TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for TGF-β / Smad Signaling

Cat.No. 产品名称 Information
GC12842 Bryostatin 2 Protein kinase C (PKC) activator
GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
GC16289 SAR407899 hydrochloride
6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐
A ROCK1 and ROCK2 inhibitor
GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor
GC16475 Afuresertib
GSK2110183
A pan-Akt inhibitor
GC12817 K–115 hydrochloride dihydrate
(2S)-1-[(4-氟-5-异喹啉基)磺酰基]六氢-2-甲基-1H-1,4-二氮杂卓单盐酸盐二水合物,K-115
K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
GC14012 (-)-Indolactam V
吲哚内酰胺V,Indolactam V
A PKC activator
GC10682 TAS 301
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮
An inhibitor of Ca²⁺ mobilization and CaM kinase II
GC15057 Kartogenin
2-([1,1-联苯]-4-基氨基甲酰)苯甲酸,KGN
A potent inducer of chondrocyte differentiation
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC12135 Bisindolylmaleimide II
双吲哚马来酰亚胺II,Bis II
A PKC inhibitor
GC14583 R 59-022
DKGI-I; Diacylglycerol kinase inhibitor I
A DGK inhibitor
GC10820 Rottlerin
粗糠柴苦素,Mallotoxin; NSC 56346; NSC 94525
An inhibitor of PKCδ and other protein kinases
GC11605 C-1
1-(5-异喹啉磺酰基)哌嗪盐酸盐
C-1 是一种有效的蛋白激酶抑制剂，IC50 为 4 μM, 8 μM, 12 μM 和 240 μM 用于 cGMP 依赖性蛋白激酶 (PKG)、cAMP 依赖性蛋白激酶 (PKA) ，分别为蛋白激酶 C (PKC) 和 MLC 激酶。 C-1 也用作 ROCK 抑制剂。
GC18055 SC-9
NCM 119
An activator of PKC
GC13320 SC-10 Protein kinase C activator
GC16510 ZIP, Biotinylated ZIP with a biotin moiety covalently attached
GC15345 [Ala113]-MBP (104-118)
肽抑制剂[ALA113]-MBP(104-118)
[Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 28-62 μM。
GC17727 [Ala107]-MBP (104-118)
肽抑制剂[ALA107]-MBP(104-118)
[Ala107]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 46-145 μM。
GC11671 PKC fragment (530-558) Potent activator of protein kinase C
GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C
GC10404 PKC ζ pseudosubstrate PKC &zeta； pseudosubstrate 是一种选择性的细胞渗透性 PKC 抑制剂。
GC11803 Pseudo RACK1 Activator of protein kinase C
GC15148 Ionomycin calcium salt
罗红霉素钙盐(链霉菌属载体),SQ23377 calcium
Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。
GC17563 LY 333531 hydrochloride
LY333531 hydrochloride
A PKCβ inhibitor
GC17352 Phorbol 12,13-dibutyrate
Phorbol dibutyrate; PDBu
An activator of PKC
GC12027 FR 236924
FR236924
An activator of PKCε
GC10687 CGP 53353
DAPH-7
CGP 53353 (DAPH-7) 是一种有效的 PKC 抑制剂，对 PKCβII 和 PKCβI 的 IC50 分别为 0.41 mM 和 3.8 mM。
GC17670 Bryostatin 1
苔藓抑素1
A marine macrolide with diverse biological activities
GC15446 Ionomycin free acid
离子霉素,SQ23377
Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。
GC11362 K 252a
SF 2370
A non-selective PKC inhibitor
GC11159 Calphostin C
抑制剂C,UCN-1028C
A selective PKC inhibitor
GC13677 Ro 32-0432 hydrochloride
(S)-3-[8-[(二甲基氨基)甲基]-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
Ro 32-0432 hydrochloride 是一种有效的、选择性的、ATP 竞争性和口服活性的 PKC 抑制剂。
GC17346 KT 5823
蛋白激酶仰制剂KT5823
Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
GC17767 Dihydrosphingosine
二氢(神经)鞘氨醇
A mixture of sphingolipid pathway intermediates
GC17591 D-erythro-Sphingosine (synthetic)
鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
GC13890 (±)-Palmitoylcarnitine chloride
C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine
A long-chain acylcarnitine with intracellular and extracellular roles
GC17712 AT13148 A multi-AGC kinase inhibitor
GC10496 Midostaurin (PKC412)
米哚妥林; PKC412; CGP 41251
Kinase inhibitor with potential use in cancer treatment
GC17582 ML347
LDN 193719
A selective ALK1 and ALK2 inhibitor
GC17035 LDN-212854
5-（6-（4-（哌嗪-1-基）苯基）吡唑并[1,5-a]嘧啶-3-基）喹啉
An ALK2 inhibitor
GC14298 DMH-1
BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482
A potent ALK2 inhibitor
GC13869 Fasudil
法舒地尔; HA-1077; AT877
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC16934 Valrubicin
戊柔比星; AD-32
A semisynthetic anthracycline antitumor antibiotic
GC13461 ZIP (SCRAMBLED)
加扰控制肽,z-Pseudosubstrate inhibitory peptide
ZIP (SCRAMBLED) 是 zeta 抑制肽 (ZIP) 的乱序对照肽。
GC17936 GSK269962A
N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺,GSK 269962
A ROCK1 and ROCK2 inhibitor
GC12790 Pirfenidone
吡非尼酮; AMR69
吡非尼酮（Pirfenidone；AMR69）是一种具有口服活性的抗纤维化药物，可减弱纤维细胞中趋化因子CCL2和CCL12的产生。
GC14363 Mitoxantrone HCl
米托蒽醌二盐酸盐; Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
GC11604 LY364947
HTS466284
Inhibitor of TGF-β type-1 receptors
GC16354 Dequalinium Chloride
地喹氯铵
An ammonium cation with diverse biological activities