TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for TGF-β / Smad Signaling

Cat.No. 产品名称 Information
GC14134 1,2-Dimyristoyl-sn-glycerol
1,2-二肉豆蔻酸甘油酯,1,2-DMG
A long-chain DAG
GC18062 1,2-Dilauroyl-sn-glycerol
1,2-二月桂酰-SN-甘油,1,2-DLG
A long-chain DAG
GC12662 1,2-Distearoyl-sn-glycerol
1,2-Dioctadecanoyl-sn-glycerol,DSG
A diacylglycerol
GC16539 Butaprost
布他前列素
A selective agonist for the EP₂ receptors
GC10299 Hexadecyl Methyl Glycerol
1-O-hexadecyl-2-O-methyl-sn-Glycerol
A synthetic DAG
GC16678 UCN-02
7-epi-hydroxy Staurosporine
A PKC inhibitor
GC13877 1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol
GC17815 L-threo-Sphingosine C-18
L-threo-Sphingosine C-18
A D-erythro-sphingosine analog
GC13226 Bisindolylmaleimide VIII (acetate)
3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐,BIM VIII,Ro 31-7549
A PKC inhibitor
GC14716 Bisindolylmaleimide IV
双吲哚马来酰亚胺IV,Arcyriarubin A,BIM IV
Bisindolylmaleimide IV 是一种强效的细胞膜透过性蛋白激酶C(PKC)抑制剂，其IC₅₀值为0.1-0.55μM。
GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator 是一种细胞可渗透的苯并内酰胺衍生蛋白激酶 C (PKC) 激活剂，Ki 为 11.9 nM。
GC11050 ALK5 Inhibitor II (hydrochloride)
E 616452,RepSox,SJN 2511
A selective inhibitor of ALK5
GC15018 Hispidin
6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮
A polyphenol with diverse biological activities
GC16405 Safingol
沙芬戈,L-threo-Dihydrosphingosine,L-threo-Sphinganine
A dual inhibitor of PKC and SPHK
GC11022 SB 218078 A potent Chk1 inhibitor
GC10716 Netarsudil (AR-13324)
2,4-二甲基苯甲酸[4-[(1S)-1-(氨基甲基)-2-(6-异喹啉基氨基)-2-氧代乙基]苯基]甲基酯二盐酸盐
ROCK抑制剂
GC17191 SIS3 HCl
SIS3 盐酸盐
SIS3 HCl是一种Smad3抑制剂，可抑制Smad3 的磷酸化， IC₅₀ 为3 μM。
GC13273 ZIP ZIP 是 PKMζ 的选择性肽抑制剂。
GC17239 Bisindolylmaleimide V
双吲哚马来酰亚胺,BIM V
A S6K inhibitor
GC10029 Ro 31-8220 methanesulfonate
Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate
Inhibitor of protein kinase C
GC10607 GNF-7 A multi-kinase inhibitor
GC17901 Tamoxifen
他莫昔芬; ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。
GC15884 Dasatinib Monohydrate
达沙替尼一水合物,BMS-354825 monohydrate
An inhibitor of Abl and Src
GC13354 EW-7197
Vactosertib，TEW-7197
A potent inhibitor of ALK5
GC12402 LX7101 HCL A LIMK and ROCK inhibitor
GC12108 ITD 1 An inhibitor of TGF-β
GC11140 Radotinib(IY-5511)
拉多替尼
A selective Bcr-Abl tyrosine kinase inhibitor
GC17242 (-)-epigallocatechin
(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
A green tea polyphenol
GC10603 (-)-epicatechin gallate
表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate
A natural polyphenol with diverse protective actions
GC12695 Bryostatin 3 Bryostatin 3 是一种大环内酯，是一种蛋白激酶 C 激活剂，Ki 为 2.75 nM。 Bryostatin 3 可以阻断 12-O-tetradecanoylphorbol-13-acetate (TPA) 对细胞增殖的抑制作用，但不能阻断 TPA 增强的细胞-基质粘附。
GC12842 Bryostatin 2 Protein kinase C (PKC) activator
GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
GC16289 SAR407899 hydrochloride
6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐
A ROCK1 and ROCK2 inhibitor
GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor
GC16475 Afuresertib
GSK2110183
A pan-Akt inhibitor
GC12817 K-115 hydrochloride dihydrate
(2S)-1-[(4-氟-5-异喹啉基)磺酰基]六氢-2-甲基-1H-1,4-二氮杂卓单盐酸盐二水合物,K-115
K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
GC14012 (-)-Indolactam V
吲哚内酰胺V,Indolactam V
A PKC activator
GC10682 TAS 301
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮
An inhibitor of Ca²⁺ mobilization and CaM kinase II
GC15057 Kartogenin
2-([1,1-联苯]-4-基氨基甲酰)苯甲酸,KGN
A potent inducer of chondrocyte differentiation
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC12135 Bisindolylmaleimide II
双吲哚马来酰亚胺II,Bis II
A PKC inhibitor
GC14583 R 59-022
DKGI-I; Diacylglycerol kinase inhibitor I

A DGK inhibitor
GC10820 Rottlerin
粗糠柴苦素,Mallotoxin; NSC 56346; NSC 94525
An inhibitor of PKCδ and other protein kinases
GC11605 C-1
1-(5-异喹啉磺酰基)哌嗪盐酸盐
C-1 是一种有效的蛋白激酶抑制剂，IC50 为 4 μM, 8 μM, 12 μM 和 240 μM 用于 cGMP 依赖性蛋白激酶 (PKG)、cAMP 依赖性蛋白激酶 (PKA) ，分别为蛋白激酶 C (PKC) 和 MLC 激酶。 C-1 也用作 ROCK 抑制剂。
GC18055 SC-9
NCM 119
An activator of PKC
GC13320 SC-10 Protein kinase C activator
GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached
GC15345 [Ala113]-MBP (104-118)
肽抑制剂[ALA113]-MBP(104-118)
[Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 28-62 μM。
GC17727 [Ala107]-MBP (104-118)
肽抑制剂[ALA107]-MBP(104-118)
[Ala107]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 46-145 μM。
GC11671 PKC fragment (530-558) Potent activator of protein kinase C