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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information
GC15282 LOXO-101 (Larotrectinib) sulfate
(3S)-N-[5-[(2R)-2-(2,5-二氟苯基)-1-吡咯烷基]吡唑并[1,5-A]嘧啶-3-基]-3-羟基-1-吡咯烷甲酰胺硫酸盐,LOXO-101 sulfate; ARRY-470 sulfate
A pan-Trk inhibitor
GC11321 PRT-060318
PRT318
A potent and selective Syk inhibitor
GC15466 RO9021 RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂，平均 IC50 为 5.6 nM。
GC12038 RG 13022
Tyrphostin RG13022
An inhibitor of EGF receptor kinase
GC14582 SU5614
(3Z)-5-氯-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-1,3-二氢-2H-吲哚-2-酮
A multi-kinase inhibitor
GC12281 EAI045 A potent inhibitor of mutant EGFRs
GC10607 GNF-7 A multi-kinase inhibitor
GC17294 CHMFL-ABL-053 CHMFL-ABL-053 (Compound 18a) 是一种有效的、选择性的、可口服的 BCR-ABL、SRC 和 p38 激酶抑制剂，对 ABL1、SRC 和 p38 的 IC50 值分别为 70、90 和 62 nM。
GC14488 NPS-1034
2-(4-氟苯基)-N-[3-氟-4-[(3-苯基-1H-吡咯并[2,3-B]吡啶-4-基)氧基]苯基]-2,3-二氢-1,5-二甲基-3-氧代-1H-吡唑-4-甲酰胺
A dual MET/AXL inhibitor
GC13143 AZD3759
AZD3759
A brain penetrant inhibitor of EGFR
GC10165 Dovitinib (TKI258) Lactate
多韦替尼,TKI258 lactate hydrate; CHIR-258 lactate hydrate
A multi-kinase inhibitor
GC14218 TP-0903
TP-0903
An Axl kinase inhibitor
GC17790 CL-387785 (EKI-785)
EKI-785; WAY-EKI 785
An irreversible inhibitor of EGFR kinase activity
GC16321 EGF816
那扎替尼; EGF816
An inhibitor of mutant EGFR
GC10355 Fruquintinib(HMPL-013)
呋喹替尼; HMPL-013
An inhibitor of VEGF1, -2, and -3
GC17772 BMS-817378
[3-[[4-((2-氨基-3-氯吡啶-4-基)氧基)-3-氟苯基]氨基甲酰基]-5-(4-氟苯基)-4-氧代-4H-吡啶-1-基]甲基磷酸二氢酯
Potent ATP competitive inhibitor of Met/VEGFR2
GC14476 Entrectinib
恩曲替尼; NMS-E628; RXDX-101
A pan-Trk, ROS1, and ALK inhibitor
GC12222 Pexidartinib (PLX3397)
培西达替尼,PLX-3397
Pexidartinib(PLX3397) 是一种口服小分子酪氨酸激酶抑制剂，对集落刺激因子 1(CSF1) 受体 (IC50=20nM)、KIT 原癌基因受体酪氨酸激酶 (KIT)(IC50 = 10nM) 和类 FMS 酪氨酸激酶 3Pexidartinib 在体外是一种比伊马替尼更强的 KIT 抑制剂。
GC11140 Radotinib(IY-5511)
拉多替尼
A selective Bcr-Abl tyrosine kinase inhibitor
GC17637 CTX0294885 A broad spectrum kinase inhibitor used in proteomics
GC17669 AMG-47A
4-甲基-3-[2-[[2-(4-吗啉基)乙基]氨基]-6-喹唑啉基]-N-[3-(三氟甲基)苯基]苯甲酰胺
A multi-kinase inhibitor
GC17500 SU6656 Inhibitor of Src kinases
GC12955 AZ5104
奥西替尼中间体
An active metabolite of AZD 9291
GC17959 AZD2932 A multi-kinase inhibitor
GC16604 Altiratinib
DCC-2701
A multiple kinase inhibitor
GC17916 Poziotinib
波齐替尼
An inhibitor of EGFRs
GC15075 PLX647 A dual inhibitor of FMS and KIT
GC10759 CH5183284 (Debio-1347)
Debio 1347; CH5183284
An inhibitor of FGFR1, 2, and 3
GC10833 BLU9931 A selective FGFR4 inhibitor
GC13850 PF-06447475 PF-06447475 是一种高效、选择性和脑渗透性 LRRK2 抑制剂，IC50 为 3 nM。
GC15801 ACTB-1003
ACTB-1003
A multi-kinase inhibitor
GC12539 BLZ945
BLZ945
A selective inhibitor of CSF1R
GC14241 LDC1267 A TAM family kinase inhibitor
GC17323 FIIN-2 An FGFR inhibitor
GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor
GC16813 Defactinib
地法替尼,VS-6063; PF-04554878
A FAK inhibitor
GC14794 PF-06463922
劳拉替尼; PF-06463922
An orally available inhibitor of ALK and ROS1
GC11209 Cerdulatinib (PRT062070)
赛度替尼,PRT062070; PRT2070
A dual inhibitor of Syk and JAKs
GC15556 UNC2025
反式-4-[2-(丁基氨基)-5-[4-[(4-甲基-1-哌嗪基)甲基]苯基]-7H-吡咯并[2,3-D]嘧啶-7-基]-环己醇
An orally bioavailable inhibitor of Mer and Flt3
GC13600 WH-4-023
Dual LCK/SRC inhibitor
An inhibitor of Lck and Src
GC13213 WZ3146 An inhibitor of mutant EGFR
GC12178 G-749
G-749
An FLT3 kinase inhibitor
GC13868 GNE-9605 A potent LRRK2 inhibitor
GC16430 GS-9973
GS-9973
A selective spleen tyrosine kinase inhibitor
GC17622 Ro 08-2750 A p75^NTR ligand
GC14284 SR 2211 Selective inverse agonist of RORγ
GC15009 SR 1001 An RORα and γ inverse agonist
GC11486 ANA 12 A TrkB receptor antagonist
GC17630 PF 06465469 PF 06465469 是 ITK 的共价抑制剂，IC50 为 2 nM。
GC17638 KB SRC 4 KB SRC 4 是一种有效的、高选择性的 c-Src 抑制剂，Ki 为 44 nM，Kd 为 86 nM，对 c-Abl 没有抑制作用，最高可达 125 μM; KB SRC 4 具有抗肿瘤活性。