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Home >> Signaling Pathways >> Proteases >> MMP

MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for  MMP

  1. Cat.No. 产品名称 Information
  2. GC47117 Colchicine-d6

    秋水仙素 d6

     An internal standard for the quantification of colchicine
  3. GC47042 Carfilzomib-d8

    来那度胺-D8

     An internal standard for the quantification of carfilzomib
  4. GC46890 Atorvastatin-d5 (calcium salt)

    阿托伐他汀 d5 (1/2钙盐)

     An internal standard for the quantification of atorvastatin
  5. GC46854 Anastrozole-d12

    ZD1033-d12

     An internal standard for the quantification of anastrozole
  6. GC46820 AHU377-d4

    AHU-377-d4

     An internal standard for the quantification of AHU377
  7. GC46779 Acequinocyl

    灭螨醌

     A naphthoquinone acaricide
  8. GC46769 Abametapir

    55'-二甲基-2,2-联吡啶

     A building block and an insecticide
  9. GC60860 FSL-1 TFA

    FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection.
  10. GC60114 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
  11. GC39640 GPLGIAGQ TFA

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
  12. GC50353 T 26c disodium salt A selective inhibitor of MMP-13
  13. GC50189 TAPI 0 TAPI 0 是一种 TACE（TNF-α 转化酶；ADAM17）抑制剂，IC50 为 100 nM。
  14. GC46220 SD 2590 (hydrochloride)

    SC-78080

     An MMP inhibitor
  15. GC39134 Isofraxidin

    异嗪皮啶

     Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
  16. GC39095 Isoliquiritin apioside

    芹糖异甘草苷

     Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
  17. GC38929 MMP-9-IN-1 MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM.
  18. GC46026 TMI 1

    WAY-171318

     An ADAM and MMP inhibitor
  19. GC45978 1,10-Phenanthroline (hydrate)

    邻菲罗啉,1,10-Phenanthroline monohydrate

     A metal chelator and inhibitor of metalloproteases
  20. GC38871 XL-784 free base XL-784 free base 是 MMP 的一个选择性抑制剂，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13 的 IC50 值分别约为 1900，0.81，120，10.8，18，0.56 nM。
  21. GC38837 Prinomastat hydrochloride

    AG3340 hydrochloride; KB-R9896 hydrochloride

     An inhibitor of MMP-2, -3, -9, -13, and -14
  22. GC38831 PF-00356231 hydrochloride PF-00356231 hydrochloride 是一种非肽、非锌螯合的基质金属蛋白酶 MMP-12 的配体和抑制剂 (IC50=1.4 μM)。它对 MMP-12 具有特异性并形成 PF-00356231/MMP-12 复合体。PF-00356231 hydrochloride 对 MMP-13、MMP-8、MMP-9、MMP-3 有抑制作用，IC50 分别为 0.00065、1.7、0.98、0.39 μM。
  23. GC45818 Metoclopramide-d3

    甲氧氯普安D3

     An internal standard for the quantification of metoclopramide
  24. GC45440 Doxycycline-d3 (hyclate)

    一种用于量化多西环素的内部标准
  25. GC45398 Captopril-d3

    卡托普利-D3,SQ 14225-d3

     An internal standard for the quantification of captopril
  26. GC45341 4-Amino-6-chloro-1,3-benzenedisulfonamide

    ACB, Chloraminophenamide, 3-Chloroaniline-4,6-disulfonamide, NSC 93772

     A carbonic anhydrase inhibitor
  27. GC36635 MMP3 inhibitor 1 MMP3 inhibitor 1 是一种有效的高选择性 MMP-3 抑制剂，IC50 为 1 nM。
  28. GC36495 Luteolin 7-O-glucuronide

    木犀草素-7-葡萄糖醛酸苷,Luteolin 7-glucuronide

     A flavone with diverse biological activities
  29. GC36491 Lucideric acid A

    赤芝酸 A

     A triterpene with anticancer activity
  30. GC36489 Lucidenic acid C

    赤芝酸 C

     Lucidenic acid C 是从灵芝中分离得到的天然产物，可抑制 PMA 诱导的 MMP-9 活性，对肝癌细胞具有抗侵袭作用。
  31. GC36456 Licoricidin

    甘草西定

     Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。
  32. GC36230 Histatin 5 (TFA)

    富组蛋白5三氟乙酸盐

     Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC50s 分别为 0.57 和 0.25 μM。
  33. GC36137 Ginsenoside F4

    人参皂苷F4

     Ginsenoside F4 (GF4)，人参皂甙，从三七或红参中分离。Ginsenoside F4 (GF4) 通过诱导凋亡 (apoptosis) 对人淋巴细胞瘤 JK 细胞具有抑制作用。Ginsenoside F4 (GF4) 抑制 IL-1β 处理的软骨细胞中基质金属蛋白酶 13 (MMP 13) 的表达，阻断兔软骨组织培养中的软骨损坏，具有防止病变组织的软骨胶原基质分解的治疗潜力。
  34. GC35754 CTTHWGFTLC, CYCLIC CTTHWGFTLC, CYCLIC 是基质金属蛋白酶 MMP-2 和 MMP-9 的环肽抑制剂。
  35. GC35470 Batimastat sodium salt

    (2S,3R)-N-羟基-N'-[(2S)-1-甲基氨基-1-氧代-3-苯基丙-2-基]-3-异丁基-2-(噻吩-2-基硫甲基)丁二酰胺单钠盐,BB-94 sodium salt

     A potent broad spectrum inhibitor of MMPs
  36. GC35377 Apratastat

    N-羟基-4-[[4-[(4-羟基-2-丁炔基)氧基]苯基]磺酰基]-2,2-二甲基-3-硫代吗啉甲酰胺,TMI-005

     An inhibitor of ADAM17 and MMPs
  37. GC35369 Apigenin-7-glucuronide

    芹菜素-7-葡萄糖醛酸,Apigenin 7-O-glucuronide

     Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
  38. GC35300 Aloin(mixture of A&B)

    芦荟苷

     An anthroquinone with diverse biological activities
  39. GC45177 Z-AEVD-FMK

    Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

     A caspase-10 inhibitor
  40. GC45090 Triparanol

    曲帕拉醇,MER-29

     An inhibitor of DHCR24
  41. GC45086 Trigalacturonic Acid

    半乳糖醛酸

     三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。
  42. GC44990 Tanomastat

    (S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸,BAY 12-9566

     An inhibitor of MMP-2, -3, and -9
  43. GC44891 Simeprevir (sodium salt)

    西咪匹韦钠; TMC435 sodium; TMC435350 sodium

     A potent NS3/4A protease inhibitor
  44. GC44441 N-Oleoyl Leucine An N-acyl amide involved in mitochondrial uncoupling
  45. GC44431 nNOS Inhibitor I

    Neuronal Nitric Oxide Synthase, NOS I, ncNOS

     A selective inhibitor of nNOS
  46. GC44341 ND-336 A selective inhibitor of MMP-2, -9, and -14
  47. GC44306 N-acetyl-S-geranylgeranyl-L-Cysteine

    N-乙酰基-S-香叶基香叶基-L-半胱氨酸

     A synthetic substrate for the SAM-dependent methyltransferase
  48. GC44237 MMP-9 Inhibitor I

    Matrix Metalloproteinase-9 Inhibitor I

     An inhibitor of MMP-9
  49. GC44236 MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)

    Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III

     An inhibitor of MMP-2 and MMP-9
  50. GC44214 ML-162 A GPX4 inhibitor
  51. GC44186 Metoclopramide (hydrochloride)

    盐酸甲氧氯普胺

     An orally bioavailable 5-HT3 and D2 receptor antagonist

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