Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Products for Hedgehog

Cat.No. 产品名称 Information
GC74091 Itraconazole-d9
R51211-d9
Itraconazole-d9是氘标记的伊曲康唑。
GC73776 DS-1-38 DS-1-38是一种EYA1拮抗剂，可阻断Sonic Hedgehog （SHH）信号。
GC73310 SMO-IN-2 SMO-IN-2（化合物1）是一种有效的SMO （smoothened）抑制剂，对hedgehog （Hh）信号通路的IC50值为123.4 nM。
GC72838 1-Methyladenosine-d3 hydrochloride 1-Methyladenosine-d3 hydrochloride是氘的氯盐形式，标记为1-甲基腺苷。
GC91424 S1PL-IN-31
Sphingosine-1-Phosphate Lyase Inhibitor 31; S1PL Inhibitor 31; S1P Lyase Inhibitor 31
S1PL-IN-31是一种抑制神经酰胺-1-磷酸（S1P）裂解酶的抑制剂（IC50 = 210 nM）。它也是平滑蛋白受体（Smo）的拮抗剂（IC50 = 440 nM）。
GC66390 3-epi-Vitamin D3
Epicholecalciferol

3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4) 是维生素 D3 类似物，是一种 Hedgehog pathway 抑制剂，在U87MG 细胞中测定的 IC50 为 39.2 μM。
GC64134 Hh-Ag1.5
SAg1.5
Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂，EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。
GC49651 19-alkyne Cholesterol
19-ethynyl Cholesterol
An alkyne derivative of cholesterol for click chemistry
GC48062 RU-SKI 201 (hydrochloride) A neuropeptide with diverse biological activities
GC47570 Lipoxygenin An inhibitor of 5-LO
GC47474 Itraconazole-d5
R51211-d5
An internal standard for the quantification of itraconazole
GC47435 HPI-1 (hydrate) A Hedgehog pathway inhibitor
GC39359 Ciliobrevin D Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signaling.
GC37573 RU-SKI 43 An inhibitor of hedgehog acyltransferase
GC45090 Triparanol
曲帕拉醇,MER-29
An inhibitor of DHCR24
GC44855 RU-SKI 43 (hydrochloride)
RU-SKI 43（盐酸盐）
An inhibitor of hedgehog acyltransferase
GC44458 N-Palmitoyl-L-Aspartate
BRN 2295471
A natural N-acylaspartate
GC44321 Nat-20(S)-yne
Click Tag Nat-20(S)-yne
Nat-20(S)-OHC with a terminal alkyne group
GC43809 Hedgehog Antagonist VIII
Hh Antagonist VIII
An inhibitor of hedgehog pathway signaling
GC43346 Cyclopamine-KAAD
3-酮-N-氨基乙基-N'-氨基己酰二氢肉桂酰环杷明,Cyclopamine-KAAD
A potent inhibitor of hedgehog signaling
GC18475 Robotnikinin A direct inhibitor of sonic hedgehog
GC11217 CUR 61414
G-856
A potent inhibitor of hedgehog-induced activity
GC17713 Oxy-16
20(R),22(R)-dihydroxy Cholesterol
A synthetic oxysterol
GC13630 MK-4101
5-(3,3-二氟环丁基)-3-[4-[4-甲基-5-[2-(三氟甲基)苯基]-4H-1,2,4-三唑-3-基]双环[2.2.2]辛烷-1-基]-1,2,4-恶二唑
A Smoothened receptor antagonist
GC12068 SAG
Smoothened Agonist
SAG(Smoothened Agonist)是一种有效的Smo受体激动剂。
GC15422 20(S)-Hydroxycholesterol
20Α-羟基胆固醇,20α-hydroxy Cholesterol
An allosteric Smo agonist
GC15284 U 18666A U18666A是一种具有细胞渗透性和两亲性的小分子，可以抑制3β羟基甾醇-Δ（24）还原酶（DHCR24）活性, 从而阻止胆固醇从晚期核内体和溶酶体外流[2]。
GC15889 SANT-1 An antagonist of Smoothened
GC12429 AY 9944 dihydrochloride A cholesterol synthesis inhibitor
GC14715 AZ 12080282 dihydrochloride 刺猬抑制剂
GC11111 Jervine
蒜黎芦碱; 11-Ketocyclopamine
An inhibitor of the hedgehog signaling pathway
GC11476 Ciliobrevin A
HPI-4
A hedgehog pathway inhibitor
GC11045 HPI 1 A Hedgehog pathway inhibitor
GC11193 SANT-2
N-[3-(1H-苯并咪唑-2-基)-4-氯苯基]-3,4,5-三乙氧基苯甲酰胺
A Smoothened receptor antagonist
GC15256 JK 184
N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
An inhibitor of downstream hedgehog signaling
GC15683 LY2940680
4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺,LY2940680
A Smo antagonist
GC17153 CHIR-99021 (CT99021) HCl
CHIR-99021 monohydrochloride; CT99021 monohydrochloride
A selective GSK3 inhibitor
GC13280 PF-5274857 PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂，IC50 为 5.8 nM，Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力，包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
GC13441 Cyclopamine
环巴胺; 11-Deoxojervine
Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。
GC10359 GANT61
2,2'-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺],NSC 136476
GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。
GC15064 Purmorphamine
嘌呤胺
Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。
GC16789 GANT 58
4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine,NSC 75503;GANT58;GANT-58;NSC-75503
An inhibitor of Gli transcription
GC10493 GDC-0449 (Vismodegib)
维莫德吉; GDC-0449
GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂，IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2，IC50 值分别为 3.0 μM 和 1.4 μM。