Serine Protease(丝氨酸蛋白酶)
Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.
Products for Serine Protease
- Cat.No. 产品名称 Information
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GC90894
Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
Sp-ADP-α-S
ADP-α-S的同分异构体
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GC90893
Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
Rp-ADP-α-S
ADP-α-S的同分异构体
- GC69422 M4K2234 M4K2234 (compound 26b) 是 ALK2 的抑制剂。M4K2234 抑制 ALK2 和 ALK5 的 IC50 值分别为 5 和 2144 nM。M4K2234 可用作 ALK1 和 ALK2 蛋白激酶的化学探针。M4K2234 可用于癌症的研究。
- GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
- GC49221 QLT0267 An ILK inhibitor
- GC39256 LP-935509 LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM),一种 ATP 竞争性抑制剂,其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。
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GC32731
OSU-T315 (ILK-IN-1)
OSU-T315 analog
An ILK inhibitor -
GC15682
Chymostatin
胰凝乳蛋白酶抑制剂
A potent inhibitor of chymotrypsin and chymase -
GC13967
Tosyllysine Chloromethyl Ketone (hydrochloride)
(3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐,1-Chloro-3-Toxylamide-7-Amino-L-2-Heptanone,TLCK
A non-selective proteinase inhibitor - GC13421 UCF 101 An Omi/HtrA2 protease inhibitor
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GC17711
PPACKII (trifluoroacetate salt)
H-D-Phe-Phe-Arg-Chloromethyl Ketone
An irreversible inhibitor of kallikreins -
GC10477
PMSF
苯甲基磺酰氟; Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
PMSF (苯甲基磺酰氟)是一种不可逆的丝氨酸蛋白酶抑制剂,常在细胞或组织裂解之前加入裂解液中以预防蛋白的降解。 -
GC10613
Nafamostat Mesylate(FUT-175)
甲磺酸萘莫司他; FUT-175
A serine protease inhibitor -
GC12900
Aprotinin
抑肽酶
抑肽酶是一种天然存在的丝氨酸蛋白酶抑制剂,可挽救生命并降低中风和因大量出血而重复手术的风险1, 2, 3。 -
GC14502
AEBSF.HCl
4-(2-氨乙基)苯磺酰氟盐酸盐,AEBSF.HCl,AEBSF Hydrochloride
AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂,可抑制胰凝乳蛋白酶,激肽释放酶,纤溶酶,凝血酶,胰蛋白酶和相关的溶栓酶等。 -
GC10027
Leupeptin, Microbial
亮肽素
Leupeptin, Microbial 是一种广谱丝氨酸和半胱氨酸蛋白酶抑制剂。