Tryptophan Hydroxylase(色氨酸羟化酶)
Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology.
Products for Tryptophan Hydroxylase
- Cat.No. 产品名称 Information
- GC73721 TPT-004 TPT-004是一种TPH抑制剂。
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GC63842
Rodatristat
KAR5417
Rodatristat (KAR5417) 是一种有效的 tryptophan hydroxylase 1 (TPH1) 和 TPH2 抑制剂,其 IC50 值分别为 33 nM 和 7 nM,并显著降低小鼠肠道中的血清素 (5-HT) 水平。 -
GC62458
Rodatristat ethyl
KAR5585
Rodatristat ethyl (KAR5585) 是一种首创的,具有口服活性的 tryptophan hydroxylase 1 (TPH1) 抑制剂,具有体外纳摩尔浓度,可降低 5-hydroxytryptamine (5-HT) 的水平并显着降低肺动脉高压 (PAH),
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GC61463
p-Ethynylphenylalanine
4-乙炔基-L-苯丙氨酸HCL,4-Ethynyl-L-phenylalanine
p-Ethynylphenylalanine(4-Ethynyl-L-phenylalanine)是一种高效、选择性的,可逆、竞争性的色氨酸羟化酶(TPH)抑制剂,其Ki值为32.6μM。 -
GC60516
4-Ethynyl-L-phenylalanine hydrochloride
4-Ethynyl-L-phenylalanine hydrochloride
4-Ethynyl-L-phenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种有效的、选择性的、可逆的和竞争性的色氨酸羟化酶 (TPH) 抑制剂,Ki 为 32.6 μM. -
GC37755
LX1606 (Telotristat ethyl)
特罗司他乙酯,LX1032; LX1606
LX1606 (Telotristat ethyl) (LX1032) 是一种新型的口服色氨酸羟化酶抑制剂,可减少血清素的产生。 -
GC44083
LP-533401
L-苯丙氨酸,4[2-AMINO-6-(3-[2,2,2-三氟-1-氟[1,1'-联苯-4-乙氧基])]-4-PYRIMIDINYL]—
An inhibitor of gut-derived serotonin biosynthesis - GC13293 LP533401 hcl An inhibitor of gut-derived serotonin biosynthesis
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GC14064
p-Chlorophenylalanine
芬克洛宁; 4-Chloro-DL-phenylalanine; PCPA; CP-10188; DL-4-Chlorophenylalanine; 对氯苯丙氨酸
An inhibitor of tryptophan hydroxylase -
GC16279
Telotristat
LP778902
A TPH1 inhibitor -
GC10007
LX1606 Hippurate (Telotristat etiprate)
特罗司他马尿酸盐; LX1606 Hippurate
Telotristat etiprate 是一种乙酯前药,可在体内和体外水解为其活性部分 LP-778902。 -
GC15998
LX-1031
4-[2-氨基-6-[(1R)-2,2,2-三氟-1-(3'-甲氧基联苯-4-基)乙氧基]嘧啶-4-基]-L-苯丙氨酸,LX1031; LX 1031
LX-1031 是一种有效的、可口服的色氨酸 5-羟化酶 (TPH) 抑制剂,可减少外周血清素 (5-HT) 的合成。