Bcr-Abl(Bcr-Abl酪氨酸激酶)

Bcl-Abl is a constitutively activated chimeric tyrosine kinase which is the genetic abnormality expressed in patient with CML (chronic myeloid leukemia).

Products for Bcr-Abl

Cat.No. 产品名称 Information
GC14396 Ponatinib (AP24534)
普纳替尼; AP24534
An inhibitor of native and mutant Bcr-Abl
GC15197 Saracatinib (AZD0530)
塞卡替尼; AZD0530
A dual inhibitor of c-Src and Abl
GC11759 Imatinib Mesylate (STI571)
甲磺酸伊马替尼; STI571 Mesylate; CGP-57148B Mesylate
An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
GC13343 Bosutinib (SKI-606)
伯舒替尼,SKI-606
An inhibitor of Src and Abl kinases
GC14129 Nilotinib(AMN-107)
尼洛替尼; AMN107
Nilotinib(AMN-107)（尼洛替尼）是一种选择性口服酪氨酸激酶抑制剂，可抑制天然Bcr-Abl（WT p210）和突变型Bcr-Abl（E281K、E292K、F317L、M351T和F486S）的自磷酸化，IC₅₀值分别为20、42、31、38、29和41nM。
GC13102 XL228
N4-(5-环丙基-1H-吡唑-3-基)-N2-[[3-异丙基-5-异恶唑基]甲基]-6-(4-甲基-1-哌嗪基)-2,4-嘧啶二胺,XL-228;XL 228
A tyrosine kinase inhibitor
GC14237 Nilotinib monohydrochloride monohydrate
尼洛替尼盐酸盐一水合物; AMN107 monohydrochloride monohydrate
A Bcr-Abl inhibitor
GC10914 AST 487
NVP-AST 487
A multi-kinase inhibitor
GC14592 KW 2449
[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮
A multi-kinase inhibitor
GC10638 AT9283 A broad spectrum kinase inhibitor
GC15568 Dasatinib (BMS-354825)
达沙替尼; BMS-354825
An inhibitor of Abl and Src