Other Signal Transduction(其他信号转导)

Signal Transduction

Cellular responses are triggered by proteins, drugs, or pathogens binding to specific receptors. Receptor mediated signaling is a cascade of enzymatic reactions that amplifies the signal. The agonists and antagonists modulating receptor functionality are essential tools for research and medical practice. read more

Products for Other Signal Transduction

Cat.No. 产品名称 Information
GC91849 Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
GC91790 AMG PERK 44 (hydrochloride) AMG PERK 44 is a protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 6 nM).
GC91140 BMS 502
一种DGK-α、DGK-ζ和DGK-ι的抑制剂。
GC91040 AP-1
一种促进ALK降解的PROTAC
GC90894 Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
Sp-ADP-α-S

ADP-α-S的同分异构体
GC90893 Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
Rp-ADP-α-S

ADP-α-S的同分异构体
GC90886 SZM-1209
一种RIPK1抑制剂
GC90529 Myelin Basic Protein Peptide (mouse, bovine) (trifluoroacetate salt)
Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu, MBP Peptide

一种PKC的肽底物
GC25450 GATA4-NKX2-5-IN-1
3i-1000

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM
GC52362 ENPP3 Inhibitor 4g An ENPP1 and ENPP3 inhibitor
GC52361 AMARA Peptide (trifluoroacetate salt)
AMARAASAAALARRR-OH, H-Ala-Met-Ala-Arg-Ala-Ala-Ser-Ala-Ala-Ala-Leu-Ala-Arg-Arg-Arg-OH
A peptide substrate for AMPK
GC52336 ENPP1 Inhibitor 43 An ENPP1 inhibitor
GC52328 KYL (trifluoroacetate salt)
KYL Peptide
An EphA4 inhibitor
GC52322 ENPP3 Inhibitor 4t An ENPP3 inhibitor
GC52277 ENPP3 Inhibitor An ENPP3 inhibitor
GC52274 Y-33075 (hydrochloride)
RKI-983, SNJ-1656, Y-39983
An inhibitor of ROCK2
GC52151 PKCθ Inhibitor (hydrochloride)
Protein Kinase C θ Inhibitor
A PKCθ inhibitor
GC52141 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide
2-氯-N-甲基-N-(4-硝基苯基)乙酰胺
A synthetic intermediate
GC52129 3-Amino-5-hydroxybenzoic Acid
3-氨基-5-羟基苯甲酸
A biosynthetic precursor to ansamycin antibiotics
GC52115 S-99 An inhibitor of ASK1
GC52002 Emavusertib
CA-4948
An IRAK4 inhibitor
GC49912 13C20,15N10-Cyclic di-GMP (sodium salt)
13C20,15N10-c-di-GMP, 13C20,15N10-Cyclic diguanylate, 13C20,15N10-3’,5’-Cyclic diguanylic Acid
An internal standard for the quantification of cyclic di-GMP
GC49890 β-Glycerophosphate-d5 (sodium salt hydrate)
Glycerol 2-Phosphate-d5
An internal standard for the quantification of β-glycerophosphate
GC49789 Dihydronarwedine
二氢加兰他敏盐酸盐
An alkaloid and GSK3β inhibitor
GC49692 Tofacitinib-d3 (citrate)
Tasocitinib-d3 citrate; CP-690550-d3 citrate
An internal standard for the quantification of tofacitinib
GC49556 Cl-Necrostatin-1
7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f
A RIPK1 inhibitor
GC49494 4-Aminobenzylphosphonic Acid
4-氨基苄基膦酸
An alkaline phosphatase inhibitor
GC49433 Capsiate
辣椒素酯
A capsaicin analog with diverse biological activities
GC49403 Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone
GC49392 CHIR98024
CT 98024
A GSK3 inhibitor
GC49334 Chroman 1 (hydrochloride hydrate)
(S)-Chroman 1
A ROCK2 inhibitor
GC49332 Calcineurin Substrate (trifluoroacetate salt)
H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH, H-DLDVPIPGRFDRRVSVAAE-OH
A synthetic peptide substrate
GC49300 BIM-46187 (hydrochloride) An inhibitor of heterotrimeric G-protein signaling
GC49284 GSK-A1 A PI4KIIIα inhibitor
GC49269 Myr-ZIP
Myristoylated-ZIP, Myristoylated Zeta-Pseudosubstrate Inhibitory Peptide, Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu, Myr-SIYRRGARRWRKL-OH, Ζeta Inhibitory Peptide
A PKMζ inhibitor
GC49265 PKI (14-22) amide (myristoylated) (trifluoroacetate salt)
Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2, Myr-GRTGRRNAI-NH2, Myristoylated PKI-(14-22)-amide, PKI-(Myr-14-22)-amide
A PKA inhibitor
GC49221 QLT0267 An ILK inhibitor
GC49150 Tpl2 Kinase Inhibitor (hydrochloride)
c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor
A Tpl2 inhibitor
GC49110 AICA Ribonucleotide
5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐
An AMPK activator
GC49090 Nilvadipine-d4
(±)-Nilvadipine-d4
An internal standard for the quantification of nilvadipine
GC49079 C82 An Mtb CdnP inhibitor
GC49074 Forphenicine A bacterial metabolite and an inhibitor of alkaline phosphatase
GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases
GC19775 M2N12 M2N12 是一种有效且高度选择性的细胞分裂周期 25C 蛋白磷酸酶 (Cdc25C) 抑制剂，IC50 值为 0.09 μM。 M2N12 对 Cdc25A 和 Cdc25B 也有很好的活性，IC50 值分别为 0.53 μM 和 1.39 μM。 M2N12具有抗肿瘤活性，可用于癌症研究。
GC48120 T-2 Toxin-13C24
Fusariotoxin T-2-13C24, Insariotoxin-13C24, Mycotoxin T-2-13C24
A neuropeptide with diverse biological activities
GC48090 Sphingosine-d9 (d18:1)
D-erythro-Sphingosine C18-d9
A neuropeptide with diverse biological activities
GC48089 Sphingosine-13C2-d2 (d18:1)
D-erythro-Sphingosine C18-13C2-d2
A neuropeptide with diverse biological activities
GC39256 LP-935509 LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM)，一种 ATP 竞争性抑制剂，其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。
GC45894 Daunorubicin-13C-d3 A neuropeptide with diverse biological activities
GC45304 1,3-Dipalmitoyl-rac-glycerol
1,3-双棕榈酸甘油酯
A diacylglycerol