Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information

GC15000 Herbimycin A

除莠霉素A

An inhibitor of tyrosine kinases and Hsp90

GC11417 SU 4312

NSC 86429

A selective dual inhibitor of VEGFR2 and PDGFR

GC16021 Lavendustin A

薰草菌素; RG-14355

A selective inhibitor of EGF receptor-associated tyrosine kinase

GC14779 RR-src A synthetic peptide substrate

GC10523 KX1-004 An inhibitor of Src-PTK

GC16183 EG00229 An NRP-1 antagonist

GC16038 CZC-25146 A potent LRRK2 inhibitor

GC15196 GNE0877 A selective LRRK2 inhibitor

GC13500 UNC2881 A Mer kinase inhibitor

GC15936 MSDC-0160

Mitoglitazone; CAY10415

A thiazolidinedione

GC17582 ML347

LDN 193719

A selective ALK1 and ALK2 inhibitor

GC17035 LDN-212854

5-（6-（4-（哌嗪-1-基）苯基）吡唑并[1,5-a]嘧啶-3-基）喹啉

An ALK2 inhibitor

GC14298 DMH-1

BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482

A potent ALK2 inhibitor

GC12616 Crizotinib hydrochloride

克里唑替尼盐酸,PF-02341066 hydrochloride

Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。

GC12121 GNE-7915 A selective LRRK2 inhibitor

GC17365 DDR1-IN-1

N-[3-[(2,3-二氢-2-氧代-1H-吲哚-5-基)氧基]-4-甲基苯基]-4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯甲酰胺

A selective discoidin domain receptor 1 inhibitor

GC15271 Tyrphostin AG 879

AG 879

A non-specific tyrphostin ErbB2 inhibitor

GC11107 PF-573228

6-[(4-((3-(甲磺酰基)苄基)氨基)-5-三氟甲基嘧啶-2-基)氨基]-3,4-二氢-1H-喹啉-2-酮

A selective focal adhesion kinase inhibitor

GC10250 Mubritinib (TAK 165)

木利替尼; TAK-165

A selective inhibitor of HER2

GC13833 BMS-794833 An inhibitor of c-Met and VEGFR2

GC17654 AZ191

DYRK1B抑制剂(AZ191)

A selective DYRK1B inhibitor

GC13854 AG-490 (Tyrphostin B42)

酪氨酸磷酸化抑制剂AG490

AG-490 (Tyrphostin B42)是EGFR抑制剂,IC50为0.1 µM, AG-490对JAK2也有抑制作用。

GC14123 GW441756 A potent inhibitor of TrkA

GC15647 ID-8

1-(4-甲氧基苯基)-2-甲基-3-硝基-1H-吲哚-6-醇

A cell culture supplement for maintaining embryonic stem cell pluriotency

GC17793 UNC2250

反式-4-[[2-(丁基氨基)-5-[5-(4-吗啉基甲基)-2-吡啶基]-4-嘧啶基]氨基]环己醇

A selective Mer kinase inhibitor

GC16698 AZD-9291 mesylate

奥希替尼甲磺酸盐; AZD-9291 mesylate; Mereletinib mesylate

An inhibitor of mutant EGFR

GC16308 AZD-9291

奥希替尼; AZD-9291; Mereletinib

An inhibitor of mutant EGFR

GC17789 A 419259 trihydrochloride

7-[反式-4-(4-甲基-1-哌嗪基)环己基]-5-(4-苯氧基苯基)-7H-吡咯并[2,3-D]嘧啶-4-胺三盐酸盐,RK 20449 trihydrochloride

An inhibitor of Src family kinases

GC10758 Tyrphostin 9

酪氨酸磷酸化抑制剂A9,Tyrphostin 9; Malonoben

An inhibitor of EGF receptor kinase

GC11555 ZM 323881 HCl

5-[(7-苄氧基喹唑啉-4-基)氨基]-4-氟-2-甲基苯酚盐酸盐

A potent and selective VEGFR2 inhibitor

GC10314 Imatinib (STI571)

伊马替尼; STI571; CGP-57148B

伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。