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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information
GC35436 AV-412 free base
MP-412 free base
A dual inhibitor of EGFR and HER2
GC35435 AV-412
MP412
A dual inhibitor of EGFR and HER2
GC35413 Astragaloside VI
黄芪皂苷VI
Astragaloside VI 可通过激活表皮生长因子受体/细胞外信号调节激酶 (EGFR/ERK) 信号通路来加速伤口愈合。
GC35315 AMG 925 HCl A dual inhibitor of FLT3 and Cdk4
GC35290 ALK-IN-6 ALK-IN-6 (compound 11) 是口服有效的，间变性淋巴瘤激酶 (ALK) 的抑制剂，其对野生型 ALK、ALK F1196M 和ALK F1174L 的 IC50 值分别为 71 nM、18.72 nM 和36.81 nM。
GC35289 ALK-IN-5 ALK-IN-5 是一种高效选择性的，可渗透大脑屏障的 (ALK) 激酶抑制剂，IC50 值为 2.9 nM。
GC35287 ALK inhibitor 1
2-[[5-溴-2-[[2-甲氧基-4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]-N-甲基苯磺酰胺
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
GC35280 Alectinib Hydrochloride
艾乐替尼盐酸盐; CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride
Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
GC35263 AG-13958
N-[2-氟-5-[[3-[(1E)-2-(2-吡啶基)乙烯基]-1H-吲唑-6-基]氨基]苯基]-1,3-二甲基-1H-吡唑-5-甲酰胺,AG-013958
AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD).
GC35225 AC710 Mesylate A PDGFR family kinase inhibitor
GC35214 A-9758 A-9758 是一种 RORγ 配体和一种有效选择性的 RORγt 反向激动剂 (IC50 值为 5 nM)，并且强效抑制 IL-17A 释放。A-9758 有效抑制 Th17 分化和 Th17 效应子功能。A-9758 显着减弱 IL-23 驱动型银屑病性皮炎，并有效阻断皮肤和关节炎症。
GC35213 A-770041 A LCK kinase inhibitor
GC35209 A 419259
RK-20449
An inhibitor of Src family kinases
GC35095 2-Phospho-L-ascorbic acid trisodium salt
L-抗坏血酸-2-磷酸三钠盐; 2-Phospho-L-ascorbic acid trisodium

Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.
GC35053 123C4 123C4 是一种有效、选择性的，竞争性受体酪氨酸激酶 EPHA4 激动剂，Ki 值为 0.65 μM.
GC19547 LOXO-292
塞尔帕替尼; LOXO-292;selpercatinib
A RET kinase inhibitor
GC45142 VEGFR2 Kinase Inhibitor II A potent, cell-permeable inhibitor of VEGFR2
GC44978 Syk Inhibitor II
Spleen Tyrosine Kinase Inhibitor II
A selective blocker of spleen tyrosine kinase activity
GC44977 Syk Inhibitor
OXSI 2, Spleen Tyrosine Kinase
Potently blocks spleen tyrosine kinase activity
GC44966 Sucrose octasulfate (potassium salt)
蔗糖八硫酸酯钾
An alkaline aluminum?sucrose complex
GC44958 SU 5205 An inhibitor of VEGFR2
GC44903 SMAD3 Inhibitor, SIS3 An inhibitor of TGF-β signaling
GC44806 Ras Inhibitory Peptide
Sos SH3 Domain Inhibitor
An inhibitor of activation of Ras
GC44613 PF-6274484 An EGFR inhibitor
GC44605 Petunidin (chloride)
矮牵牛素PT,Petunidol
An O-methylated anthocyanidin
GC44585 PD 174265 A potent, cell-permeable inhibitor of EGFR kinase
GC44583 PD 089828
EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor
An inhibitor of EGFR, PDGFβ, FGF, and c-Src
GC44491 O-Desmethyl Gefitinib
O-去甲基吉非替尼
A major active metabolite of gefitinib
GC44475 NVP-BEZ235 (hydrochloride)
Dactolisib
Dual inhibitor of PI3K and mTOR
GC44474 NVP-AEW541 (hydrochloride) An IGF-1R inhibitor
GC44358 Nebivolol O-β-D-Glucuronide An active metabolite of nebivolol
GC44290 NAADP (sodium salt)
Nicotinic acid adenine dinucleotide phosphate

A secondary messenger that induces calcium mobilization
GC44263 Myrtillin
氯化飞燕草素葡萄糖苷; Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride

桃金娘苷（Delphinidin 3-o-glucoside）是一种花青素单体，主要分布于各种植物中，可用高效液相色谱法（HPLC）质谱法（Mass）和核磁共振法进行定性和定量分析(NMR)。
GC44085 L-Sulforaphene
莱菔素
A natural isothiocyanate
GC44047 LDN-192960 (hydrochloride) An inhibitor of haspin and DYRK2
GC43885 Hypothemycin
寄端霉素
A resorcylic acid lactone polyketide with diverse biological activities
GC43795 GTP 14564 An inhibitor of class III receptor tyrosine kinases
GC43732 Ganglioside GM3 Mixture (sodium salt)
单唾液神经节苷酯GM3; Hematoside; Sialosyllactosylceramide
A mixture of ganglioside G_M3
GC43676 FLT3 Inhibitor III
Fms-like Tyrosine Kinase Inhibitor III
A potent, highly selective inhibitor of FLT3
GC43503 DMHAPC-Chol
Dimethyl Hydroxyethyl Aminopropane Carbamoyl Cholesterol Iodide
A cationic cholesterol
GC43433 D-Glucosamine-6-sulfate
D-氨基葡萄糖-6-硫酸盐
A glycosaminoglycan
GC43268 Cinnamtannin B-1
肉桂单宁B-1
A polyphenol antioxidant
GC43198 CAY10717 A multi-targeted kinase inhibitor
GC42972 Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)
Brain-derived aFGF (1-11)
A peptide fragment
GC42887 Axitinib Sulfoxide
阿西替尼杂质A
A major inactive metabolite of axitinib
GC42884 Avitinib
艾维替尼,Abivertinib; AC0010
A selective inhibitor of mutant EGFR
GC42616 7-oxo Staurosporine
BMY 41950, RK-1409
An antibiotic with diverse biological activities
GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
GC42026 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC
1-十六酰-SN-丙三醇-磷酸胆碱
A product of PLA₂-mediated hydrolysis of phosphatidylcholine
GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
(±)214,15EG
A cytochrome P450 metabolite of 2-AG