Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information

GC34488 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM.

GC34476 ASP5878 ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.

GC19509 Gefitinib-based PROTAC 3

Gefitinib-based Proteolysis-targeting Chimera 3

A PROTAC that drives mutant EGFR degradation

GC19508 BLU-782

Activin Receptor-like Kinase 2 Inhibitor 1, ALK2-IN-1, Fidrisertib

BLU-782 是一种口服精准疗法，专门设计用于选择性靶向突变体 ALK2。

GC40222 Lapatinib-d4 (tosylate) An internal standard for the quantification of lapatinib

GC40213 Regorafenib-13C-d3

瑞戈非尼-13C-D3,BAY 73-4506-13C,d3

An internal standard for the quantification of regorafenib

GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)

Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO

A non-selective caspase inhibitor

GC40085 Pazopanib-d6

培唑帕尼-d6,GW786034-d6

An internal standard for the quantification of pazopanib

GC40080 Bosutinib-d8

SKI-606 D8

An internal standard for the quantification of bosutinib

GC40054 CCT241161 A multi-kinase inhibitor

GC34414 AZ7550 Mesylate (AZ7550 trimesylate salt) An active metabolite of AZ 9291

GC34287 AZ7550 hydrochloride An active metabolite of AZ 9291

GC34217 Cetuximab (C225)

西妥昔单抗; C225

西妥昔单抗是一种嵌合单克隆抗体，由鼠类抗 EGFR 单克隆抗体 M225 的可变区和人 IgG1 恒定区融合而成。

GC34216 Bevacizumab (Anti-Human VEGF, Humanized Antibody)

贝伐珠单抗 (PBS); Anti-Human VEGF, Humanized Antibody (PBS)

贝伐单抗Bevacizumab是一种抗VEGF的人源化单克隆抗体,通过与VEGF特异性结合,阻断其与细胞表面相应的受体结合,进而抑制血管生成。

GC34215 Trastuzumab (Anti-Human HER2, Humanized Antibody)

曲妥珠单抗; Anti-Human HER2, Humanized Antibody

曲妥珠单抗是一种针对 HER2 的完全人源化单克隆抗体，它结合受体的外部结构域，并通过抗体依赖性细胞毒性、减少细胞外结构域脱落、抑制二聚化和可能的受体下调来发挥作用。

GC34210 Pertuzumab (Anti-Human HER2, Humanized Antibody)

帕妥珠单抗（抗人 HER2，人源化抗体）是指定为 HER 二聚化抑制剂的新型药物中的第一个，是一种人源化 IgG1 单克隆抗体 (mAb)，可空间结合 erbB2 受体的结构域 II。

GC34159 Ilorasertib (ABT-348)

ABT-348

A multi-kinase inhibitor

GC34131 Protein kinase inhibitors 1 Proteinkinaseinhibitors1是一个新型的HIPK2抑制剂，其IC50值为74nM,Kd值为9.5nM。

GC34126 NVP-ACC789 (ACC-789)

N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺,ACC-789; ZK202650

An inhibitor of VEGFRs

GC34119 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride)

1-叔丁基-3-(1-萘基)-1H-吡唑并[3,4-D]嘧啶-4-胺盐酸盐,1-NA-PP 1 hydrochloride

1-Naphthyl PP1 hydrochloride 是 src 家族激酶 v-Src 的选择性抑制剂

GC34110 WEHI-345 analog WEHI-345(analog)是一种Src抑制剂。

GC34109 Tirbanibulin Mesylate (KX2-391 (Mesylate))

KX2-391 Mesylate; KX01 Mesylate

A Src kinase inhibitor

GC34105 PD153035 Hydrochloride (ZM 252868)

SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride

A highly potent EGFR inhibitor

GC34077 Vecabrutinib (SNS-062)

维卡布鲁替尼,SNS-062

Vecabrutinib (SNS-062) (SNS-062) 是一种有效的非共价 BTK 和 ITK 抑制剂，Kd 值分别为 0.3 nM 和 2.2 nM。 Vecabrutinib (SNS-062) 对 ITK 的 IC50 为 24 nM。

GC34067 Rogaratinib (BAY1163877)

罗加替尼,BAY1163877

Rogaratinib (BAY1163877) (BAY1163877) 是一种有效的选择性成纤维细胞生长因子受体 (FGFR) 抑制剂。

GC34026 Tyrosine kinase-IN-1 Tyrosinekinase-IN-1是多靶点的酪氨酸激酶抑制剂，抑制KDR，Flt-1，FGFR1和PDGFRα的IC50值分别为4，20，4，2nM。

GC33882 GNE-6468 GNE-6468是一个有效且有选择性的RORγ(RORc)拮抗剂，对HEK-293细胞的EC50值为13nM。

GC33874 R112 A Syk inhibitor

GC33840 SU1498 (AG 1498)

AG 1498; Tyrphostin SU 1498

A selective inhibitor of VEGFR2/FLK1

GC33519 2,5-Dihydroxybenzoic acid

2,5-二羟基苯甲酸

A benzoic acid with diverse biological activities

GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2是BCR-ABL1激酶的抑制剂，其对ABL1native和ABL1T315I的IC50值分别为57nM，773nM。

GC33362 Amuvatinib hydrochloride (MP470 hydrochloride)

MP470 hydrochloride; HPK 56 hydrochloride

A multi-targeted RTK inhibitor

GC33361 DDR Inhibitor DDRInhibitor是一种高效的盘状结构域受体(discoidindomainreceptor)抑制剂，对DDR2的IC50值为3.3nM，在浓度为1.5nM时，对DDR1有53%的抑制作用。

GC33352 CP-547632

3-[(4-溴-2,6-二氟苄基)氧基]-5-[3-[4-(吡咯烷-1-基)丁基]脲基]异噻唑-4-甲酰胺

A potent inhibitor of VEGFR2 and bFGF

GC33351 CZC-8004 (CZC-00008004)

N2-(4-(氨甲基)苯)-5-氟-N4-苯基嘧啶-2,4-二胺,CZC-00008004

A tyrosine kinase inhibitor

GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1是一种BCR-ABL酪氨酸激酶抑制剂，pIC50值为6.46，可能用于慢性髓细胞白血病的研究。

GC33319 2-Keto Crizotinib (PF-06260182)

克里唑替尼杂质,PF-06260182

2-Keto Crizotinib (PF-06260182) (PF-06260182) 是 crizotinib 的活性内酰胺代谢物。

GC33297 DDR1-IN-3 DDR1-IN-3 是一种选择性 Discoidin Domain Receptor 1 (DDR1) 抑制剂，IC50 值为 9.4 nM。 DDR1-IN-3 也抑制 TRK 家族。

GC33273 TAS-115 mesylate (TAS-115 methanesulfonate)

TAS-115 mesylate

A multi-kinase inhibitor

GC33271 R916562 R916562是有效的和有选择性的Axl/VEGF-R2双重抑制剂,IC50值分别为136和24nM。

GC33266 JNJ-38877618 JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).

GC33246 AZD3229 Tosylate An inhibitor of c-Kit-driven cell proliferation

GC33242 FLT3-IN-1 Succinate FLT3-IN-1Succinate是有效地FLT3抑制剂，来自专利WO2015056683A1，化合物实例A。

GC33241 CSF1R-IN-1 CSF1R-IN-1 is a CSF1R (Colony Stimulating Factor 1 Receptor) inhibitor with an IC50 of 0.5 nM in vitro kinase activity assay.

GC33203 c-Met-IN-2 c-Met-IN-2是一种有效的，选择性的，可口服的c-Met抑制剂，IC50值为0.6nM，具有抗肿瘤活性。

GC33201 GZD856 GZD856是一种新型，有口服活性的PDGFRα/β抑制剂，IC50分别为68.6和136.6nM。具有抗肺癌活性。也是Bcr-AblT315I的抑制剂，对Bcr-Abl和T315I突变型的IC50分别为19.9和15.4 nM。

GC33195 EGFR-IN-2 EGFR-IN-2是一种非共价的，不可逆的，突变选择性的二代EGFR抑制剂。

GC33190 Ensartinib (X-396)

X-396

An ALK inhibitor

GC33189 SAR125844 SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).

GC33181 T338C Src-IN-2

T338CSrc-IN-2是突变型c-Src激酶抑制剂，IC50值317nM，还能抑制T338C/V323A和T338C/V323S双突变Src活性，IC50值57和19nM。