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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase(酪氨酸激酶)

  1. Cat.No. 产品名称 Information
  2. GC17618 R428

    R-428;R 428;BGB324

     R428作为一种Axl抑制剂,在纳摩尔浓度下阻断Axl在其C端对接位点Tyr821上的自动磷酸化。
  3. GC14552 LDK378

    色瑞替尼; LDK378

     An ALK inhibitor
  4. GC14256 Tivantinib (ARQ 197)

    (3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮,ARQ-197;ARQ197

     An inhibitor of c-Met
  5. GC16580 LDN-193189

    LDN 193189;LDN193189

    An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
  6. GC10970 WP1130

    WP 1130; WP-1130

     A deubiquitinase inhibitor
  7. GC10362 Neratinib (HKI-272)

    来那替尼; HKI-272

     A dual inhibitor of EGFR and HER2
  8. GC14767 PF-00562271

    PF-562271;PF00562271;PF62271

     A selective FAK/PYK2 inhibitor
  9. GC10225 Dacomitinib (PF299804, PF299)

    达克替尼; PF-00299804; PF-299804

     A pan-ErbB receptor tyrosine kinase inhibitor
  10. GC15818 RAF265

    CHIR-265;RAF 265;RAF-265;CHIR265

     A B-Raf and VEGFR2 inhibitor
  11. GC15380 PF-562271

    N-甲基-N-[3-[[[2-[(2-氧代-2,3-二氢-1H-吲哚-5-基)氨基]-5-三氟甲基嘧啶-4-基]氨基]甲基]吡啶-2-基]甲磺酰胺,PF562271;PF 562271

     A selective FAK/PYK2 inhibitor
  12. GC14906 Crenolanib (CP-868596)

    [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596

     An inhibitor of PDGFRα/β and FLT3
  13. GC16343 GNF-5837 A pan-Trk inhibitor
  14. GC17283 AP26113

    Brigatinib analog

     A potent ALK inhibitor
  15. GC10944 Butein

    紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone

     A plant polyphenol
  16. GC13045 Tyrphostin AG 1296

    AG1296

     An inhibitor of PDGF receptor kinase
  17. GC12058 TCS 359

    Fms-like Tyrosine Kinase Inhibitor, TCS 359

     A cell-permeable FLT3 inhibitor
  18. GC16991 PQ 401 An inhibitor of IGF-1R
  19. GC17286 GW2580 An inhibitor of cFMS kinase
  20. GC17647 AG-18

    酪氨酸磷酸化抑制剂23,Tyrphostin A23; RG-50810; AG 18

     An inhibitor of EGF receptor kinase
  21. GC11015 PD168393 An irreversible EGFR kinase inhibitor
  22. GC14898 Tie2 kinase inhibitor

    Tunica Interna Endothelial Cell Kinase 2 Inhibitor

     Tie2 kinase inhibitor是一种可逆的选择性Tie2抑制剂，IC50为250 nM。
  23. GC15658 R406(free base) A potent and selective Syk inhibitor
  24. GC17615 Quizartinib (AC220)

    奎扎替尼; AC220

     An inhibitor of FLT3
  25. GC12590 KRN 633

    N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲

     A VEGF receptor tyrosine kinase inhibitor
  26. GC14214 BMS-777607

    N-[4-[(2-氨基-3-氯吡啶-4-基)氧基]-3-氟苯基]-4-乙氧基-1-(4-氟苯基)-2-氧代-1,2-二氢吡啶-3-甲酰胺,BMS 817378

     BMS-777607 是一种泛 TAM 抑制剂，对不同类型的癌症显示出抗肿瘤活性。
  27. GC11892 AEE788 (NVP-AEE788)

    6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-D]嘧啶-4-胺,NVP-AEE 788

     An inhibitor of EGFR and VEGFR tyrosine kinases
  28. GC14349 SB525334

    6-[2-(1,1-二甲基乙基)-5-(6-甲基-2-吡啶基)-1H-咪唑-4-基]喹喔啉

     A potent inhibitor of TGF-β R1/ALK5 kinase
  29. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  30. GC16732 TSU-68 (SU6668,Orantinib)

    SU6668; TSU-68

     An inhibitor of select receptor tyrosine kinases
  31. GC17955 Vatalanib (PTK787) 2HCl

    瓦他拉尼,PTK787 dihydrochloride; CGP-797870 dihydrochloride; ZK-222584 dihydrochloride

     A potent and selective VEGF receptor inhibitor
  32. GC15197 Saracatinib (AZD0530)

    塞卡替尼; AZD0530

     A dual inhibitor of c-Src and Abl
  33. GC12910 Canertinib (CI-1033)

    卡奈替尼; CI-1033; PD-183805

     Canertinib (CI-1033) (CI-1033;PD-183805) 是一种有效且不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自磷酸化，IC50 为 7.4 和 9 nM。
  34. GC14238 Brivanib Alaninate (BMS-582664)

    1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氧基]-2-丙醇L-丙氨酸酯,BMS-582664

     A prodrug form of brivanib
  35. GC12963 NVP-AEW541

    AEW541

     An IGF-1R inhibitor
  36. GC17612 GSK1904529A

    N-(2,6-二氟苯基)-5-[3-[2-[[5-乙基-2-甲氧基-4-[4-[4-(甲基磺酰基)-1-哌嗪基]-1-哌啶基]苯基]氨基]-4-嘧啶基]咪唑并[1,2-A]吡啶-2-基]-2-甲氧基苯甲酰胺, GSK4529

     A dual inhibitor of InsR and IGF-1R kinases
  37. GC15735 Foretinib (GSK1363089)

    N-[3-氟-4-[[6-甲氧基-7-[[3-(吗啉-4-基)丙基]氧]喹啉-4-基]氧]苯基]-N'-(4-氟苯基)环丙烷-1,1-二甲酰胺,XL880; GSK1363089; GSK089; EXEL-2880

     A broad-spectrum tyrosine kinase inhibitor
  38. GC13257 AC480 (BMS-599626)

    AC480

     A dual inhibitor of EGFR and HER2
  39. GC11336 Motesanib Diphosphate (AMG-706)

    二磷酸莫替沙尼,AMG 706 Diphosphate

     A multikinase inhibitor
  40. GC13598 MGCD-265

    N-(3-氟-4-(2-(1-甲基-1H-咪唑-4-基)噻吩并[3,2-B]吡啶-7-氧基)苯基氨基硫代甲酰基)-2-苯乙酰胺

     A c-Met and VEGFR2 inhibitor
  41. GC11250 WZ8040 An inhibitor of mutant EGFR
  42. GC12600 AMG-208 A potent c-Met inhibitor
  43. GC15454 Lenvatinib (E7080)

    仑伐替尼; E7080

     E7080，称为乐伐替尼，是一种口服多靶点酪氨酸激酶抑制剂，包括 VEGF、FGF 和 SCF 受体，已被证明可以提高放射性碘难治性甲状腺癌患者的生存率。
  44. GC17473 Pelitinib (EKB-569)

    培利替尼; EKB-569; WAY-EKB 569

     An EGFR receptor tyrosine kinase inhibitor
  45. GC14957 OSI-930

    噻尔非尼

     A dual inhibitor of Kit and VEGFR2
  46. GC11692 Brivanib (BMS-540215)

    布立尼布; BMS-540215

     A VEGFR1, VEGFR2, and FGFR1 inhibitor
  47. GC12036 Tivozanib (AV-951)

    替沃扎尼; AV-951; KRN951

     Tivozanib (AV-951; KRN951) 是一种有效的、选择性的、具有口服活性的 VEGFR 酪氨酸激酶抑制剂，对 VEGFR-1、VEGFR-2、VEGFR-3 的 IC50 分别为 0.21、0.16、0.24 nM。 Tivozanib 抑制肿瘤组织中的血管生成和血管通透性，并显示出抗肿瘤活性。 Tivozanib 具有研究转移性肾细胞癌（RCC）的潜力。
  48. GC13091 CP-724714

    2-甲氧基-N-[(2E)-3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺

     A selective HER2/ErbB2 tyrosine kinase inhibitor
  49. GC12585 JNJ-38877605

    6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-噻唑并[4,3-B]吡嗪-3-基]甲基]-喹啉

     An inhibitor of Met kinase
  50. GC15779 Cabozantinib (XL184, BMS-907351)

    卡博替尼; XL184; BMS-907351

     Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。
  51. GC16421 Cediranib (AZD217)

    西地尼布; AZD2171

     An inhibitor of VEGF receptor tyrosine kinases

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