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Home >> Signaling Pathways >> Stem Cell

Stem Cell(干细胞)

  1. Cat.No. 产品名称 Information
  2. GC43847 Histone H3K27Me2 (21-44)-GK-biotin (trifluoroacetate salt)

    ATKAAR-K(Me2)-SAPATGGVKKPHRYRPG-GK(Biotin), Histone H3 (21-24) (Lys27me2)-GK(Biotin), Lys(Me2)27-Histone H3 (21-44)-GK(Biotin) (trifluoroacetate salt)

     A biotinylated peptide fragment of histone H3
  3. GC43809 Hedgehog Antagonist VIII

    Hh Antagonist VIII

     An inhibitor of hedgehog pathway signaling
  4. GC43734 Ganglioside GQ1b Mixture (sodium salt)

    神经节苷脂GQ1B四钠盐

    A mixture of ganglioside GQ1b
  5. GC43729 Ganglioside GD3 Mixture (sodium salt)

    双唾液酸神经节苷脂GD3; Disialosyllactosylceramide

     A mixture of ganglioside GD3
  6. GC43725 Gallocyanine

    花菁

     A Dkk1 inhibitor
  7. GC43618 Epiblastin A An inhibitor of CK1α, CK1δ, and CK1ε
  8. GC43462 Dihydrolipoic Acid

    (+/-)-二氢硫辛酸,DHLA

     A reduced form of α-lipoic acid
  9. GC43346 Cyclopamine-KAAD

    3-酮-N-氨基乙基-N'-氨基己酰二氢肉桂酰环杷明,Cyclopamine-KAAD

     A potent inhibitor of hedgehog signaling
  10. GC42944 BIX01294 (hydrochloride hydrate) An inhibitor of G9a histone methyltransferase
  11. GC42669 ABC99 An inhibitor of NOTUM
  12. GC41719 (R)-nitro-Blebbistatin

    R(-)7Desmethyl8nitro Blebbistatin

     A more stable form of (+)-blebbistatin
  13. GC41587 cis-Vaccenic Acid

    顺-十八碳烯酸

     An ω-7 fatty acid
  14. GC41534 FzM1

    Frizzled M1

     An allosteric ligand of Frizzled4
  15. GC41468 Retreversine An inactive isomer of reversine
  16. GC40571 24(S),25-epoxy Cholesterol

    (24S)-24,25-环氧胆固醇,24(S)-24,25-EC

     An oxysterol
  17. GC34818 Super-TDU 1-31 Super-TDU(1-31)是Super-TDU的多肽片段。Super-TDU为YAP-TEADs相互作用抑制剂，具有抗肿瘤活性。
  18. GC34650 Longdaysin

    Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.
  19. GC34635 JI051 JI051是一种Hes1-PHB2相互作用稳定剂，能够与癌症相关蛋白伴侣prohibitin2(PHB2)相互作用，通过抑制Notch下游效应基因Hes1来诱导细胞周期停滞。具有抗肿瘤作用。
  20. GC34628 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
  21. GC34536 CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.
  22. GC34463 ALLO-2 ALLO-2 is potent antagonist of both wild-type mouse Smo and drug-resistant D473H mutant human Smo that inhibits Smo agonist inhibited Gli-Luc activity in TM3-Gli-Luc cells with IC50 of 6 nM.
  23. GC34356 Casein Kinase II Inhibitor IV Hydrochloride CaseinKinaseIIInhibitorIVHydrochloride是表皮角质形成细胞分化的小分子诱导剂。
  24. GC33304 Gigantol

    大叶兰酚

     Gigantol是一种来自几种药用兰花的联苄基化合物。Gigantol对癌症有潜在治疗价值。Gigantol是Wnt/β-catenin通路的抑制剂。
  25. GC33114 MRT-83 MRT-83是有效的Smo拮抗剂，其IC50值在纳摩尔级别。
  26. GC32978 Saridegib (IPI-926)

    IPI-926; Patidegib

     Saridegib (IPI-926) 是一种有效且特异性的 Smoothened (Smo) 抑制剂，Smoothened (Smo) 是 Hedgehog (Hh) 通路中的关键信号跨膜蛋白。
  27. GC32954 LEQ506 (NVP-LEQ506)

    NVP-LEQ506

     LEQ506 (NVP-LEQ506) 是第二代平滑 (Smo) 抑制剂，在人和小鼠中的 IC50 分别为 2 和 4 nM。
  28. GC32923 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
  29. GC32914 EMT inhibitor-1 EMTinhibitor-1是Hippo，TGF-β和Wnt信号通路的抑制剂，并拥有抗肿瘤活性。
  30. GC32877 GNF-6231 GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
  31. GC32763 LF3 An inhibitor of the β-catenin-TCF4 protein-protein interaction
  32. GC32698 Pyrvinium pamoate (Pyrvinium embonate)

    扑蛲灵,Pyrvinium embonate

     An anthelmintic and anticancer agent
  33. GC31794 Methyl vanillate

    香草酸甲酯

    Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
  34. GC31717 Ginkgetin

    银杏双黄酮

     A biflavonoid with diverse biological activities
  35. GC31663 Adavivint (SM04690)

    SM04690; Lorecivivint

     Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ?150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
  36. GC31268 tCFA15 tCFA15为一种三甲基环己烯长链脂肪醇，侧链含有15个碳原子，能够促进神经细胞的分化，具有调控Notch信号通路的潜力。
  37. GC30767 Heparan Sulfate

    硫酸乙酰肝素

     硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。
  38. GC30276 Casein Kinase II Inhibitor IV

    CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。
  39. GC19336 SR-3029 An inhibitor of CK1δ and CK1ε
  40. GC19299 Porcupine-IN-1

    PORCN-IN-1

     An inhibitor of Wnt and hedgehog signaling
  41. GC19260 NCB-0846

    顺式-4-((2-((1H-苯并[D]咪唑-6-基)氨基)喹唑啉-8-基)氧基)环己醇

     A TNIK inhibitor
  42. GC19216 KYA1797K An inhibitor of Wnt/β-catenin signaling
  43. GC19198 iCRT3 iCRT3 是 Wnt 和 β-连环蛋白反应性转录的抑制剂。
  44. GC19144 ETC-159

    1,2,3,6-四氢-1,3-二甲基-2,6-二氧代-N-(6-苯基-3-哒嗪基)-7H-嘌呤-7-乙酰胺,ETC-1922159

     A potent, orally bioavailable inhibitor of PORCN
  45. GC18875 GSK3β Inhibitor XVIII An inhibitor of GSK3β
  46. GC18734 JS-K A nitric oxide donor
  47. GC18616 MMP-8 Inhibitor I

    Matrix Metalloproteinase-8 Inhibitor I

     A selective inhibitor of MMP-8
  48. GC18599 PF-05274857 (hydrochloride) PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂，IC50 为 5.8 nM，Ki 为 4.6 nM。 PF-05274857（盐酸盐）具有研究肿瘤类型的潜力，包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
  49. GC18595 G244-LM An inhibitor of Wnt signaling
  50. GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
  51. GC18291 PKF118-310

    毒黄素,Xanthothricin; Toxoflavine; PKF-118-310

     An inhibitor of the Tcf4-β-catenin protein interaction

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