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Home >> Signaling Pathways >> Tyrosine Kinase >> Discoidin Domain Receptor

Discoidin Domain Receptor(盘状结构域受体)

Discoidin domain receptors (DDRs) are receptor tyrosine kinases with the unique ability among receptor tyrosine kinases to respond to collagen. Several signaling molecules have been implicated in DDR signaling, including Shp-2, Src, and MAPK pathways. DDRs have been reported to induce the expression of various genes including matrix metalloproteinases and bone morphogenetic proteins, but the regulatory mechanisms underlying DDR-induced gene expression remain to be determined. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets.

Products for  Discoidin Domain Receptor

  1. Cat.No. 产品名称 Information
  2. GC73659 DDR1/2 inhibitor-2 DDR1/2 inhibitor-2（实施例31）是一种DDR1/DDR2抑制剂，IC50值小于100nM。
  3. GC70345 DDR2-IN-1 DDR2-IN-1是有效的DDR2抑制剂，IC50为26nM。
  4. GC66476 DDR1-IN-6 DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。
  5. GC65378 DDR1-IN-5 DDR1-IN-5 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 7.36 nM。DDR1-IN-5 抑制 DDR1b (Y513) 自磷酸化，IC50 为 4.1 nM。DDR1-IN-5 具有抗癌活性。
  6. GC65212 FGFR1/DDR2 inhibitor 1 FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2).
  7. GC64268 DDR1-IN-4 DDR1-IN-4 (Compound 2.45) 是有效、选择性的盘肽结构域受体 1 (DDR1) 自磷酸化的抑制剂，其对 DDR1 和 DDR2 的IC50 值分别为 29 nM 和 1.9 μM。
  8. GC39301 VU6015929 VU6015929 is a selective Discoidin Domain Receptor 1/2 (DDR1/2) inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively. VU6015929 potently inhibits collagen-IV production.
  9. GC38206 WRG-28 WRG-28 是选择性，细胞外作用的 DDR2 变构抑制剂，IC50 为 230 nM。WRG-28 通过受体的变构调节特异地抑制受体-配体相互作用。WRG-28 通过靶向 DDR2 抑制肿瘤侵袭和迁移，基质的肿瘤支持作用，并抑制肺中的转移性乳腺肿瘤细胞定植。
  10. GC36585 Merestinib dihydrochloride

    N-[3-氟-4-[[1-甲基-6-(1H-吡唑-4-基)-1H-吲唑-5-基]氧基]苯基]-1-(4-氟苯基)-1,2-二氢-6-甲基-2-氧代-3-吡啶甲酰胺二盐酸盐,LY2801653 dihydrochloride

     Merestinib dihydrochloride (LY2801653 dihydrochloride) 是一种II型ATP竞争性的 MET 抑制剂，Ki 值为 2 nM。
  11. GC35822 DDR1-IN-1 dihydrochloride DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2.
  12. GC33361 DDR Inhibitor DDRInhibitor是一种高效的盘状结构域受体(discoidindomainreceptor)抑制剂，对DDR2的IC50值为3.3nM，在浓度为1.5nM时，对DDR1有53%的抑制作用。
  13. GC33297 DDR1-IN-3 DDR1-IN-3 是一种选择性 Discoidin Domain Receptor 1 (DDR1) 抑制剂，IC50 值为 9.4 nM。 DDR1-IN-3 也抑制 TRK 家族。
  14. GC31724 DDR1-IN-2

    7rh

     DDR1-IN-2 (DDR1-IN-2) 是一种盘状结构域受体 1 (DDR1) 的有效抑制剂，IC50 为 13.1 nM，对 DDR2 的抑制效果也较弱，IC50 为 203 nM。
  15. GC19332 Sitravatinib

    MGCD516; MG-516

     A multi-kinase inhibitor
  16. GC17365 DDR1-IN-1

    N-[3-[(2,3-二氢-2-氧代-1H-吲哚-5-基)氧基]-4-甲基苯基]-4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯甲酰胺

     A selective discoidin domain receptor 1 inhibitor
  17. GC11057 LY2801653

    梅沙替尼,LY-2801653;LY 2801653

     A MET kinase inhibitor

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