Tyrosine Kinase(酪氨酸激酶)

Cat.No. 产品名称 Information

GC48840 9-Methoxyellipticine

Methoxy-9-ellipticine, NSC 69187

An alkaloid with anticancer activity

GC48800 SU 4942 A modulator of tyrosine kinase signaling

GC48614 IMP-1710 A clickable UCH-L1 inhibitor

GC48387 Inostamycin A A bacterial metabolite with anticancer activity

GC48332 RR-Src (trifluoroacetate salt)

Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, RRLIEDAEYAARG, Src-Peptide

A synthetic peptide substrate

GC50706 JBJ-03-142-02 Highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor

GC50660 HIOC HIOC 是 TrkB（原肌球蛋白相关激酶 B）受体的有效和选择性激活剂。

GC48118 Sunitinib-d10

舒尼替尼-D10,SU 11248-d10

An internal standard for the quantification of sunitinib

GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7

GC48022 Radotinib-d6

IY-5511

Radotinib-d6 是氘标记的 Radotinib。

GC47938 Pericosine A

(+)-Pericosine A

A fungal metabolite with anticancer activity

GC47771 NG 25 (hydrochloride hydrate) An inhibitor of MAP4K2 and TAK1

GC47697 Mobocertinib

莫博替尼; TAK-788; AP32788

An inhibitor of mutant EGFR and HER2 receptors

GC47687 ML-209 An RORγt antagonist

GC47570 Lipoxygenin An inhibitor of 5-LO

GC47452 Imatinib-d3

STI571-d3 hydrochloride; CGP-57148B-d3 hydrochloride

An internal standard for the quantification of imatinib

GC47398 Genistein-d4

金雀异黄酮-D4,NPI 031L-d4

An internal standard for the quantification of genistein

GC47395 Gefitinib-d6

D6-吉非替尼,ZD1839-d6

An internal standard for the quantification of gefitinib

GC47393 Ganglioside GM1 Mixture (porcine brain) (ammonium salt)

GM1, Monosialoganglioside GM1

A sphingolipid

GC47392 Ganglioside GM1 Mixture (ovine) (ammonium salt)

GM1, Monosialoganglioside GM1

A sphingolipid

GC47350 Finasteride-d9

非那雄胺-D9,MK-906-d9

An internal standard for the quantification of finasteride

GC47321 Etifoxine-13C-d3

艾替伏辛 13C-d3

A neuropeptide with diverse biological activities

GC47303 Erlotinib-d6 (hydrochloride)

埃罗替尼-D6盐酸盐,CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride

An internal standard for the quantification of erlotinib

GC47182 Dehydrolithocholic Acid

3-Ketolithocholic Acid

A major metabolite of lithocholic acid

GC46924 BIBF 1120-13C-d3

Nintedanib-13C-d3

A neuropeptide with diverse biological activities

GC46899 Axitinib-13C-d3

阿昔替尼杂质,AG-013736 13CD3

An internal standard for the quantification of axitinib

GC46809 Afatinib-d6

BIBW 2992 D6

An internal standard for the quantification of afatinib

GC46628 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉

A building block and synthetic intermediate

GC46490 1-Palmitoyl-d3-2-hydroxy-sn-glycero-3-PC

1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine-d3, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine-d3, LPC-d3, 16:0/0:0(d3) Lyso-PC, 1-Palmitoyl-sn-glycero-3-Phosphocholine-d3, PC(16:0/0:0)-d3, 16:0/0:0-PC-d3

A neuropeptide with diverse biological activities

GC46474 18-Deoxyherboxidiene

RQN-18690A

A bacterial metabolite with antiangiogenic activity

GC46304 (±)-Nebivolol-d4 (hydrochloride) A neuropeptide with diverse biological activities

GC61217 Protein kinase inhibitors 1 hydrochloride Proteinkinaseinhibitors1hydrochloride是一种有效的HIPK2抑制剂，对HIPK1和HIPK2的IC50值分别为136和74nM，对HIPK2的Kd值为9.5nM。

GC61161 Osimertinib D6

AZD-9291-d6; Mereletinib-d6

OsimertinibD6(AZD-9291D6)是Osimertinib的一种氘代化合物。Osimertinib是一种不可逆和突变的选择性的EGFR抑制剂，抑制EGFRL858R和EGFRL858R/T790M的IC50分别为12和1nM。

GC61111 NBI-31772 hydrate A nonpeptide ligand that releases IGF-1 from IGFBP

GC60930 Imatinib D4

[2H4]-伊马替尼,STI571 D4; CGP-57148B D4

ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。

GC60868 Gefitinib D8

吉非替尼杂质-D8,ZD1839-d8

GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。

GC60805 EMI48 EMI48是EMI1的衍生物，EMI48比EMI1对突变型EGFR具有更大的效力。EMI48抑制EGFR三重突变体。

GC60726 CP-547632 TFA A potent inhibitor of VEGFR2 and bFGF

GC60629 BDTX-189

BDTX-189

An inhibitor of wild-type and mutant EGFR and HER2

GC60601 ARRY-382 ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.

GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.

GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.

GC60372 TrkA-IN-1 TrkA-IN-1 是一种有效的选择性肌球蛋白相关激酶 A (TrkA) 抑制剂，在基于细胞的测定中，IC50 为 99 nM。TrkA-IN-1 具有镇痛作用。

GC60365 TIE-2/VEGFR-2 kinase-IN-1 TIE-2/VEGFR-2 kinase-IN-1 用于合成 TIE-2 或者 VEGFR-2 抑制剂，从专利 WO2003022852 中获得，例 14。TIE-2/VEGFR-2 kinase-IN-1 用于研究不适当的血管生成相关疾病。

GC60283 Pentagamavunon-1

PGV-1

Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。

GC60270 Nilotinib D6

尼罗替尼-D6,AMN107-d6

An internal standard for the quantification of nilotinib

GC60175 GIP (1-30) amide,Human acetate GIP (1-30) amide,Human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 片段。葡萄糖依赖性促胰岛素多肽是一种肠降血糖素激素，可刺激胰岛素分泌并减少餐后血糖波动。GIP (1-30) amide (Human) 在 10-9-10-6 M 范围内剂量依赖性地促进胰岛素分泌。

GC60154 Erlotinib D6

CP-358774-d6; NSC 718781-d6; OSI-774-d6

An internal standard for the quantification of erlotinib

GC39689 3-Hydroxy Midostaurin

CGP52421

3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代谢产物，可有效抑制 FMS 样酪氨酸激酶 3 (FLT3) 自磷酸化，在培养基和血浆中的 IC50 分别为 132 nM 和 9.8 μM。与 PKC412 相比，3-Hydroxy Midostaurin 的选择性较低，但细胞毒性更高。

GC39623 DCC-3014

DCC-3014

Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.