PKC(蛋白激酶C)

Cat.No. 产品名称 Information

GC43105 C8 Ceramide (d18:1.8:0)

N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

A cell-permeable ceramide analog

GC42747 Afuresertib (hydrochloride)

GSK2110183 hydrochloride

A pan-Akt inhibitor

GC40770 L-erythro Sphingosine (d18:1)

双琥珀酰亚胺辛二酸酯

A bioactive sphingolipid

GC32870 Ingenol ((-)-Ingenol)

巨大戟醇; (-)-Ingenol

A PKC activator

GC32811 LXS196

LXS196; IDE196

A PKC inhibitor

GC32714 Mitoxantrone (mitozantrone)

米托蒽醌; Mitozantrone; NSC 301739

米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。

GC31959 AS2521780 AS2521780是新颖的PKCθ选择性抑制剂，IC50值为0.48nM。

GC31912 VTX-27 A PKCθ inhibitor

GC31892 Decursin ((+)-Decursin)

紫花前胡素; (+)-Decursin

A phytochemical with diverse biological activities

GC31711 PKC-IN-1

[(2S,5R)-2,5-二甲基-4-[(四氢-2H-吡喃-4-基)甲基]-1-哌嗪基][3-[(5-氟-2-甲基-4-嘧啶基)氨基]-4,6-二氢-6,6-二甲基吡咯并[3,4-C]吡唑-5(1H)-基]甲酮

PKC-IN-1是一种有效的，ATP-竞争性的，可逆的PKC抑制剂，对人PKCβ和PKCα的Ki值分别为5.3和10.4nM，对人PKCα，PKCβI，PKCβII，PKCθ，PKCγ，PKCmu和PKCε的IC50值分别为2.3，8.1，7.6，25.6，57.5，314，808nM。

GC31656 Ingenol Mebutate (Ingenol 3-angelate)

巨大戟醇甲基丁烯酸酯; Ingenol 3-angelate; PEP005

A natural cytotoxic diterpene ester

GC30545 Malantide Malantide是一种十二肽，能够被PKA磷酸化，并且能够增强PKA的活性。

GC30200 PKC-theta inhibitor PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.

GC18521 Cercosporin

尾孢菌素

A cytotoxic phytotoxin

GC18354 Bisindolylmaleimide X (hydrochloride)

BIM-X hydrochloride; Ro31-8425 hydrochloride

A PKC inhibitor

GC18246 R-59-949

Diacylglycerol Kinase Inhibitor II, DKGI-II

A DGK-α inhibitor

GC14134 1,2-Dimyristoyl-sn-glycerol

1,2-二肉豆蔻酸甘油酯,1,2-DMG

A long-chain DAG

GC18062 1,2-Dilauroyl-sn-glycerol

1,2-二月桂酰-SN-甘油,1,2-DLG

A long-chain DAG

GC12662 1,2-Distearoyl-sn-glycerol

1,2-Dioctadecanoyl-sn-glycerol,DSG

A diacylglycerol

GC10299 Hexadecyl Methyl Glycerol

1-O-hexadecyl-2-O-methyl-sn-Glycerol

A synthetic DAG

GC16678 UCN-02

7-epi-hydroxy Staurosporine

A PKC inhibitor

GC13877 1,2-Dipalmitoyl-sn-glycerol

1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964

A diacylglycerol

GC17815 L-threo-Sphingosine C-18

L-threo-Sphingosine C-18

A D-erythro-sphingosine analog

GC13226 Bisindolylmaleimide VIII (acetate)

3-[1-(3-氨基丙基)-1H-吲哚-3-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮单乙酸盐,BIM VIII,Ro 31-7549

A PKC inhibitor

GC14716 Bisindolylmaleimide IV

双吲哚马来酰亚胺IV,Arcyriarubin A,BIM IV

Bisindolylmaleimide IV 是一种强效的细胞膜透过性蛋白激酶C(PKC)抑制剂，其IC₅₀值为0.1-0.55μM。

GC10343 α-Amyloid Precursor Protein Modulator α-Amyloid Precursor Protein Modulator 是一种细胞可渗透的苯并内酰胺衍生蛋白激酶 C (PKC) 激活剂，Ki 为 11.9 nM。

GC15018 Hispidin

6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮

A polyphenol with diverse biological activities

GC16405 Safingol

沙芬戈,L-threo-Dihydrosphingosine,L-threo-Sphinganine

A dual inhibitor of PKC and SPHK

GC11022 SB 218078 A potent Chk1 inhibitor

GC13273 ZIP ZIP 是 PKMζ 的选择性肽抑制剂。

GC17239 Bisindolylmaleimide V

双吲哚马来酰亚胺,BIM V

A S6K inhibitor

GC10029 Ro 31-8220 methanesulfonate

Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate

Inhibitor of protein kinase C

GC17242 (-)-epigallocatechin

(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin

A green tea polyphenol

GC10603 (-)-epicatechin gallate

表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate

A natural polyphenol with diverse protective actions

GC12695 Bryostatin 3 Bryostatin 3 是一种大环内酯，是一种蛋白激酶 C 激活剂，Ki 为 2.75 nM。 Bryostatin 3 可以阻断 12-O-tetradecanoylphorbol-13-acetate (TPA) 对细胞增殖的抑制作用，但不能阻断 TPA 增强的细胞-基质粘附。