electron transport inhibitor in plants
  45. GC18439 Doxorubicinone

    阿霉酮,Adriamycin aglycone; Adriamycinone

     A metabolite of doxorubicin
  46. GC47274 DS44960156 An MTHFD2 inhibitor
  47. GC18992 Duclauxin

    NSC 258308

     An antitumor agent
  48. GC30014 Elamipretide (MTP-131)

    D-精氨酰-2,6-二甲基-L-酪氨酰-L-赖氨酰-L-苯丙氨酰胺,RX-31; SS-31

     Elamipretide (MTP-131) 作为一种水溶性四肽，可以增强细胞 ATP 合成，从而改善电子传输并减少 ROS 的形成。
  49. GC34569 Elamipretide TFA

    ElamipretideTFA(MTP-131TFA;RX-31TFA;SS-31TFA)是一种靶向作用于线粒体内膜的多肽，是心磷脂过氧化物酶(cardiolipinperoxidase)抑制剂。
  50. GC72090 Elamipretide triacetate Elamipretide triacetate（MTP-131三乙酸酯；RX-31三乙酸酯；SS-31三乙酸酯）是Elamipletide的Elamipretide triacetate形式。
  51. GC32858 ER-000444793 ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.

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