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Home >> Signaling Pathways >> Stem Cell

Stem Cell(干细胞)

  1. Cat.No. 产品名称 Information
  2. GC11045 HPI 1 A Hedgehog pathway inhibitor
  3. GC11193 SANT-2

    N-[3-(1H-苯并咪唑-2-基)-4-氯苯基]-3,4,5-三乙氧基苯甲酰胺

     A Smoothened receptor antagonist
  4. GC15256 JK 184

    N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺

     An inhibitor of downstream hedgehog signaling
  5. GC15683 LY2940680

    4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺,LY2940680

     A Smo antagonist
  6. GC11548 Tankyrase Inhibitors (TNKS) 49

    TNKS 49;TNKS49;TNKS-49

     Tankyrase inhibitor
  7. GC15041 Tankyrase Inhibitors (TNKS) 22

    TNKS 22;TNKS22;TNKS-22

     Tankyrase inhibitor
  8. GC17153 CHIR-99021 (CT99021) HCl

    CHIR-99021 monohydrochloride; CT99021 monohydrochloride

     A selective GSK3 inhibitor
  9. GC12176 CHIR-98014 A reversible, cell-permeable inhibitor of GSK3
  10. GC13280 PF-5274857 PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂，IC50 为 5.8 nM，Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力，包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
  11. GC13441 Cyclopamine

    环巴胺; 11-Deoxojervine

     Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。
  12. GC13037 CX-4945 (Silmitasertib)

    CX 4945;CX4945

     A potent, orally bioavailable CK2 inhibitor
  13. GC14482 Verteporfin

    维替泊芬; CL 318952

     维替泊芬是一种有效的 PD-L1 表达抑制剂，用于治疗年龄相关性黄斑变性、鲜红斑痣和癌症。
  14. GC10359 GANT61

    2,2'-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺],NSC 136476

     GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。
  15. GC12781 XAV-939

    3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-D]嘧啶-4-酮

     XAV-939 选择性抑制 β-连环蛋白介导的转录。
  16. GC15548 Ellagic acid

    鞣花酸

     Polyphenolic antioxidant
  17. GC13028 SB 415286

    3-[(3-氯-4-羟苯基)氨基]-4-(2-硝苯基)-1H-吡咯-2,5-二酮

     A selective inhibitor of GSK-3
  18. GC10463 SB 216763 SB 216763是一种强效、选择性且ATP竞争性的GSK-3抑制剂，显著作用于GSK-3α和GSK-3β，其IC50仅为34.3 nM。
  19. GC15064 Purmorphamine

    嘌呤胺

     Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。
  20. GC17043 StemRegenin 1 (SR1)

    SR1

     Antagonizes hematopoietic stem cell differentiation
  21. GC16893 ICG 001 ICG001 是一种靶向 Wnt/β-catenin 通路的小分子抑制剂。
  22. GC14572 KY 02111 Induces stem cell differentiation
  23. GC11674 WIKI4

    Tankyrase 1/2 Inhibitor V

     A potent TNKS1/2 inhibitor
  24. GC12869 JW 55

    Tankyrase 1/2 Inhibitor IV

     A TNKS1/2 inhibitor
  25. GC16584 TCS 21311

    NIBR3049

     A JAK3 inhibitor
  26. GC10649 TTP 22

    TTP22;TTP-22

     A CK2 inhibitor
  27. GC14037 Triptonide

    雷公藤内酯酮; NSC 165677; PG 492

     A diterpenoid with diverse biological activities
  28. GC12181 TBB

    4,5,6,7-四溴-1H-苯并三唑,NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo-

     An inhibitor of CK2
  29. GC18107 Salinomycin sodium salt

    盐霉素钠; Salinomycin sodium; Sodium salinomycin

     A selective cancer stem cell inhibitor
  30. GC14882 Salinomycin

    盐霉素; Procoxacin

     A selective cancer stem cell inhibitor
  31. GC10556 PF-670462

    4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐,PF 670462;PF670462

     An inhibitor of the CK1 isoforms CK1ε and CK1δ
  32. GC17187 LY2090314

    LY 2090314;LY-2090314

     A potent and selective inhibitor of GSK3
  33. GC14169 LDE225 Diphosphate

    LDE 225 Diphosphate;NVP-LDE 225 Diphosphate;Erismodegib Diphosphate;LDE-225 Diphosphate

     A Smo antagonist
  34. GC16454 IWP-2

    IWP 2

     IWP-2 是Wnt信号通路中Porcupine 酶的特异性抑制剂,IC50值为 27 nM。
  35. GC12951 HhAntag

    N-[4-氯-3-[5-(二甲基氨基)-1H-苯并咪唑-2-基]苯基]-3,5-二甲氧基苯甲酰胺

     A hedgehog pathway inhibitor
  36. GC17534 GSK343

    GSK-343;GSK 343

     A selective, cell-permeable EZH2 inhibitor
  37. GC15783 GSK126

    EZH2 inhibitor;GSK-126;GSK 126

     GSK126(GSK2816126A, GSK2816126)是一种高选择性EZH2甲基转移酶抑制剂，在体外的IC50为12.6~17.4nM；在体内的IC50为9.9nM。
  38. GC16789 GANT 58

    4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine,NSC 75503;GANT58;GANT-58;NSC-75503

     An inhibitor of Gli transcription
  39. GC12134 FH535

    2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺,FH 535;FH-535

     An inhibitor of β-catenin signaling
  40. GC16044 Emodin

    大黄素; Frangula emodin

     Natural CK2 inhibitor and ER agonist
  41. GC17837 DMAT

    2-二甲基氨基-4,5,6,7-四溴苯并咪唑,Casein kinase II Inhibitor;CK2 Inhibitor

     A cell-permeable inhibitor of CK2
  42. GC13202 D4476

    4-[4-(2,3-二氢-1,4-苯并二氧杂环己-6-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺,Casein Kinase I Inhibitor;D 4476;D-4476

     Inhibitor of CK1 and ALK5
  43. GC13628 BMS-833923

    BMS 833923;BMS833923;XL-139;XL139;XL 139

     An orally bioavailable Smo inhibitor
  44. GC15425 AR-A014418

    AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor

     A selective inhibitor of GSK3β
  45. GC17107 PluriSIn #1 (NSC 14613)

    NSC 14613

     A selective inhibitor of stearoyl-CoA desaturase
  46. GC12653 LY3039478

    LY3039478

     A Notch inhibitor
  47. GC15794 Valproic acid sodium salt (Sodium valproate)

    丙戊酸钠; Sodium Valproate sodium

     Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶 （HDAC）抑制剂，IC50 值为1.5mM，抑制HDAC1的IC50值为400μM，同时可诱导HDAC2的降解。
  48. GC13878 EPZ005687

    EPZ 005687,EPZ-005687

     A potent, selective inhibitor of EZH2
  49. GC13673 BMS-708163 (Avagacestat)

    BMS-708163

     A potent inhibitor of γ-secretase
  50. GC12191 LY-411575

    (AS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-ALPHA-羟基苯乙酰胺

     A γ-secretase inhibitor
  51. GC17671 YO-01027 (Dibenzazepine, DBZ)

    二苯并氮卓,gamma-Secretase Inhibitor XX,YO01027

     An inhibitor of γ-secretase

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