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Serine Protease(丝氨酸蛋白酶)

Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.

Products for  Serine Protease

  1. Cat.No. 产品名称 Information
  2. GC90894 Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)

    Sp-ADP-α-S

    ADP-α-S的同分异构体

  3. GC90893 Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)

    Rp-ADP-α-S

    ADP-α-S的同分异构体

  4. GC69422 M4K2234 M4K2234 (compound 26b) 是 ALK2 的抑制剂。M4K2234 抑制 ALK2 和 ALK5 的 IC50 值分别为 5 和 2144 nM。M4K2234 可用作 ALK1 和 ALK2 蛋白激酶的化学探针。M4K2234 可用于癌症的研究。
  5. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
  6. GC49221 QLT0267 An ILK inhibitor
  7. GC39256 LP-935509 LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM),一种 ATP 竞争性抑制剂,其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。
  8. GC32731 OSU-T315 (ILK-IN-1)

    OSU-T315 analog

    An ILK inhibitor
  9. GC15682 Chymostatin

    胰凝乳蛋白酶抑制剂

    A potent inhibitor of chymotrypsin and chymase
  10. GC13967 Tosyllysine Chloromethyl Ketone (hydrochloride)

    (3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐,1-Chloro-3-Toxylamide-7-Amino-L-2-Heptanone,TLCK

    A non-selective proteinase inhibitor
  11. GC13421 UCF 101 An Omi/HtrA2 protease inhibitor
  12. GC17711 PPACKII (trifluoroacetate salt)

    H-D-Phe-Phe-Arg-Chloromethyl Ketone

    An irreversible inhibitor of kallikreins
  13. GC10477 PMSF

    苯甲基磺酰氟; Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride

    PMSF (苯甲基磺酰氟)是一种不可逆的丝氨酸蛋白酶抑制剂,常在细胞或组织裂解之前加入裂解液中以预防蛋白的降解。
  14. GC10613 Nafamostat Mesylate(FUT-175)

    甲磺酸萘莫司他; FUT-175

    A serine protease inhibitor
  15. GC12900 Aprotinin

    抑肽酶

    抑肽酶是一种天然存在的丝氨酸蛋白酶抑制剂,可挽救生命并降低中风和因大量出血而重复手术的风险1, 2, 3。
  16. GC14502 AEBSF.HCl

    4-(2-氨乙基)苯磺酰氟盐酸盐,AEBSF.HCl,AEBSF Hydrochloride

    AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂,可抑制胰凝乳蛋白酶,激肽释放酶,纤溶酶,凝血酶,胰蛋白酶和相关的溶栓酶等。
  17. GC10027 Leupeptin, Microbial

    亮肽素

    Leupeptin, Microbial 是一种广谱丝氨酸和半胱氨酸蛋白酶抑制剂。

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