TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for TGF-β / Smad Signaling

Cat.No. 产品名称 Information
GC32250 Chebulinic acid
诃子林鞣酸
An ellagitannin with diverse biological activities
GC31959 AS2521780 AS2521780是新颖的PKCθ选择性抑制剂，IC50值为0.48nM。
GC31952 ROCK-IN-1
ROCK-IN-1是一种有效的ROCK抑制剂，能够抑制ROCK2的活性，IC50值为1.2nM。
GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide))
常山酮溴酸盐; RU-19110 hydrobromide
Halofuginone (RU-19110) hydrobromid 是一种Ferifugine 衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂，Ki 为 18.3 nM。
GC31912 VTX-27 A PKCθ inhibitor
GC31892 Decursin ((+)-Decursin)
紫花前胡素; (+)-Decursin
A phytochemical with diverse biological activities
GC31883 ROCK2-IN-2 ROCK2-IN-2是一种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。
GC31711 PKC-IN-1
[(2S,5R)-2,5-二甲基-4-[(四氢-2H-吡喃-4-基)甲基]-1-哌嗪基][3-[(5-氟-2-甲基-4-嘧啶基)氨基]-4,6-二氢-6,6-二甲基吡咯并[3,4-C]吡唑-5(1H)-基]甲酮
PKC-IN-1是一种有效的，ATP-竞争性的，可逆的PKC抑制剂，对人PKCβ和PKCα的Ki值分别为5.3和10.4nM，对人PKCα，PKCβI，PKCβII，PKCθ，PKCγ，PKCmu和PKCε的IC50值分别为2.3，8.1，7.6，25.6，57.5，314，808nM。
GC31656 Ingenol Mebutate (Ingenol 3-angelate)
巨大戟醇甲基丁烯酸酯; Ingenol 3-angelate; PEP005
A natural cytotoxic diterpene ester
GC31650 Halofuginone (RU-19110)
常山酮; RU-19110
Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
GC30545 Malantide Malantide是一种十二肽，能够被PKA磷酸化，并且能够增强PKA的活性。
GC30200 PKC-theta inhibitor PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.
GC19447 SM 16 An inhibitor of ALK5
GC19338 SRI-011381 hydrochloride A TGF-β signaling activator
GC19234 LY3200882 An inhibitor of TGF-βRI
GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
GC19034 AR-13324 mesylate
奈他地尔二甲磺酸盐
AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞发生形态学变化。
GC18521 Cercosporin
尾孢菌素
A cytotoxic phytotoxin
GC18354 Bisindolylmaleimide X (hydrochloride)
BIM-X hydrochloride; Ro31-8425 hydrochloride
A PKC inhibitor
GC18246 R-59-949
Diacylglycerol Kinase Inhibitor II, DKGI-II
A DGK-α inhibitor
GC14134 1,2-Dimyristoyl-sn-glycerol
1,2-二肉豆蔻酸甘油酯,1,2-DMG
A long-chain DAG
GC18062 1,2-Dilauroyl-sn-glycerol
1,2-二月桂酰-SN-甘油,1,2-DLG
A long-chain DAG
GC12662 1,2-Distearoyl-sn-glycerol
1,2-Dioctadecanoyl-sn-glycerol,DSG
A diacylglycerol
GC16539 Butaprost
布他前列素
A selective agonist for the EP₂ receptors
GC10299 Hexadecyl Methyl Glycerol
1-O-hexadecyl-2-O-methyl-sn-Glycerol
A synthetic DAG
GC16678 UCN-02
7-epi-hydroxy Staurosporine
A PKC inhibitor
GC13877 1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol
GC17815 L-threo-Sphingosine C-18
L-threo-Sphingosine C-18
A D-erythro-sphingosine analog
GC13226 Bisindolylmaleimide VIII (acetate)
3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐,BIM VIII,Ro 31-7549
A PKC inhibitor
GC14716 Bisindolylmaleimide IV
双吲哚马来酰亚胺IV,Arcyriarubin A,BIM IV
A PKC inhibitor
GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator 是一种细胞可渗透的苯并内酰胺衍生蛋白激酶 C (PKC) 激活剂，Ki 为 11.9 nM。
GC11050 ALK5 Inhibitor II (hydrochloride)
E 616452,RepSox,SJN 2511
A selective inhibitor of ALK5
GC15018 Hispidin
6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮
A polyphenol with diverse biological activities
GC16405 Safingol
沙芬戈,L-threo-Dihydrosphingosine,L-threo-Sphinganine
A dual inhibitor of PKC and SPHK
GC11022 SB 218078 A potent Chk1 inhibitor
GC10716 Netarsudil (AR-13324)
2,4-二甲基苯甲酸[4-[(1S)-1-(氨基甲基)-2-(6-异喹啉基氨基)-2-氧代乙基]苯基]甲基酯二盐酸盐
ROCK抑制剂
GC17191 SIS3 HCl
SIS3 盐酸盐
SIS3 HCl是一种Smad3抑制剂，可抑制Smad3 的磷酸化， IC₅₀ 为3 μM。
GC13273 ZIP ZIP 是 PKMζ 的选择性肽抑制剂。
GC17239 Bisindolylmaleimide V
双吲哚马来酰亚胺,BIM V
A S6K inhibitor
GC10029 Ro 31-8220 methanesulfonate
Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate
Inhibitor of protein kinase C
GC10607 GNF-7 A multi-kinase inhibitor
GC17901 Tamoxifen
他莫昔芬; ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。
GC15884 Dasatinib Monohydrate
达沙替尼一水合物,BMS-354825 monohydrate
An inhibitor of Abl and Src
GC13354 EW-7197
Vactosertib，TEW-7197
A potent inhibitor of ALK5
GC12402 LX7101 HCL A LIMK and ROCK inhibitor
GC12108 ITD 1 An inhibitor of TGF-β
GC11140 Radotinib(IY-5511)
拉多替尼
A selective Bcr-Abl tyrosine kinase inhibitor
GC17242 (-)-epigallocatechin
(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
A green tea polyphenol
GC10603 (-)-epicatechin gallate
表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate
A natural polyphenol with diverse protective actions
GC12695 Bryostatin 3 Bryostatin 3 是一种大环内酯，是一种蛋白激酶 C 激活剂，Ki 为 2.75 nM。 Bryostatin 3 可以阻断 12-O-tetradecanoylphorbol-13-acetate (TPA) 对细胞增殖的抑制作用，但不能阻断 TPA 增强的细胞-基质粘附。