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Home >> Signaling Pathways >> Stem Cell

Stem Cell(干细胞)

  1. Cat.No. 产品名称 Information
  2. GC62424 PY-60 PY-60 是一种靶向膜联蛋白A2 (ANXA2) 的 YAP 转录活性的特异的激活剂 (Kd=1.4 µM)。PY-60 直接与 ANXA2 结合并拮抗其抑制 YAP 活性的正常细胞功能。
  3. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1，一种咪唑衍生物，是 cdk5，cdk2 和 GSK-3 的抑制剂。GSK-3/CDK5/CDK2-IN-1 可用于癌症和神经退行性疾病的研究。详细信息请参考专利文献 WO2002010141A1 中的化合物 9a。
  4. GC62394 Teplinovivint Teplinovivint 是一种有效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性，具有用于肌腱病研究的潜力。
  5. GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 是一种有效，选择性，不可逆和共价的糖原合酶激酶 3β (GSK-3β) 抑制剂，IC50 值为 6.6 μM。GSK-3β inhibitor 3 可用于急性早幼粒细胞白血病的研究。
  6. GC62337 CK2 inhibitor 2 CK2 inhibitor 2 是一种有效的，选择性和具有口服活性的 CK2 抑制剂，IC50 值为 0.66 nM。CK2 inhibitor 2 对 Clk2 (IC50=32.69 nM)/CK2 显示出高选择性。 CK2 inhibitor 2 具有良好的抗增殖和抗肿瘤活性。
  7. GC62258 SAG-d3 SAG-d3 是 SAG 的氘代物。SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。
  8. GC62214 FIDAS-3 FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.
  9. GC62132 K-975 K-975 is a potent, selective and orally active TEAD inhibitor that directly inhibits YAP/TAZ-TEAD protein-protein interaction and shows a potent anti-tumor effect in malignant pleural mesothelioma.
  10. GC61925 hSMG-1 inhibitor 11j

    嘧啶杂质1

     hSMG-1 inhibitor 11j，一种嘧啶衍生物，是有效的和选择性的 hSMG-1 抑制剂，IC50 值为 0.11 nM。hSMG-1 inhibitor 11j 对 hSMG-1 的选择性是 mTOR (IC50=50 nM)，PI3Kα/γ (IC50=92/60 nM) 和 CDK1/CDK2 (IC50=32/7.1 µM) 的 455 倍以上。hSMG-1 inhibitor 11j 可用于癌症研究。
  11. GC61861 Oct3/4-inducer-1 An inducer of Oct3/4 expression
  12. GC61781 Super-TDU Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
  13. GC61527 Lats-IN-1

    Lats-IN-1

     An inhibitor of LATS1 and LATS2
  14. GC61410 I3MT-3

    HMPSNE

     I3MT-3 (HMPSNE, compound 3) is a potent, selective, and cell-membrane permeable inhibitor of 3-mercaptopyruvate sulfurtransferase (3MST) with IC50 of 2.7 μM. I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST.
  15. GC48434 Elsinochrome A

    痂囊腔菌素AELSINOCHROMEA

     A fungal metabolite
  16. GC50703 Yhhu 3792 Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo
  17. GC50685 Dynapyrazole A Dynein inhibitor
  18. GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7
  19. GC48062 RU-SKI 201 (hydrochloride) A neuropeptide with diverse biological activities
  20. GC47570 Lipoxygenin An inhibitor of 5-LO
  21. GC47538 L-Ascorbic Acid 2-phosphate (magnesium salt hydrate)

    2-Phospho-L-ascorbic acid magnesium hydrate

     A long-acting ascorbic acid derivative
  22. GC47474 Itraconazole-d5

    R51211-d5

     An internal standard for the quantification of itraconazole
  23. GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
  24. GC47372 Foxy-5 (trifluoroacetate salt)

    N-formyl-Met-Asp-Gly-Cys-Glu-Leu, N-formyl-MDGCEL

     A neuropeptide with diverse biological activities
  25. GC47095 cis-Vaccenic Acid-d13

    18:1 cis-11-d13, cis-11-Octadecenoic Acid-d13

     cis-Vaccenic acid-d13 是氘标记的cis-Vaccenic 酸。 cis-Vaccenic acid 是红假单胞菌荚膜的抗病毒提取物，也是红假单胞菌荚膜的主要活性成分，可作为潜在的胎儿血红蛋白诱导剂。
  26. GC46986 C18 Ceramide-1-phosphate-d3 (d18:1/18:0-d3)

    Ceramide-1-phosphate (d18:1/18:0-d3), CerP(d18:1/18:0-d3), N-octadecanoyl-D-erythro-Sphingosine-1-phosphate-d3

     A neuropeptide with diverse biological activities
  27. GC46947 BRD-K4477

    NSC 12407; BRD-K4477

     A small molecule promotor of hepatocyte differentiation
  28. GC46939 BODIPY-aminoacetaldehyde diethyl acetal

    BAAA-DA

     BODIPY-aminoacetaldehyde diethyl acetal（BAAA-DA）是BODIPY-氨基乙醛（BAAA）的稳定前体，BAAA是醛脱氢酶（ALDH）的细胞渗透性荧光底物，Ex/Em为488/512nm。
  29. GC61233 RBPJ Inhibitor-1

    RIN1

     RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
  30. GC61093 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
  31. GC60970 KY19382

    A3051

     KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.
  32. GC60348 Supinoxin

    RX-5902

     Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶 (P-p68) 的强效口服活性抑制剂，并且是一个一流的抗肿瘤试剂 (anti-cancer agent)。Supinoxin 与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。 Supinoxin 诱导细胞凋亡 (apoptosis) 并抑制 TNBC 癌细胞系的生长，IC50 的范围为 10 nM 至 20 nM。
  33. GC60037 A-3 hydrochloride

    赤霉酸

     A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  34. GC18533 ZLDI-8 ZLDI-8 是一种 Notch 激活/切割酶 ADAM-17 抑制剂，可抑制 Notch 蛋白的切割。 ZLDI-8 降低促存活/抗凋亡和上皮间质转化 (EMT) 相关蛋白的表达。 ZLDI-8 还是一种竞争性且不可逆的酪氨酸磷酸酶 (Lyp) 抑制剂，IC50 为 31.6 μM，Ki 为 26.22 μM。 ZLDI-8 抑制 MHCC97-H 细胞的生长，IC50 为 5.32 μM。
  35. GC39508 SNDX-5613

    SNDX-5613

     SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
  36. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8
  37. GC39461 YAP-TEAD-IN-1 TFA YAP-TEAD TFA 是 YAP-TEAD 相互作用的有效的竞争性肽类抑制剂 (IC50=25 nM)。YAP-TEAD TFA 是一种 17mer 的多肽，与 YAP (50-171) (Kd=40 nM) 相比，其与 TEAD1 的结合亲和力更高 (Kd= 15 nM)。
  38. GC39359 Ciliobrevin D Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.
  39. GC50624 FzM1.8 FzM1.8 源自 FzM1，是 FZD4 的变构激动剂，pEC50 为 6.4。 FzM1.8 通过在没有任何 WNT 配体的情况下促进 TCF/LEF 转录活性，与 FZD4 结合并激活 WNT/β-连环蛋白途径。 FzM1.8 结合稳定 FZD4，增加对异源三聚体 G 蛋白的亲和力，并刺激 Gβγ 亚基的释放，进而激活 PI3K。
  40. GC50489 NLS-StAx-h NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂，IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。
  41. GC50486 Dynarrestin A dynein inhibitor
  42. GC50470 SAHM1 SAHM1 是一种类似于主脑样 (MAML) 的显性阴性形式的肽模拟物，可抑制典型的 Notch 转录复合物形成。
  43. GC50323 AMBMP hydrochloride AMBMP hydrochloride 是一种有效的细胞渗透性 Wnt 信号激活剂。 BML-284 诱导 TCF 依赖性转录活性，EC50 为 700 nM。
  44. GC50203 IHR-Cy3 IHR-Cy3 是一种有效的荧光 Smo 拮抗剂，IC50 为 100 nM。
  45. GC50135 SAG 21k Hedgehog signaling activator; brain penetrant and orally bioavailable
  46. GC50077 WAY 316606 hydrochloride An sFRP-1 inhibitor
  47. GC39266 Hematein

    氧化苏木精

     Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.
  48. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
  49. GC39159 Tegatrabetan

    BC2059

     Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
  50. GC39152 9-ING-41

    Elraglusib

     A GSK3β inhibitor
  51. GC38892 BIP-135 BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC50 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。

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