MMP(基质金属蛋白酶)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.

Products for MMP

Cat.No. 产品名称 Information
GC43051 C18 L-threo Ceramide (d18:1/18:0)
N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)
A synthetic ceramide
GC43050 C18 L-erythro Ceramide (d18:1/18:0)
L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine
A naturally occurring ceramide
GC42873 Auraptene
橙皮油素
A coumarin derivative with anti-inflammatory and chemopreventative activity
GC42665 AAF-CMK (trifluoroacetate salt)
NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II
An inhibitor of TPPII
GC41776 1,2,3-Trioleoyl-rac-glycerol
三油酸甘油酯
A triacylglycerol
GC41642 9(E),11(E),13(E)-Octadecatrienoic Acid
β-Eleostearic Acid, β-ESA
A polyunsaturated fatty acid
GC41552 ω-3 Arachidonic Acid
ω3 AA
A rare, natural 20:4 ω-3 polyunsaturated fatty acid
GC41258 Spiroxamine
螺噁茂胺
A fungicide
GC41251 Pirlindole
坡尔吲哚
A selective and reversible MAO-A inhibitor
GC40624 MMP-3 Inhibitor VIII
Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII
A selective inhibitor of MMP-3
GC40538 Decylubiquinone
癸基泛醌
An analog of ubiquinone (coenzyme Q₁₀)
GC40234 Ramipril-d5
雷米普利 d5
An internal standard for the quantification of ramipril
GC40229 (±)-Warfarin-d5
4-羟基-3-[3-氧代-1-(苯基-D5)丁基]-2H-1-苯并吡喃-2-酮,WARF-42-d5; Athrombine-K-d5
An internal standard for the quantification of warfarin
GC40221 Ritonavir-d6
利托那韦 d6
An internal standard for the quantification of ritonavir
GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin
GC33881 Ro 31-9790 (GI4747)
GI4747
Ro 31-9790 (GI4747) 是一种合成金属蛋白酶 (MMP) 抑制剂。
GC33365 BR351 precursor BR351precursor是BR351的前体。BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
GC33330 Cynaropicrin
菜蓟苦素
A sesquiterpene lactone
GC33164 PNU-248686A PNU-248686A是一种新型的基质金属蛋白酶(MMP)抑制剂。
GC32951 Prinomastat (AG3340)
普啉司他; AG3340; KB-R9896
An inhibitor of MMP-2, -3, -9, -13, and -14
GC32938 S 3304 S-3304是一个新型的基质金属蛋白酶(MMP)抑制剂,且对MMP-2和MMP-9有特异的抑制活性。
GC32823 Incyclinide (CMT-3)
CMT-3; COL-3
An inhibitor of MMP-13, MMP-1, and MMP-8
GC32792 JNJ0966 An inhibitor of MMP-9 zymogen activation
GC32758 Isoginkgetin
异银杏素
A biflavonoid inhibitor of pre-mRNA splicing
GC32505 XL-784
XL-784是MMP的一个选择性抑制剂，其对MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别约为1900，0.81，120，10.8，18，0.56nM。
GC32442 BR351 BR351是可渗透血脑屏障的MMP抑制剂，抑制MMP2，MMP8，MMP9，MMP13的IC50分别为4，2，11，50nM。是正电子发射断层扫描成像活化MMP分子的潜在工具。
GC31898 Histatin 5
富组蛋白5
An antimicrobial peptide
GC31862 T-26c A selective inhibitor of MMP-13
GC31734 S-methyl-KE-298 (M-2)
M-2

S-methyl-KE-298 (M-2) 是 KE-298 的活性代谢物。
GC19483 MS-PPOH A potent, selective inhibitor of microsomal CYP450 epoxidase activity
GC19347 TAPI-2
TNF Protease Inhibitor 2
An inhibitor of TACE and MMPs
GC18791 Prostaglandin H1
前列腺素H1
The precursor to all 1-series prostaglandins and thromboxanes
GC18709 D-NMMA (acetate)
NG-单甲基-D-精氨酸醋酸盐
A control compound for studying NOS inhibition
GC18706 SR 9186
ML368
A selective inhibitor of CYP3A4
GC18659 Ribavirin 5'-monophosphate (lithium salt)
利巴韦林5'-单磷酸二锂盐
A potent, broad-spectrum antiviral agent
GC18616 MMP-8 Inhibitor I
Matrix Metalloproteinase-8 Inhibitor I
A selective inhibitor of MMP-8
GC18612 MMP-9/MMP-13 Inhibitor I
Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I
An MMP inhibitor
GC18608 MMP-2/MMP-9 Inhibitor II
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II
A dual inhibitor of MMP-2 and MMP-9
GC18517 Diapocynin An inhibitor of NADPH-oxidase
GC18510 Siccanin
西卡宁
An inhibitor of mitochondrial complex II
GC18359 4-Epianhydrochlortetracycline (hydrochloride)
4-差向四环素盐酸盐
An inhibitor of MMP-9
GC16165 T-5224
T-5224 是一种非肽类小分子 AP-1 抑制剂，特异性抑制 AP-1 与启动子区 AP-1 结合位点的结合，最初开发为抗炎药用于治疗类风湿性关节炎 (RA) 抑制炎症细胞因子和 MMPs 而没有任何副作用。
GC13005 MMP-2 Inhibitor II
Matrix Metalloproteinase-2 Inhibitor II
A selective MMP-2 inhibitor
GC17738 MMP-2 Inhibitor I
Matrix Metalloproteinase-2 Inhibitor I,cis-9-Octadecenoyl-N-hydroxylamide,Oleylhydroxamate
A selective MMP-2 inhibitor
GC11038 MMP-2/MMP-9 Inhibitor I
胶原酶,Metalloproteinase-2/Metalloproteinase-9 Inhibitor I
An inhibitor of MMP-2 and MMP-9
GC10149 cis-ACCP A matrix metalloproteinase inhibitor
GC17245 MMP-13 Inhibitor
N4,N6-双(4-氟-3-甲基苄基)嘧啶-4,6-二甲酰胺,Collagenase-3 Inhibitor,Matrix Metalloproteinase-13 Inhibitor,4,6-Pyrimidinedicarboxamide
A selective MMP-13 inhibitor
GC11764 MMP Inhibitor II
Matrix Metalloproteinase Inhibitor II,NHDDPC,PG 117025,PGE 4410186
A broad-range inhibitor of MMPs
GC16350 Actinonin
放线酰胺素,(-)-Actinonin,Ro 06-1467
An aminopeptidase inhibitor
GC15726 NNGH
N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl Hydroxamic Acid,Matrix Metalloproteinase-3 Inhibitor II,MMP-3 Inhibitor II
A broad-spectrum MMP inhibitor