TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for TGF-β / Smad Signaling

Cat.No. 产品名称 Information
GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C
GC10404 PKC ζ pseudosubstrate PKC &zeta； pseudosubstrate 是一种选择性的细胞渗透性 PKC 抑制剂。
GC11803 Pseudo RACK1 Activator of protein kinase C
GC15148 Ionomycin calcium salt
罗红霉素钙盐(链霉菌属载体),SQ23377 calcium
Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。
GC17563 LY 333531 hydrochloride
LY333531 hydrochloride
A PKCβ inhibitor
GC17352 Phorbol 12,13-dibutyrate
Phorbol dibutyrate; PDBu
An activator of PKC
GC12027 FR 236924
FR236924
An activator of PKCε
GC10687 CGP 53353
DAPH-7
CGP 53353 (DAPH-7) 是一种有效的 PKC 抑制剂，对 PKCβII 和 PKCβI 的 IC50 分别为 0.41 mM 和 3.8 mM。
GC17670 Bryostatin 1
苔藓抑素1
A marine macrolide with diverse biological activities
GC15446 Ionomycin free acid
离子霉素,SQ23377
Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。
GC11362 K 252a
SF 2370
A non-selective PKC inhibitor
GC11159 Calphostin C
抑制剂C,UCN-1028C
A selective PKC inhibitor
GC13677 Ro 32-0432 hydrochloride
(S)-3-[8-[(二甲基氨基)甲基]-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮
Ro 32-0432 hydrochloride 是一种有效的、选择性的、ATP 竞争性和口服活性的 PKC 抑制剂。
GC17346 KT 5823
蛋白激酶仰制剂KT5823

Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
GC17767 Dihydrosphingosine
二氢(神经)鞘氨醇
A mixture of sphingolipid pathway intermediates
GC17591 D-erythro-Sphingosine (synthetic)
鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
GC13890 (±)-Palmitoylcarnitine chloride
C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine
A long-chain acylcarnitine with intracellular and extracellular roles
GC17712 AT13148 A multi-AGC kinase inhibitor
GC10496 Midostaurin (PKC412)
米哚妥林; PKC412; CGP 41251
Kinase inhibitor with potential use in cancer treatment
GC17582 ML347
LDN 193719
A selective ALK1 and ALK2 inhibitor
GC17035 LDN-212854
5-（6-（4-（哌嗪-1-基）苯基）吡唑并[1,5-a]嘧啶-3-基）喹啉
An ALK2 inhibitor
GC14298 DMH-1
BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482
A potent ALK2 inhibitor
GC13869 Fasudil
法舒地尔; HA-1077; AT877
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC16934 Valrubicin
戊柔比星; AD-32
A semisynthetic anthracycline antitumor antibiotic
GC13461 ZIP (SCRAMBLED)
加扰控制肽,z-Pseudosubstrate inhibitory peptide
ZIP (SCRAMBLED) 是 zeta 抑制肽 (ZIP) 的乱序对照肽。
GC17936 GSK269962A
N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺,GSK 269962
A ROCK1 and ROCK2 inhibitor
GC12790 Pirfenidone
吡非尼酮; AMR69
吡非尼酮（Pirfenidone；AMR69）是一种具有口服活性的抗纤维化药物，可减弱纤维细胞中趋化因子CCL2和CCL12的产生。
GC14363 Mitoxantrone HCl
米托蒽醌二盐酸盐; Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
GC11604 LY364947
HTS466284
Inhibitor of TGF-β type-1 receptors
GC16354 Dequalinium Chloride
地喹氯铵
An ammonium cation with diverse biological activities
GC17523 Hydrochlorothiazide
氢氯噻嗪; HCTZ
A thiazide diuretic
GC10314 Imatinib (STI571)
伊马替尼; STI571; CGP-57148B
伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
GC17322 Ro 31-8220
Bisindolylmaleimide IX
Ro 31-8220 是一种有效的 PKC 抑制剂，对 PKCα、PKCβI、PKCβII、PKCγ、PKCε 和大鼠脑 PKC 的 IC50 分别为 5、24、14、27、24 和 23 nM。
GC13769 SB505124 Inhibitor of receptors ALK4, ALK5, and ALK7
GC10722 SR-3677
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
A ROCK1 and ROCK2 inhibitor
GC14007 DCC-2036 (Rebastinib)
N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲,DCC-2036
An orally bioavailable tyrosine kinase inhibitor
GC15712 Y-27632 A ROCK inhibitor
GC13423 Y-39983 dihydrochloride ROCK family inhibitor
GC13232 Verbascoside
麦角甾苷; Acteoside; Kusaginin; TJC160
A natural phenylpropanoid glucoside with diverse biological activities
GC17243 Dorsomorphin (Compound C)
6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Compound C
Dorsomorphin（Compound C）是一种细胞渗透的AMPK抑制剂。
GC15567 K02288 A BMP signaling inhibitor
GC10915 GZD824
GZD824 dimesylate; HQP1351 dimesylate
A Bcr/Abl inhibitor
GC12560 Dorsomorphin (Compound C) 2HCl
BML-275 2HCl,Compound C 2HCl
IC50:Dorsomorphin 以剂量依赖性方式抑制 BMP4 诱导的 BMP 反应性 SMAD 磷酸化（半数最大抑制浓度 (IC50) =0.47 mM）。
GC13592 PD173955
6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-D]嘧啶-7(8H)-酮
A tyrosine kinase inhibitor
GC15420 ICP 103 Protein kinase inhibitor
GC14407 PF-431396
N-甲基-N-[2-[[[2-[(2-氧代-2,3-二氢-1H-吲哚-5-基)氨基]-5-三氟甲基嘧啶-4-基]氨基]甲基]苯基]甲磺酰胺
A FAK/PYK2 dual inhibitor
GC13914 Flumatinib mesylate
甲磺酸氟马替尼; HHGV678 mesylate
A Bcr-Abl inhibitor
GC12779 PPY A PPY A 是一种有效的 T315I 突变体和野生型 Abl 激酶抑制剂，IC50 分别为 9 和 20 nM。 PPY A 抑制用野生型 Abl 和 Abl T315I 突变体转化的 Ba⁄F3 细胞，IC50 分别为 390 和 180 nM。 PPY A可用于慢性粒细胞白血病（CML）的研究。
GC12637 PD 180970 An inhibitor of Bcr-Abl
GC12172 1-Naphthyl PP1
4-氨基-1-叔丁基-3-(1'-萘基)吡唑并[3,4-D]嘧啶,1-NA-PP 1
Inhibitor of modified ‘analog-sensitive’ kinases