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Home >> Signaling Pathways >> TGF-β / Smad Signaling >> PKC

PKC(蛋白激酶C)

PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.

Products for  PKC

  1. Cat.No. 产品名称 Information
  2. GC15471 PKC β pseudosubstrate Selective cell-permeable peptide inhibitor of protein kinase C
  3. GC10404 PKC ζ pseudosubstrate PKC &zeta； pseudosubstrate 是一种选择性的细胞渗透性 PKC 抑制剂。
  4. GC11803 Pseudo RACK1 Activator of protein kinase C
  5. GC15148 Ionomycin calcium salt

    罗红霉素钙盐(链霉菌属载体),SQ23377 calcium

     Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。
  6. GC17563 LY 333531 hydrochloride

    LY333531 hydrochloride

     A PKCβ inhibitor
  7. GC17352 Phorbol 12,13-dibutyrate

    Phorbol dibutyrate; PDBu

     An activator of PKC
  8. GC12027 FR 236924

    FR236924

     An activator of PKCε
  9. GC10687 CGP 53353

    DAPH-7

     CGP 53353 (DAPH-7) 是一种有效的 PKC 抑制剂，对 PKCβII 和 PKCβI 的 IC50 分别为 0.41 mM 和 3.8 mM。
  10. GC17670 Bryostatin 1

    苔藓抑素1

     A marine macrolide with diverse biological activities
  11. GC15446 Ionomycin free acid

    离子霉素,SQ23377

     Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。
  12. GC11362 K 252a

    SF 2370

     A non-selective PKC inhibitor
  13. GC11159 Calphostin C

    抑制剂C,UCN-1028C

     A selective PKC inhibitor
  14. GC13677 Ro 32-0432 hydrochloride

    (S)-3-[8-[(二甲基氨基)甲基]-6,7,8,9-四氢吡啶并[1,2-A]吲哚-10-基]-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮

     Ro 32-0432 hydrochloride 是一种有效的、选择性的、ATP 竞争性和口服活性的 PKC 抑制剂。
  15. GC17346 KT 5823

    蛋白激酶仰制剂KT5823

     Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
  16. GC17767 Dihydrosphingosine

    二氢(神经)鞘氨醇

     A mixture of sphingolipid pathway intermediates
  17. GC17591 D-erythro-Sphingosine (synthetic)

    鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine

     D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
  18. GC13890 (±)-Palmitoylcarnitine chloride

    C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine

     A long-chain acylcarnitine with intracellular and extracellular roles
  19. GC10496 Midostaurin (PKC412)

    米哚妥林; PKC412; CGP 41251

     Kinase inhibitor with potential use in cancer treatment
  20. GC13869 Fasudil

    法舒地尔; HA-1077; AT877

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  21. GC16934 Valrubicin

    戊柔比星; AD-32

     A semisynthetic anthracycline antitumor antibiotic
  22. GC13461 ZIP (SCRAMBLED)

    加扰控制肽,z-Pseudosubstrate inhibitory peptide

     ZIP (SCRAMBLED) 是 zeta 抑制肽 (ZIP) 的乱序对照肽。
  23. GC14363 Mitoxantrone HCl

    米托蒽醌二盐酸盐; Mitozantrone dihydrochloride; NSC 301739 dihydrochloride

     An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
  24. GC16354 Dequalinium Chloride

    地喹氯铵

     An ammonium cation with diverse biological activities
  25. GC17322 Ro 31-8220

    Bisindolylmaleimide IX

     Ro 31-8220 是一种有效的 PKC 抑制剂，对 PKCα、PKCβI、PKCβII、PKCγ、PKCε 和大鼠脑 PKC 的 IC50 分别为 5、24、14、27、24 和 23 nM。
  26. GC13232 Verbascoside

    麦角甾苷; Acteoside; Kusaginin; TJC160

     A natural phenylpropanoid glucoside with diverse biological activities
  27. GC15420 ICP 103 Protein kinase inhibitor
  28. GC15520 Sotrastaurin (AEB071)

    3-(1H-吲哚-3-基)-4-[2-(4-甲基哌嗪-1-基)喹唑啉-4-基]吡咯-2,5-二酮,AEB 071;AEB-071

     A PKC and GSK3 inhibitor
  29. GC15281 K-252c

    孢菌素甙元,Staurosporinone

     A cell-permeable PKC inhibitor
  30. GC16907 Go 6983

    3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮,Goe 6983;Go6983;Go-6983

     Go 6983 (GÖ 6983) 是 PKC 抑制剂化合物的双吲哚基马来酰亚胺组之一，Go 6983 (GÖ 6983) 能够区分 PKC mu 和其他 PKC 同工酶。
  31. GC15431 GF 109203X (Bisindolylmaleimide I)

    Gö 6850;Bisindolylmaleimide I

     A PKC inhibitor
  32. GC15564 Go 6976

    5,6,7,13-四氢-13-甲基-5-氧代-12H-吲哚并[2,3-A]吡咯并[3,4-C]咔唑-12-丙腈,Go6976;Go-6976

     A PKCα/β1 inhibitor
  33. GC14289 Fasudil (HA-1077) HCl

    盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  34. GC14701 Zoledronic Acid

    唑来膦酸; Zoledronate; CGP 42446; CGP42446A; ZOL 446

     A bisphosphonate that inhibits bone resorption
  35. GC11499 Enzastaurin (LY317615)

    恩扎妥林; LY317615

     An inhibitor of PKC and Akt signaling
  36. GC16584 TCS 21311

    NIBR3049

     A JAK3 inhibitor
  37. GC13065 Chelerythrine Chloride

    盐酸白屈菜红碱

     Potent inhibitor of PKC and Bcl-xL
  38. GC14650 CGP60474

    3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇,CGP-60474;CGP 60474

     A CDK inhibitor
  39. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    佛波酯; PMA; TPA; Phorbol myristate acetate

    一种PKC激活剂
  40. GN10336 Daphnetin

    瑞香素; 7,8-Dihydroxycoumarin

     A coumarin derivative with diverse biological activities
  41. GN10463 Chelerythrine

    白屈菜红碱

     Chelerythrine 是一种天然生物碱，是一种有效的选择性 Ca2+/磷脂依赖性 PKC 拮抗剂，IC50 为 0.7 μM。
  42. GC15299 Staurosporine(CGP 41251)

    星形孢菌素; Antibiotic AM-2282; STS; AM-2282

     Staurosporin 是一种小激酶抑制剂，是一种从细菌 Streptomyces staurosporeus 中提取的生物碱。
  43. GC14049 (-)-Epigallocatechin gallate (EGCG)

    (-)-表没食子儿茶素没食子酸酯,EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。

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