PKC(蛋白激酶C)
PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.
Products for PKC
- Cat.No. 产品名称 Information
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GC43286
CMPD101
A GRK2 and GRK3 inhibitor
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GC43105
C8 Ceramide (d18:1.8:0)
N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine
A cell-permeable ceramide analog -
GC42747
Afuresertib (hydrochloride)
GSK2110183 hydrochloride
A pan-Akt inhibitor -
GC40770
L-erythro Sphingosine (d18:1)
双琥珀酰亚胺辛二酸酯
A bioactive sphingolipid -
GC32870
Ingenol ((-)-Ingenol)
巨大戟醇; (-)-Ingenol
A PKC activator -
GC32811
LXS196
LXS196; IDE196
A PKC inhibitor -
GC32714
Mitoxantrone (mitozantrone)
米托蒽醌; Mitozantrone; NSC 301739
米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。 -
GC31959
AS2521780
AS2521780是新颖的PKCθ选择性抑制剂,IC50值为0.48nM。
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GC31912
VTX-27
A PKCθ inhibitor
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GC31892
Decursin ((+)-Decursin)
紫花前胡素; (+)-Decursin
A phytochemical with diverse biological activities -
GC31711
PKC-IN-1
[(2S,5R)-2,5-二甲基-4-[(四氢-2H-吡喃-4-基)甲基]-1-哌嗪基][3-[(5-氟-2-甲基-4-嘧啶基)氨基]-4,6-二氢-6,6-二甲基吡咯并[3,4-C]吡唑-5(1H)-基]甲酮
PKC-IN-1是一种有效的,ATP-竞争性的,可逆的PKC抑制剂,对人PKCβ和PKCα的Ki值分别为5.3和10.4nM,对人PKCα,PKCβI,PKCβII,PKCθ,PKCγ,PKCmu和PKCε的IC50值分别为2.3,8.1,7.6,25.6,57.5,314,808nM。 -
GC31656
Ingenol Mebutate (Ingenol 3-angelate)
巨大戟醇甲基丁烯酸酯; Ingenol 3-angelate; PEP005
A natural cytotoxic diterpene ester -
GC30545
Malantide
Malantide是一种十二肽,能够被PKA磷酸化,并且能够增强PKA的活性。
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GC30200
PKC-theta inhibitor
PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.
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GC18521
Cercosporin
尾孢菌素
A cytotoxic phytotoxin -
GC18354
Bisindolylmaleimide X (hydrochloride)
BIM-X hydrochloride; Ro31-8425 hydrochloride
A PKC inhibitor -
GC18246
R-59-949
Diacylglycerol Kinase Inhibitor II, DKGI-II
A DGK-α inhibitor -
GC14134
1,2-Dimyristoyl-sn-glycerol
1,2-二肉豆蔻酸甘油酯,1,2-DMG
A long-chain DAG -
GC18062
1,2-Dilauroyl-sn-glycerol
1,2-二月桂酰-SN-甘油,1,2-DLG
A long-chain DAG -
GC12662
1,2-Distearoyl-sn-glycerol
1,2-Dioctadecanoyl-sn-glycerol,DSG
A diacylglycerol -
GC10299
Hexadecyl Methyl Glycerol
1-O-hexadecyl-2-O-methyl-sn-Glycerol
A synthetic DAG -
GC16678
UCN-02
7-epi-hydroxy Staurosporine
A PKC inhibitor -
GC13877
1,2-Dipalmitoyl-sn-glycerol
1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964
A diacylglycerol -
GC17815
L-threo-Sphingosine C-18
L-threo-Sphingosine C-18
A D-erythro-sphingosine analog -
GC13226
Bisindolylmaleimide VIII (acetate)
3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐,BIM VIII,Ro 31-7549
A PKC inhibitor -
GC14716
Bisindolylmaleimide IV
双吲哚马来酰亚胺IV,Arcyriarubin A,BIM IV
A PKC inhibitor -
GC10343
α-Amyloid Precursor Protein Modulator
α-Amyloid Precursor Protein Modulator 是一种细胞可渗透的苯并内酰胺衍生蛋白激酶 C (PKC) 激活剂,Ki 为 11.9 nM。
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GC15018
Hispidin
6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮
A polyphenol with diverse biological activities -
GC16405
Safingol
沙芬戈,L-threo-Dihydrosphingosine,L-threo-Sphinganine
A dual inhibitor of PKC and SPHK -
GC11022
SB 218078
A potent Chk1 inhibitor
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GC13273
ZIP
ZIP 是 PKMζ 的选择性肽抑制剂。
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GC17239
Bisindolylmaleimide V
双吲哚马来酰亚胺,BIM V
A S6K inhibitor -
GC10029
Ro 31-8220 methanesulfonate
Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate
Inhibitor of protein kinase C -
GC17242
(-)-epigallocatechin
(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
A green tea polyphenol -
GC10603
(-)-epicatechin gallate
表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate
A natural polyphenol with diverse protective actions -
GC12695
Bryostatin 3
Bryostatin 3 是一种大环内酯,是一种蛋白激酶 C 激活剂,Ki 为 2.75 nM。 Bryostatin 3 可以阻断 12-O-tetradecanoylphorbol-13-acetate (TPA) 对细胞增殖的抑制作用,但不能阻断 TPA 增强的细胞-基质粘附。
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GC12842
Bryostatin 2
Protein kinase C (PKC) activator
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GC16475
Afuresertib
GSK2110183
A pan-Akt inhibitor -
GC14012
(-)-Indolactam V
吲哚内酰胺V,Indolactam V
A PKC activator -
GC10682
TAS 301
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮
An inhibitor of Ca2+ mobilization and CaM kinase II -
GC12135
Bisindolylmaleimide II
双吲哚马来酰亚胺II,Bis II
A PKC inhibitor -
GC14583
R 59-022
DKGI-I; Diacylglycerol kinase inhibitor I
A DGK inhibitor -
GC10820
Rottlerin
粗糠柴苦素,Mallotoxin; NSC 56346; NSC 94525
An inhibitor of PKCδ and other protein kinases -
GC11605
C-1
1-(5-异喹啉磺酰基)哌嗪盐酸盐
C-1 是一种有效的蛋白激酶抑制剂,IC50 为 4 μM, 8 μM, 12 μM 和 240 μM 用于 cGMP 依赖性蛋白激酶 (PKG)、cAMP 依赖性蛋白激酶 (PKA) ,分别为蛋白激酶 C (PKC) 和 MLC 激酶。 C-1 也用作 ROCK 抑制剂。 -
GC18055
SC-9
NCM 119
An activator of PKC -
GC13320
SC-10
Protein kinase C activator
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GC16510
ZIP, Biotinylated
ZIP with a biotin moiety covalently attached
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GC15345
[Ala113]-MBP (104-118)
肽抑制剂[ALA113]-MBP(104-118)
[Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂,IC50 范围为 28-62 μM。 -
GC17727
[Ala107]-MBP (104-118)
肽抑制剂[ALA107]-MBP(104-118)
[Ala107]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂,IC50 范围为 46-145 μM。 -
GC11671
PKC fragment (530-558)
Potent activator of protein kinase C